Whole-genome sequence of Schistosoma haematobium

Young, Neil D; Jex, Aaron R; Cantacessi, Cinzia; Hall, Ross S; Hofmann, Andreas; Campbell, Bronwyn E; Gasser, Robin B; Li, Bo; Liu, Shiping; Yang, Linfeng; Xiong, Zijun; Li, Yingrui; Xu, Xun; Chen, Fangyuan; Wu, Xuan; Zhang, Guojie; Fang, Xiaodong; Kang, Yi; Yang, Huanming; Wang, Jun; Wang, Jian; Zerlotini Neto, Adhemar; Oliveira, Guilherme Corrêa de; Loukas, Alex; Ranganathan, Shoba; Rollinson, David; Rinaldi, Gabriel; Brindley, Paul J

Whole-genome sequence of Schistosoma haematobium

Detalhes bibliográficos
Autor(a) principal:	Young, Neil D
Data de Publicação:	2012
Outros Autores:	Jex, Aaron R, Cantacessi, Cinzia, Hall, Ross S, Hofmann, Andreas, Campbell, Bronwyn E, Gasser, Robin B, Li, Bo, Liu, Shiping, Yang, Linfeng, Xiong, Zijun, Li, Yingrui, Xu, Xun, Chen, Fangyuan, Wu, Xuan, Zhang, Guojie, Fang, Xiaodong, Kang, Yi, Yang, Huanming, Wang, Jun, Wang, Jian, Zerlotini Neto, Adhemar, Oliveira, Guilherme Corrêa de, Loukas, Alex, Ranganathan, Shoba, Rollinson, David, Rinaldi, Gabriel, Brindley, Paul J
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/11456
Resumo:	University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.

Metadados do item

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spelling	Young, Neil DJex, Aaron RCantacessi, CinziaHall, Ross SHofmann, AndreasCampbell, Bronwyn EGasser, Robin BLi, BoLiu, ShipingYang, LinfengXiong, ZijunLi, YingruiXu, XunChen, FangyuanWu, XuanZhang, GuojieFang, XiaodongKang, YiYang, HuanmingWang, JunWang, JianZerlotini Neto, AdhemarOliveira, Guilherme Corrêa deHofmann, AndreasLoukas, AlexRanganathan, ShobaRollinson, DavidRinaldi, GabrielBrindley, Paul J2015-08-19T12:40:07Z2015-08-19T12:40:07Z2012YOUNG, Neil D et al. Whole-genome sequence of Schistosoma haematobium. Nature Genetics, vol.44, n. 2, p. 221-225, 2012.1061-4036https://www.arca.fiocruz.br/handle/icict/1145610.1038/ng.1065engNature Publishing GroupWhole-genome sequence of Schistosoma haematobiuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Melbourne. Faculty of Veterinary Science. Victoria, Australia.University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.BGI–Shenzhen. Shenzhen, China.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil.Griffith University. Eskitis Institute for Cell & Molecular Therapies. Brisbane, Queensland, Australia.James Cook University. Tropical Medicine and Rehabilitation Sciences. School of Public Health. Cairns, Queensland, Australia.Macquarie University. Department of Chemistry and Biomolecular Sciences. Sydney, New South Wales, Australia/ National University of Singapore. Department of Biochemistry. Singapore.Natural History Museum. London, UK.Universidad de la República. Departamento de Genética. Montevideo, Uruguay/ George Washington University. Department of Microbiology, Immunology & Tropical Medicine. Washington, DC, USA.George Washington University. Department of Microbiology, Immunology & Tropical Medicine. Washington, DC, USA.Schistosomiasis is a neglected tropical disease caused by blood flukes (genusSchistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobiumhas come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancerand as a predisposing factor for HIV/AIDS.The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventionsSchistosomiasisblood flukesPraziquantelinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11456/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALWhole-genome sequence of...Nature Publishing Group.pdfWhole-genome sequence of...Nature Publishing Group.pdfapplication/pdf6908429https://www.arca.fiocruz.br/bitstream/icict/11456/2/Whole-genome%20sequence%20of...Nature%20Publishing%20Group.pdf1637dbf1a32ec8a4596ec0c880f057fcMD52TEXTWhole-genome sequence of...Nature Publishing Group.pdf.txtWhole-genome sequence of...Nature Publishing Group.pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/11456/3/Whole-genome%20sequence%20of...Nature%20Publishing%20Group.pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD53icict/114562019-06-19 10:05:46.534oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:05:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Whole-genome sequence of Schistosoma haematobium
title	Whole-genome sequence of Schistosoma haematobium
spellingShingle	Whole-genome sequence of Schistosoma haematobium Young, Neil D Schistosomiasis blood flukes Praziquantel
title_short	Whole-genome sequence of Schistosoma haematobium
title_full	Whole-genome sequence of Schistosoma haematobium
title_fullStr	Whole-genome sequence of Schistosoma haematobium
title_full_unstemmed	Whole-genome sequence of Schistosoma haematobium
title_sort	Whole-genome sequence of Schistosoma haematobium
author	Young, Neil D
author_facet	Young, Neil D Jex, Aaron R Cantacessi, Cinzia Hall, Ross S Hofmann, Andreas Campbell, Bronwyn E Gasser, Robin B Li, Bo Liu, Shiping Yang, Linfeng Xiong, Zijun Li, Yingrui Xu, Xun Chen, Fangyuan Wu, Xuan Zhang, Guojie Fang, Xiaodong Kang, Yi Yang, Huanming Wang, Jun Wang, Jian Zerlotini Neto, Adhemar Oliveira, Guilherme Corrêa de Loukas, Alex Ranganathan, Shoba Rollinson, David Rinaldi, Gabriel Brindley, Paul J
author_role	author
author2	Jex, Aaron R Cantacessi, Cinzia Hall, Ross S Hofmann, Andreas Campbell, Bronwyn E Gasser, Robin B Li, Bo Liu, Shiping Yang, Linfeng Xiong, Zijun Li, Yingrui Xu, Xun Chen, Fangyuan Wu, Xuan Zhang, Guojie Fang, Xiaodong Kang, Yi Yang, Huanming Wang, Jun Wang, Jian Zerlotini Neto, Adhemar Oliveira, Guilherme Corrêa de Loukas, Alex Ranganathan, Shoba Rollinson, David Rinaldi, Gabriel Brindley, Paul J
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Young, Neil D Jex, Aaron R Cantacessi, Cinzia Hall, Ross S Hofmann, Andreas Campbell, Bronwyn E Gasser, Robin B Li, Bo Liu, Shiping Yang, Linfeng Xiong, Zijun Li, Yingrui Xu, Xun Chen, Fangyuan Wu, Xuan Zhang, Guojie Fang, Xiaodong Kang, Yi Yang, Huanming Wang, Jun Wang, Jian Zerlotini Neto, Adhemar Oliveira, Guilherme Corrêa de Hofmann, Andreas Loukas, Alex Ranganathan, Shoba Rollinson, David Rinaldi, Gabriel Brindley, Paul J
dc.subject.en.pt_BR.fl_str_mv	Schistosomiasis blood flukes Praziquantel
topic	Schistosomiasis blood flukes Praziquantel
description	University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
publishDate	2012
dc.date.issued.fl_str_mv	2012
dc.date.accessioned.fl_str_mv	2015-08-19T12:40:07Z
dc.date.available.fl_str_mv	2015-08-19T12:40:07Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	YOUNG, Neil D et al. Whole-genome sequence of Schistosoma haematobium. Nature Genetics, vol.44, n. 2, p. 221-225, 2012.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/11456
dc.identifier.issn.none.fl_str_mv	1061-4036
dc.identifier.doi.none.fl_str_mv	10.1038/ng.1065
identifier_str_mv	YOUNG, Neil D et al. Whole-genome sequence of Schistosoma haematobium. Nature Genetics, vol.44, n. 2, p. 221-225, 2012. 1061-4036 10.1038/ng.1065
url	https://www.arca.fiocruz.br/handle/icict/11456
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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Whole-genome sequence of Schistosoma haematobium

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