Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum

Detalhes bibliográficos
Autor(a) principal: Losada-Barragán, Monica
Data de Publicação: 2017
Outros Autores: Umaña-Pérez, Adriana, Cuervo-Escobar, Sergio, Berbert, Luiz Ricardo, Porrozzi, Renato, Morgado, Fernanda N., Cruz, Daniella Arêas Mendes da, Savino, Wilson, Sánchez-Gómez, Myriam, Cuervo, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1038/srep45991
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18775
Resumo: Erratum: Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum Monica Losada-Barragán, Adriana Umaña-Pérez, Sergio Cuervo-Escobar, Luiz Ricardo Berbert, Renato Porrozzi, Fernanda N. Morgado, Daniella Areas Mendes-da-Cruz, Wilson Savino, Myriam Sánchez-Gómez & Patricia Cuervo Scientific Reports 7:45991; published online 11 April 2017; updated on 25 September 2017 In this Article, Figure 4 is incorrect. The correct Figure 4 appears below as Figure 1. The legend of Figure 4 was correct from the time of publication.
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spelling Losada-Barragán, MonicaUmaña-Pérez, AdrianaCuervo-Escobar, SergioBerbert, Luiz RicardoPorrozzi, RenatoMorgado, Fernanda N.Cruz, Daniella Arêas Mendes daSavino, WilsonSánchez-Gómez, MyriamCuervo, Patricia2017-05-06T14:50:06Z2017-05-06T14:50:06Z2017LOSADA-BARRAGÁN, Monica et al. Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum. Scientific Reports, v. 7, p. 1-13, Apr. 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/1877510.1038/srep459912045-2322Erratum: Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum Monica Losada-Barragán, Adriana Umaña-Pérez, Sergio Cuervo-Escobar, Luiz Ricardo Berbert, Renato Porrozzi, Fernanda N. Morgado, Daniella Areas Mendes-da-Cruz, Wilson Savino, Myriam Sánchez-Gómez & Patricia Cuervo Scientific Reports 7:45991; published online 11 April 2017; updated on 25 September 2017 In this Article, Figure 4 is incorrect. The correct Figure 4 appears below as Figure 1. The legend of Figure 4 was correct from the time of publication.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Universidad Nacional de Colombia. Sede Bogotá. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.Universidad Nacional de Colombia. Sede Bogotá. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidad Nacional de Colombia. Sede Bogotá. Facultad de Ciencias. Departamento de Química. Grupo de Investigación en Hormonas. Bogotá, Colombia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Protein malnutrition, the most deleterious cause of malnutrition in developing countries, has been considered a primary risk factor for the development of clinical visceral leishmaniasis (VL). Protein malnutrition and infection with Leishmania infantum leads to lymphoid tissue disorganization, including changes in cellularity and lymphocyte subpopulations in the thymus and spleen. Here we report that protein malnutrition modifies thymic chemotactic factors by diminishing the CCL5, CXCL12, IGF1, CXCL9 and CXCL10 protein levels in infected animals. Nevertheless, T cells preserve their migratory capability, as they were able to migrate ex vivo in response to chemotactic stimuli, indicating that malnutrition may compromise the thymic microenvironment and alter in vivo thymocyte migration. Decrease in chemotactic factors protein levels was accompanied by an early increase in the parasite load of the spleen. These results suggest that the precondition of malnutrition is affecting the cell-mediated immune response to L. infantum by altering T cell migration and interfering with the capacity of protein-deprived animals to control parasite spreading and proliferation. Our data provide evidence for a disturbance of T lymphocyte migration involving both central and peripheral T-cells, which likely contribute to the pathophysiology of VL that occurs in malnourished individuals.engNature Publishing GroupTimoLeishmaniose visceralMigração de células TCarência de proteínaLeishmania infantumLeishmania infantumThymusT cell migrationProtein malnutritionVisceral leishmaniasisProtein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
title Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
spellingShingle Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
Losada-Barragán, Monica
Timo
Leishmaniose visceral
Migração de células T
Carência de proteína
Leishmania infantum
Leishmania infantum
Thymus
T cell migration
Protein malnutrition
Visceral leishmaniasis
title_short Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
title_full Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
title_fullStr Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
title_full_unstemmed Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
title_sort Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum
author Losada-Barragán, Monica
author_facet Losada-Barragán, Monica
Umaña-Pérez, Adriana
Cuervo-Escobar, Sergio
Berbert, Luiz Ricardo
Porrozzi, Renato
Morgado, Fernanda N.
Cruz, Daniella Arêas Mendes da
Savino, Wilson
Sánchez-Gómez, Myriam
Cuervo, Patricia
author_role author
author2 Umaña-Pérez, Adriana
Cuervo-Escobar, Sergio
Berbert, Luiz Ricardo
Porrozzi, Renato
Morgado, Fernanda N.
Cruz, Daniella Arêas Mendes da
Savino, Wilson
Sánchez-Gómez, Myriam
Cuervo, Patricia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Losada-Barragán, Monica
Umaña-Pérez, Adriana
Cuervo-Escobar, Sergio
Berbert, Luiz Ricardo
Porrozzi, Renato
Morgado, Fernanda N.
Cruz, Daniella Arêas Mendes da
Savino, Wilson
Sánchez-Gómez, Myriam
Cuervo, Patricia
dc.subject.other.pt_BR.fl_str_mv Timo
Leishmaniose visceral
Migração de células T
Carência de proteína
Leishmania infantum
topic Timo
Leishmaniose visceral
Migração de células T
Carência de proteína
Leishmania infantum
Leishmania infantum
Thymus
T cell migration
Protein malnutrition
Visceral leishmaniasis
dc.subject.en.pt_BR.fl_str_mv Leishmania infantum
Thymus
T cell migration
Protein malnutrition
Visceral leishmaniasis
description Erratum: Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum Monica Losada-Barragán, Adriana Umaña-Pérez, Sergio Cuervo-Escobar, Luiz Ricardo Berbert, Renato Porrozzi, Fernanda N. Morgado, Daniella Areas Mendes-da-Cruz, Wilson Savino, Myriam Sánchez-Gómez & Patricia Cuervo Scientific Reports 7:45991; published online 11 April 2017; updated on 25 September 2017 In this Article, Figure 4 is incorrect. The correct Figure 4 appears below as Figure 1. The legend of Figure 4 was correct from the time of publication.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-05-06T14:50:06Z
dc.date.available.fl_str_mv 2017-05-06T14:50:06Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LOSADA-BARRAGÁN, Monica et al. Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum. Scientific Reports, v. 7, p. 1-13, Apr. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18775
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/srep45991
dc.identifier.eissn.none.fl_str_mv 2045-2322
identifier_str_mv LOSADA-BARRAGÁN, Monica et al. Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum. Scientific Reports, v. 7, p. 1-13, Apr. 2017.
2045-2322
10.1038/srep45991
url https://www.arca.fiocruz.br/handle/icict/18775
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