T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10646 |
Resumo: | CNPq, Departamento Administrativo de Ciencia, Tecnología e Innovación, FIOCRUZ, National University of Colombia Research Council |
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Escobar, Sergio CuervoBarragán, Monica LosadaPérez, Adriana UmañaPorrozzi, RenatoVahia, Leonardo SaboiaMiranda, Luisa Helena Monteiro deMorgado, Fernanda NazaréMenezes, Rodrigo CaldasGómez, Myriam SánchezCuervo, Patricia2015-06-03T17:56:21Z2015-06-03T17:56:21Z2014ESCOBAR, Sergio Cuervo et al. T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum. Plos One, v.9, n.12, p.e114584, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1064610.1371/journal.pone.01145841932-6203CNPq, Departamento Administrativo de Ciencia, Tecnología e Innovación, FIOCRUZ, National University of Colombia Research CouncilUniversidad Nacional de Colombia. Laboratorio de Hormonas. Departamento de QuÍmica. Bogotá, ColômbiaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilUniversidad Nacional de Colombia. Laboratorio de Hormonas. Departamento de QuÍmica. Bogotá, ColômbiaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilUniversidad Nacional de Colombia. Laboratorio de Hormonas. Departamento de QuÍmica. Bogotá, ColômbiaFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, BrasilVisceral leishmaniasis (VL) is a parasitic infectious disease that causes significant morbidity and mortality in the tropical and subtropical regions of the world. Although infections with visceralizing Leishmania may be asymptomatic, factors such as undernutrition increase the likelihood of progressing to clinical disease. Protein malnutrition, the most deleterious cause of malnutrition in developing countries, has been considered as a primary risk factor for the development of clinical VL. However, data regarding the immunological basis of this association are scarce. With the aim to analyze the effects of protein malnutrition on Leishmania infantum infection, we used BALB/c mice subjected to control or low protein isocaloric diets. Each animal group was divided into two subgroups and one was infected with L. infantum resulting in four study groups: animals fed 14% protein diet (CP), animals fed 4% protein diet (LP), animals fed 14% protein diet and infected (CPi), and animals fed 4% protein diet and infected (LPi).The susceptibility to L. infantum infection and immune responses were assessed in terms of body and lymphoid organ weight, parasite load, lymphocyte subpopulations, and cytokine expression. LPi mice had a significant reduction of body and lymphoid organ weight and exhibited a severe decrease of lymphoid follicles in the spleen. Moreover, LPi animals showed a significant decrease in CD4+CD8+ Tcells in the thymus, whereas there was an increase of CD4+ and CD8+ T cells percentages in the spleen. Notably, the cytokine mRNA levels in the thymus and spleen of protein malnourished-infected animals were altered compared to the CP mice. Protein malnutrition results in a drastic dysregulation of T cells and cytokine expression in the thymus and spleen of L. infantum-infected BALB/c mice, which may lead to defective regulation of the thymocyte population and an impaired splenic immune response, accelerating the events of a normal course of infection.engPublic Library of ScienceT-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmania infantumLeishmaniasis, VisceralAntigens, CD4Antigens, CD8Leishmania infantumLeishmaniose VisceralAntígenos CD4Antígenos CD8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10646/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALT-Cell Populations and Cytokine Expression Are Impaired in Thymus and Spleen of Protein Malnourished BALBc Mice Infected with Leishmania infantum.pdfT-Cell Populations and Cytokine Expression Are Impaired in Thymus and Spleen of Protein Malnourished BALBc Mice Infected with Leishmania infantum.pdfapplication/pdf3599520https://www.arca.fiocruz.br/bitstream/icict/10646/2/T-Cell%20Populations%20and%20Cytokine%20Expression%20Are%20Impaired%20in%20Thymus%20and%20Spleen%20of%20Protein%20Malnourished%20BALBc%20Mice%20Infected%20with%20Leishmania%20infantum.pdffcd522e296d0d4d7058add3893e04f85MD52TEXTT-Cell Populations and Cytokine Expression Are Impaired in Thymus and Spleen of Protein Malnourished BALBc Mice Infected with Leishmania infantum.pdf.txtT-Cell Populations and Cytokine Expression Are Impaired in Thymus and Spleen of Protein Malnourished BALBc Mice Infected with Leishmania infantum.pdf.txtExtracted texttext/plain61751https://www.arca.fiocruz.br/bitstream/icict/10646/3/T-Cell%20Populations%20and%20Cytokine%20Expression%20Are%20Impaired%20in%20Thymus%20and%20Spleen%20of%20Protein%20Malnourished%20BALBc%20Mice%20Infected%20with%20Leishmania%20infantum.pdf.txt38e45490e948569bee180f7044396d61MD53icict/106462023-09-05 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| dc.title.pt_BR.fl_str_mv |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| title |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| spellingShingle |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum Escobar, Sergio Cuervo Leishmania infantum Leishmaniasis, Visceral Antigens, CD4 Antigens, CD8 Leishmania infantum Leishmaniose Visceral Antígenos CD4 Antígenos CD8 |
| title_short |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| title_full |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| title_fullStr |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| title_full_unstemmed |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| title_sort |
T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum |
| author |
Escobar, Sergio Cuervo |
| author_facet |
Escobar, Sergio Cuervo Barragán, Monica Losada Pérez, Adriana Umaña Porrozzi, Renato Vahia, Leonardo Saboia Miranda, Luisa Helena Monteiro de Morgado, Fernanda Nazaré Menezes, Rodrigo Caldas Gómez, Myriam Sánchez Cuervo, Patricia |
| author_role |
author |
| author2 |
Barragán, Monica Losada Pérez, Adriana Umaña Porrozzi, Renato Vahia, Leonardo Saboia Miranda, Luisa Helena Monteiro de Morgado, Fernanda Nazaré Menezes, Rodrigo Caldas Gómez, Myriam Sánchez Cuervo, Patricia |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Escobar, Sergio Cuervo Barragán, Monica Losada Pérez, Adriana Umaña Porrozzi, Renato Vahia, Leonardo Saboia Miranda, Luisa Helena Monteiro de Morgado, Fernanda Nazaré Menezes, Rodrigo Caldas Gómez, Myriam Sánchez Cuervo, Patricia |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania infantum Leishmaniasis, Visceral Antigens, CD4 Antigens, CD8 |
| topic |
Leishmania infantum Leishmaniasis, Visceral Antigens, CD4 Antigens, CD8 Leishmania infantum Leishmaniose Visceral Antígenos CD4 Antígenos CD8 |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmania infantum Leishmaniose Visceral Antígenos CD4 Antígenos CD8 |
| description |
CNPq, Departamento Administrativo de Ciencia, Tecnología e Innovación, FIOCRUZ, National University of Colombia Research Council |
| publishDate |
2014 |
| dc.date.issued.fl_str_mv |
2014 |
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2015-06-03T17:56:21Z |
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2015-06-03T17:56:21Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ESCOBAR, Sergio Cuervo et al. T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum. Plos One, v.9, n.12, p.e114584, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10646 |
| dc.identifier.issn.none.fl_str_mv |
1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0114584 |
| dc.identifier.eissn.none.fl_str_mv |
1932-6203 |
| identifier_str_mv |
ESCOBAR, Sergio Cuervo et al. T-cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished BALB/c mice infected with leishmania infantum. Plos One, v.9, n.12, p.e114584, 2014. 1932-6203 10.1371/journal.pone.0114584 |
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https://www.arca.fiocruz.br/handle/icict/10646 |
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eng |
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eng |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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