The inability of a dengue NS1 ELISA to detect Zika infections

Detalhes bibliográficos
Autor(a) principal: Lima, Monique da Rocha Queiroz
Data de Publicação: 2019
Outros Autores: Carneiro, Thais Chouin, Azeredo, Elzinandes, Barbosa, Luciana Santos, Souza, Thiara Manuele Alves, Silva, Jéssica Badolato Corrêa da, Nunes, Priscila Conrado Guerra, Dal Fabbro, Márcia, Facco, Izilyanne H. Romanholi, Cunha, Rivaldo Venâncio da, Santos, Flavia Barreto dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42508
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
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spelling Lima, Monique da Rocha QueirozCarneiro, Thais ChouinAzeredo, ElzinandesBarbosa, Luciana SantosSouza, Thiara Manuele AlvesSilva, Jéssica Badolato Corrêa daNunes, Priscila Conrado GuerraDal Fabbro, MárciaFacco, Izilyanne H. RomanholiCunha, Rivaldo Venâncio daSantos, Flavia Barreto dos2020-08-03T15:23:38Z2020-08-03T15:23:38Z2019LIMA, Monique da Rocha Queiroz et al. The inability of a dengue NS1 ELISA to detect Zika infections. Scientifc Reports, v. 9, p. 1-7, 2019.2045-2322https://www.arca.fiocruz.br/handle/icict/4250810.1038/s41598-019-55160-4engNature ResearchIncapacidadeELISA NS1DengueInfecçõesZikaDengue NS1 ELISADetectionInabilityZika infectionsThe inability of a dengue NS1 ELISA to detect Zika infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal de Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.The presence of dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) in Brazil, may result in a difficult diagnosis due to the signs and symptoms shared by those. Moreover, as DENV and ZIKV belong to the same family, serological assays may show a high rate of cross-reactivity. Here, we evaluated a Dengue NS1 capture assay for early and differential diagnosis of dengue during the Zika epidemic occurred in Brazil in 2016. Samples (n = 227) from 218 patients included sera, plasma and urine from previously confirmed acute cases of Zika, dengue and Zika/dengue co-infections. Nine of those patients presented two specimens. The Dengue NS1 test was very specific for dengue diagnosis (99.32%), even in the co-circulation with ZIKV, and exhibited a high accuracy in not detecting acute Zika infections (92.43%). Our findings showed that the dengue NS1 capture test analyzed here was not able to recognize the ZIKV NS1 and its potential for cross-reaction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42508/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdfLucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdfapplication/pdf1147131https://www.arca.fiocruz.br/bitstream/icict/42508/2/LucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdf0c716fcda739573a0c466df635ed2fd9MD52TEXTLucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdf.txtLucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The inability of a dengue NS1 ELISA to detect Zika infections
title The inability of a dengue NS1 ELISA to detect Zika infections
spellingShingle The inability of a dengue NS1 ELISA to detect Zika infections
Lima, Monique da Rocha Queiroz
Incapacidade
ELISA NS1
Dengue
Infecções
Zika
Dengue NS1 ELISA
Detection
Inability
Zika infections
title_short The inability of a dengue NS1 ELISA to detect Zika infections
title_full The inability of a dengue NS1 ELISA to detect Zika infections
title_fullStr The inability of a dengue NS1 ELISA to detect Zika infections
title_full_unstemmed The inability of a dengue NS1 ELISA to detect Zika infections
title_sort The inability of a dengue NS1 ELISA to detect Zika infections
author Lima, Monique da Rocha Queiroz
author_facet Lima, Monique da Rocha Queiroz
Carneiro, Thais Chouin
Azeredo, Elzinandes
Barbosa, Luciana Santos
Souza, Thiara Manuele Alves
Silva, Jéssica Badolato Corrêa da
Nunes, Priscila Conrado Guerra
Dal Fabbro, Márcia
Facco, Izilyanne H. Romanholi
Cunha, Rivaldo Venâncio da
Santos, Flavia Barreto dos
author_role author
author2 Carneiro, Thais Chouin
Azeredo, Elzinandes
Barbosa, Luciana Santos
Souza, Thiara Manuele Alves
Silva, Jéssica Badolato Corrêa da
Nunes, Priscila Conrado Guerra
Dal Fabbro, Márcia
Facco, Izilyanne H. Romanholi
Cunha, Rivaldo Venâncio da
Santos, Flavia Barreto dos
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Monique da Rocha Queiroz
Carneiro, Thais Chouin
Azeredo, Elzinandes
Barbosa, Luciana Santos
Souza, Thiara Manuele Alves
Silva, Jéssica Badolato Corrêa da
Nunes, Priscila Conrado Guerra
Dal Fabbro, Márcia
Facco, Izilyanne H. Romanholi
Cunha, Rivaldo Venâncio da
Santos, Flavia Barreto dos
dc.subject.other.pt_BR.fl_str_mv Incapacidade
ELISA NS1
Dengue
Infecções
Zika
topic Incapacidade
ELISA NS1
Dengue
Infecções
Zika
Dengue NS1 ELISA
Detection
Inability
Zika infections
dc.subject.en.pt_BR.fl_str_mv Dengue NS1 ELISA
Detection
Inability
Zika infections
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-08-03T15:23:38Z
dc.date.available.fl_str_mv 2020-08-03T15:23:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Monique da Rocha Queiroz et al. The inability of a dengue NS1 ELISA to detect Zika infections. Scientifc Reports, v. 9, p. 1-7, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42508
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-019-55160-4
identifier_str_mv LIMA, Monique da Rocha Queiroz et al. The inability of a dengue NS1 ELISA to detect Zika infections. Scientifc Reports, v. 9, p. 1-7, 2019.
2045-2322
10.1038/s41598-019-55160-4
url https://www.arca.fiocruz.br/handle/icict/42508
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/42508/2/LucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/42508/3/LucianaSBarbosa_PriscilaGNunes_etal_IOC_2019.pdf.txt
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