The Human Hookworm Vaccine

Detalhes bibliográficos
Autor(a) principal: Hotez, Peter Jay
Data de Publicação: 2013
Outros Autores: Diemert, David, Bacon, Kristina M., Beaumier, Coreen, Bethony, Jeffrey Michael, Bottazzi, Maria Elena, Brooker, Simon, Couto, Artur Roberto, Freire, Marcos da Silva, Homma, Akira, Lee, Bruce Y., Loukas, Alex, Loblack, Marva, Morel, Carlos Medicis, Oliveira, Rodrigo Corrêa de, Russell, Philip K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.vaccine.2012.11.034
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30107
Resumo: O artigo encontra-se em acesso aberto no site do Editor.
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spelling Hotez, Peter JayDiemert, DavidBacon, Kristina M.Beaumier, CoreenBethony, Jeffrey MichaelBottazzi, Maria ElenaBrooker, SimonCouto, Artur RobertoFreire, Marcos da SilvaHomma, AkiraLee, Bruce Y.Loukas, AlexLoblack, MarvaMorel, Carlos MedicisOliveira, Rodrigo Corrêa deRussell, Philip K.2018-11-20T11:58:10Z2018-11-20T11:58:10Z2013HOTEZ, Peter Jay et al. The Human Hookworm Vaccine. Vaccine. V. 31, Suppl 2, p. B227-32, 2013.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/3010710.1016/j.vaccine.2012.11.034O artigo encontra-se em acesso aberto no site do Editor.Sabin Vaccine Institute Product Development Partnership. Houston, TX, USA /Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA / Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development. National School of Tropical Medicine. Baylor College of Medicine. Houston, TX, USA / Department of Pediatrics and Molecular Virology and Microbiology. National School of Tropical Medicine. Baylor College of Medicine. Houston, TX, USA.Sabin Vaccine Institute Product Development Partnership. Houston, TX, USA / Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA / Department of Microbiology, Immunology, and Tropical Medicine. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.Public Health Computational and Operations Research. University of Pittsburgh School of Medicine. Pittsburgh, PA, USA.Sabin Vaccine Institute Product Development Partnership. Houston, TX, USA / Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA / Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development. National School of Tropical Medicine. Baylor College of Medicine. Houston, TX, USA / Department of Pediatrics and Molecular Virology and Microbiology. National School of Tropical Medicine. Baylor College of Medicine. Houston, TX, USA.Sabin Vaccine Institute Product Development Partnership. Houston, TX, USA / Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA / Department of Microbiology, Immunology, and Tropical Medicine. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.Sabin Vaccine Institute Product Development Partnership. Houston, TX, USA / Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA / Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development. National School of Tropical Medicine. Baylor College of Medicine. Houston, TX, USA / Department of Pediatrics and Molecular Virology and Microbiology. National School of Tropical Medicine. Baylor College of Medicine. Houston, TX, USA.Faculty of Infectious and Tropical Disease. London School of Hygiene and Tropical Medicine. UK.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, Brasil.Public Health Computational and Operations Research. University of Pittsburgh School of Medicine. Pittsburgh, PA, USA.Queensland Tropical Health Alliance. James Cook University. Cairns, Australia.Sabin Vaccine Institute Product Development Partnership. Houston, TX, United States/Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA.Fundação Oswaldo Cruz. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil.Sabin Vaccine Institute Product Development Partnership. Houston, TX, USA / Sabin Vaccine Institute Product Development Partnership. Washington, DC, USA.Hookworm infection is one of the world's most common neglected tropical diseases and a leading cause of iron deficiency anemia in low- and middle-income countries. A Human Hookworm Vaccine is currently being developed by the Sabin Vaccine Institute and is in phase 1 clinical testing. The candidate vaccine is comprised of two recombinant antigens known as Na-GST-1 and Na-APR-1, each of which is an important parasite enzyme required for hookworms to successfully utilize host blood as a source of energy. The recombinant proteins are formulated on Alhydrogel(®) and are being tested in combination with a synthetic Toll-like receptor 4 agonist. The aim of the vaccine is to induce anti-enzyme antibodies that will reduce both host blood loss and the number of hookworms attached to the gut. Transfer of the manufacturing technology to the Oswaldo Cruz Foundation (FIOCRUZ)/Bio-Manguinhos (a Brazilian public sector developing country vaccine manufacturer) is planned, with a clinical development plan that could lead to registration of the vaccine in Brazil. The vaccine would also need to be introduced in the poorest regions of Africa and Asia, where hookworm infection is highly endemic. Ultimately, the vaccine could become an essential tool for achieving hookworm control and elimination, a key target in the 2012 London Declaration on Neglected Tropical Diseases.engElsevier ScienceAncilóstomoheltmintosNa-GST-1Na-APR-1AnemiaHookwormHelminthNa-GST-1Na-APR-1AnemiaThe Human Hookworm Vaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30107/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALThe Human Hookworm Vaccine.pdfThe Human Hookworm Vaccine.pdfapplication/pdf4617589https://www.arca.fiocruz.br/bitstream/icict/30107/2/The%20Human%20Hookworm%20Vaccine.pdfb05911cbaf8626cf890ab4be001cfe53MD52TEXTThe Human Hookworm Vaccine.pdf.txtThe Human Hookworm Vaccine.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Human Hookworm Vaccine
title The Human Hookworm Vaccine
spellingShingle The Human Hookworm Vaccine
Hotez, Peter Jay
Ancilóstomo
heltmintos
Na-GST-1
Na-APR-1
Anemia
Hookworm
Helminth
Na-GST-1
Na-APR-1
Anemia
title_short The Human Hookworm Vaccine
title_full The Human Hookworm Vaccine
title_fullStr The Human Hookworm Vaccine
title_full_unstemmed The Human Hookworm Vaccine
title_sort The Human Hookworm Vaccine
author Hotez, Peter Jay
author_facet Hotez, Peter Jay
Diemert, David
Bacon, Kristina M.
Beaumier, Coreen
Bethony, Jeffrey Michael
Bottazzi, Maria Elena
Brooker, Simon
Couto, Artur Roberto
Freire, Marcos da Silva
Homma, Akira
Lee, Bruce Y.
Loukas, Alex
Loblack, Marva
Morel, Carlos Medicis
Oliveira, Rodrigo Corrêa de
Russell, Philip K.
author_role author
author2 Diemert, David
Bacon, Kristina M.
Beaumier, Coreen
Bethony, Jeffrey Michael
Bottazzi, Maria Elena
Brooker, Simon
Couto, Artur Roberto
Freire, Marcos da Silva
Homma, Akira
Lee, Bruce Y.
Loukas, Alex
Loblack, Marva
Morel, Carlos Medicis
Oliveira, Rodrigo Corrêa de
Russell, Philip K.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hotez, Peter Jay
Diemert, David
Bacon, Kristina M.
Beaumier, Coreen
Bethony, Jeffrey Michael
Bottazzi, Maria Elena
Brooker, Simon
Couto, Artur Roberto
Freire, Marcos da Silva
Homma, Akira
Lee, Bruce Y.
Loukas, Alex
Loblack, Marva
Morel, Carlos Medicis
Oliveira, Rodrigo Corrêa de
Russell, Philip K.
dc.subject.other.pt_BR.fl_str_mv Ancilóstomo
heltmintos
Na-GST-1
Na-APR-1
Anemia
topic Ancilóstomo
heltmintos
Na-GST-1
Na-APR-1
Anemia
Hookworm
Helminth
Na-GST-1
Na-APR-1
Anemia
dc.subject.en.pt_BR.fl_str_mv Hookworm
Helminth
Na-GST-1
Na-APR-1
Anemia
description O artigo encontra-se em acesso aberto no site do Editor.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-11-20T11:58:10Z
dc.date.available.fl_str_mv 2018-11-20T11:58:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HOTEZ, Peter Jay et al. The Human Hookworm Vaccine. Vaccine. V. 31, Suppl 2, p. B227-32, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30107
dc.identifier.issn.pt_BR.fl_str_mv 0264-410X
dc.identifier.doi.none.fl_str_mv 10.1016/j.vaccine.2012.11.034
identifier_str_mv HOTEZ, Peter Jay et al. The Human Hookworm Vaccine. Vaccine. V. 31, Suppl 2, p. B227-32, 2013.
0264-410X
10.1016/j.vaccine.2012.11.034
url https://www.arca.fiocruz.br/handle/icict/30107
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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