Role of sand fly saliva in human and experimental leishmaniasis: current insights.

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno de Bezerril
Data de Publicação: 2007
Outros Autores: Oliveira, Camila Indiani de, Brodskyn, Claudia Ida, Barral, Aldina Maria Prado, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/j.1365-3083.2007.01964.x
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7410
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Bruno de BezerrilOliveira, Camila Indiani deBrodskyn, Claudia IdaBarral, Aldina Maria PradoBarral Netto, Manoel2014-03-17T16:41:36Z2014-03-17T16:41:36Z2007ANDRADE, B. B. et al. Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scandinavian Journal of Immunology, v. 66, n. 2-3, p. 122–127, 2007.0300-9475https://www.arca.fiocruz.br/handle/icict/741010.1111/j.1365-3083.2007.01964.xengBlackwell Publishing LtdRole of sand fly saliva in human and experimental leishmaniasis: current insights.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, BrasilLeishmaniases are wide spread diseases transmitted to their vertebrate host by infected sand fly. The saliva from these arthropods contains a vast repertoire of pharmacologically active molecules that hampers the host’s haemostatic, inflammatory and immune responses. The early interactions between Leishmania and the host’s immune response are closely linked to disease evolution or protection against the protozoan, and the ectoparasite saliva contributes directly to these interactions. Current studies have depicted these features, and these relations are being widely explored. There are concrete indications that the host response against sand fly saliva influences disease outcome in leishmaniasis. Additionally, there are demonstrations that immunization with whole sand fly saliva, or its components, leads to protection against leishmaniasis in different host species. The combination of these evidences opens up optimistic perspectives for improving vaccine development against Leishmania infection.Leishmania/crescimento & desenvolvimentoLeishmania/imunologiaLeishmaniose/imunologiaLeishmaniose/parasitologiaPsychodidae/imunologiaPsychodidae/parasitologiaSaliva/imunologiaSaliva/parasitologiaAnimaisModelos Animais de DoençasHumanosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade BB Role of sand....pdfAndrade BB Role of sand....pdfapplication/pdf615516https://www.arca.fiocruz.br/bitstream/icict/7410/1/Andrade%20BB%20Role%20of%20sand....pdffad0edb48a7f0d10491965bfc00bc582MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7410/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAndrade BB Role of sand....pdf.txtAndrade BB Role of sand....pdf.txtExtracted texttext/plain32570https://www.arca.fiocruz.br/bitstream/icict/7410/5/Andrade%20BB%20Role%20of%20sand....pdf.txtfaffa2dd04388c9375efcba531a87f8cMD55THUMBNAILAndrade BB Role of sand....pdf.jpgAndrade BB Role of sand....pdf.jpgGenerated Thumbnailimage/jpeg2494https://www.arca.fiocruz.br/bitstream/icict/7410/4/Andrade%20BB%20Role%20of%20sand....pdf.jpga0a2cce4a2ccf7222ad9cf2e78a0b790MD54icict/74102023-03-15 14:33:22.143oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Role of sand fly saliva in human and experimental leishmaniasis: current insights.
title Role of sand fly saliva in human and experimental leishmaniasis: current insights.
spellingShingle Role of sand fly saliva in human and experimental leishmaniasis: current insights.
Andrade, Bruno de Bezerril
Leishmania/crescimento & desenvolvimento
Leishmania/imunologia
Leishmaniose/imunologia
Leishmaniose/parasitologia
Psychodidae/imunologia
Psychodidae/parasitologia
Saliva/imunologia
Saliva/parasitologia
Animais
Modelos Animais de Doenças
Humanos
title_short Role of sand fly saliva in human and experimental leishmaniasis: current insights.
title_full Role of sand fly saliva in human and experimental leishmaniasis: current insights.
title_fullStr Role of sand fly saliva in human and experimental leishmaniasis: current insights.
title_full_unstemmed Role of sand fly saliva in human and experimental leishmaniasis: current insights.
title_sort Role of sand fly saliva in human and experimental leishmaniasis: current insights.
author Andrade, Bruno de Bezerril
author_facet Andrade, Bruno de Bezerril
Oliveira, Camila Indiani de
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Barral Netto, Manoel
author_role author
author2 Oliveira, Camila Indiani de
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Barral Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno de Bezerril
Oliveira, Camila Indiani de
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Barral Netto, Manoel
dc.subject.decs.pt_BR.fl_str_mv Leishmania/crescimento & desenvolvimento
Leishmania/imunologia
Leishmaniose/imunologia
Leishmaniose/parasitologia
Psychodidae/imunologia
Psychodidae/parasitologia
Saliva/imunologia
Saliva/parasitologia
Animais
Modelos Animais de Doenças
Humanos
topic Leishmania/crescimento & desenvolvimento
Leishmania/imunologia
Leishmaniose/imunologia
Leishmaniose/parasitologia
Psychodidae/imunologia
Psychodidae/parasitologia
Saliva/imunologia
Saliva/parasitologia
Animais
Modelos Animais de Doenças
Humanos
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-03-17T16:41:36Z
dc.date.available.fl_str_mv 2014-03-17T16:41:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ANDRADE, B. B. et al. Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scandinavian Journal of Immunology, v. 66, n. 2-3, p. 122–127, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7410
dc.identifier.issn.none.fl_str_mv 0300-9475
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-3083.2007.01964.x
identifier_str_mv ANDRADE, B. B. et al. Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scandinavian Journal of Immunology, v. 66, n. 2-3, p. 122–127, 2007.
0300-9475
10.1111/j.1365-3083.2007.01964.x
url https://www.arca.fiocruz.br/handle/icict/7410
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dc.publisher.none.fl_str_mv Blackwell Publishing Ltd
publisher.none.fl_str_mv Blackwell Publishing Ltd
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