Autoimmune thrombocytopenia related to chronic hepatitis C virus infection

Detalhes bibliográficos
Autor(a) principal: Almeida, A. J. de
Data de Publicação: 2009
Outros Autores: Magalhães, M. Campos de, Antonietti, C. L., Mello, C. E. Brandão, Silva, M. L. P. da, Oliveira, R. V. de, Espírito Santo, M. P. do, Yoshida, C. F. T., Lampe, Elisabete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31052
Resumo: 2009-01-01
id CRUZ_dfdd8c3e69f15696d8dcdcb16640a4af
oai_identifier_str oai:www.arca.fiocruz.br:icict/31052
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Almeida, A. J. deMagalhães, M. Campos deAntonietti, C. L.Mello, C. E. BrandãoSilva, M. L. P. daOliveira, R. V. deEspírito Santo, M. P. doYoshida, C. F. T.Lampe, Elisabete2019-01-15T16:14:30Z2019-01-15T16:14:30Z2009ALMEIDA, A. J. de et al. Autoimmune thrombocytopenia related to chronic hepatitis C virus infection. Hematology, v. 14, n. 1, p. 49-58, 2009.1607-8454https://www.arca.fiocruz.br/handle/icict/3105210.1179/102453309X385106engTaylor & FrancisHepatite C crônicaTrombocitopenia autoimunePlaquetasVírus da hepatite CAutoimmune thrombocytopeniaChronic hepatitis CHCVPlateletsAutoimmune thrombocytopenia related to chronic hepatitis C virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2009-01-01Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica B. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica B. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina e Cirurgia. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica B. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Escola de Medicina e Cirurgia. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica A. Unidade de Doenças Hepáticas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.Since the identification of hepatitis C virus (HCV) in 1989 as a causative agent for a number of the extrahepatic alterations related to HCV infection an underlying immune mediated pathogenetic mechanism has been postulated. HCV-associated thrombocytopenia may be considered complex and multifactorial in origin, since different mechanisms have been implicated in its pathophysiology. With respect to autoimmune thrombocytopenia in chronic HCV infection, the detection of specific antibodies against platelet glycoproteins have been reported only in a few studies, but no systematic study has been carried out. We examined the clinical, laboratory, and virological characteristics of a case series of 10 patients with autoimmune thrombocytopenia (platelet count ,150.06109/L) related to chronic HCV infection. Cases, six males and four females, aged 57.1¡12.6 years, presented high titers of antibodies against platelet glycoprotein (GP) IIb/IIIa, GP Ia/IIa, and/or GP Ib/IX, and no other mechanism involved in the pathogenesis of HCV-associated thrombocytopenia was identified. Furthermore, cases were not associated with particular HCV genotype. Complete platelet response was observed in two patients treated with pegylated interferon plus ribavirin, and partial platelet response was seen in two patients treated with anti-D Ig and one patient treated with corticosteroids. These findings indicate that an autoimmune mechanism may play a role in the pathogenesis of HCV-associated thrombocytopenia in a proportion of these patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31052/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMP_espiritosanto_etal_IOC_2009.pdfMP_espiritosanto_etal_IOC_2009.pdfapplication/pdf765499https://www.arca.fiocruz.br/bitstream/icict/31052/2/MP_espiritosanto_etal_IOC_2009.pdfc58c8326ce391046c83f142133c5cda6MD52TEXTMP_espiritosanto_etal_IOC_2009.pdf.txtMP_espiritosanto_etal_IOC_2009.pdf.txtExtracted texttext/plain51060https://www.arca.fiocruz.br/bitstream/icict/31052/3/MP_espiritosanto_etal_IOC_2009.pdf.txtb01693f28e6bbcb79412dfe3d805f0a9MD53icict/310522021-02-10 19:37:59.393oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-02-10T22:37:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
title Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
spellingShingle Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
Almeida, A. J. de
Hepatite C crônica
Trombocitopenia autoimune
Plaquetas
Vírus da hepatite C
Autoimmune thrombocytopenia
Chronic hepatitis C
HCV
Platelets
title_short Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
title_full Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
title_fullStr Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
title_full_unstemmed Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
title_sort Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
author Almeida, A. J. de
author_facet Almeida, A. J. de
Magalhães, M. Campos de
Antonietti, C. L.
Mello, C. E. Brandão
Silva, M. L. P. da
Oliveira, R. V. de
Espírito Santo, M. P. do
Yoshida, C. F. T.
Lampe, Elisabete
author_role author
author2 Magalhães, M. Campos de
Antonietti, C. L.
Mello, C. E. Brandão
Silva, M. L. P. da
Oliveira, R. V. de
Espírito Santo, M. P. do
Yoshida, C. F. T.
Lampe, Elisabete
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, A. J. de
Magalhães, M. Campos de
Antonietti, C. L.
Mello, C. E. Brandão
Silva, M. L. P. da
Oliveira, R. V. de
Espírito Santo, M. P. do
Yoshida, C. F. T.
Lampe, Elisabete
dc.subject.other.pt_BR.fl_str_mv Hepatite C crônica
Trombocitopenia autoimune
Plaquetas
Vírus da hepatite C
topic Hepatite C crônica
Trombocitopenia autoimune
Plaquetas
Vírus da hepatite C
Autoimmune thrombocytopenia
Chronic hepatitis C
HCV
Platelets
dc.subject.en.pt_BR.fl_str_mv Autoimmune thrombocytopenia
Chronic hepatitis C
HCV
Platelets
description 2009-01-01
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-01-15T16:14:30Z
dc.date.available.fl_str_mv 2019-01-15T16:14:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, A. J. de et al. Autoimmune thrombocytopenia related to chronic hepatitis C virus infection. Hematology, v. 14, n. 1, p. 49-58, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31052
dc.identifier.issn.pt_BR.fl_str_mv 1607-8454
dc.identifier.doi.none.fl_str_mv 10.1179/102453309X385106
identifier_str_mv ALMEIDA, A. J. de et al. Autoimmune thrombocytopenia related to chronic hepatitis C virus infection. Hematology, v. 14, n. 1, p. 49-58, 2009.
1607-8454
10.1179/102453309X385106
url https://www.arca.fiocruz.br/handle/icict/31052
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31052/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31052/2/MP_espiritosanto_etal_IOC_2009.pdf
https://www.arca.fiocruz.br/bitstream/icict/31052/3/MP_espiritosanto_etal_IOC_2009.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
c58c8326ce391046c83f142133c5cda6
b01693f28e6bbcb79412dfe3d805f0a9
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008963101261824

Registros relacionados