Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain

Detalhes bibliográficos
Autor(a) principal: Trevinõ, Ana
Data de Publicação: 2014
Outros Autores: Alcantara, Luiz Carlos Júnior, Benito, Rafael, Caballero, Estrella, Aguilera, Antonio, Ramos, José Manuel, Mendoza, Carmen de, Rodríguez, Carmen, García, Juan, Iglesias, Manuel Rodrguez, Lejarazu, Raúl Ortiz de, Roc, Lourdes, Parra, Patricia, Eiros, José, del Romero, Jorge, Soriano, Vincent, HTLV Spanish Study Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8463
Resumo: Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
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spelling Trevinõ, AnaAlcantara, Luiz Carlos JúniorBenito, RafaelCaballero, EstrellaAguilera, AntonioRamos, José ManuelMendoza, Carmen deRodríguez, CarmenGarcía, JuanIglesias, Manuel RodrguezLejarazu, Raúl Ortiz deRoc, LourdesParra, PatriciaEiros, Josédel Romero, JorgeSoriano, VincentHTLV Spanish Study Group2014-09-29T12:43:14Z2014-09-29T12:43:14Z2014TREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 20140889-2229https://www.arca.fiocruz.br/handle/icict/846310.1089/aid.2013.0128engMary Ann Liebert, IncHTLV-IRelações sexuaisMasculinoFemininoAdultoMielopatia associada ao HTLV-ILeucemiaLinfoma de célulasMolecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spaininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Carlos III. Infectious Diseases Department. Madrid, SpainFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Clínico Universitario Lozano Blesa. Service of Microbiology. Zaragoza, SpainHospital Vall d’Hebron. Service of Microbiology. Barcelona, SpainHospital Conxo-CHUS. Service of Microbiology. Santiago, SpainHospital General de Elche. Infectious Disease Unit. Elche, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainCentro Sanitario Sandoval. Madrid, SpainHospital Cristal-Piñor. Service of Microbiology. Orense, SpainHospital Universitario Puerta del Mar. Service of Microbiology. Cádiz, SpainHospital Clínico Universitario. Service of Microbiology. Valladolid, SpainHospital Miguel Servet. Service of Microbiology. Zaragoza, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainHospital Clínico Universitario. Service of Microbiology. Valladolid, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainHTLV Spanish Study GroupHuman T cell lymphotropic virus type 1 (HTLV-1) infection in Spain is rare and mainly affects immigrants from endemic regions and native Spaniards with a prior history of sexual intercourse with persons from endemic countries. Herein, we report the main clinical and virological features of cases reported in Spain. All individuals with HTLV-1 infection recorded at the national registry since 1989 were examined. Phylogenetic analysis was performed based on the long terminal repeat (LTR) region. A total of 229 HTLV-1 cases had been reported up to December 2012. The mean age was 41 years old and 61% were female. Their country of origin was Latin America in 59%, Africa in 15%, and Spain in 20%. Transmission had occurred following sexual contact in 41%, parenteral exposure in 12%, and vertically in 9%. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was diagnosed in 27 cases and adult T cell leukemia/lymphoma (ATLL) in 17 subjects. HTLV-1 subtype could be obtained for 45 patients; all but one belonged to the Cosmopolitan subtype a. One Nigerian pregnant woman harbored HTLV-1 subtype b. Within the Cosmopolitan subtype a, two individuals (from Bolivia and Peru, respectively) belonged to the Japanese subgroup B, another two (from Senegal and Mauritania) to the North African subgroup D, and 39 to the Transcontinental subgroup A. Of note, one divergent HTLV-1 strain from an Ethiopian branched off from all five known Cosmopolitan subtype 1a subgroups. Divergent HTLV-1 strains have been introduced and currently circulate in Spain. The relatively large proportion of symptomatic cases (19%) suggests that HTLV-1 infection is underdiagnosed in Spain.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8463/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALTrevino A Molecular epidemiology....pdfTrevino A Molecular epidemiology....pdfapplication/pdf320293https://www.arca.fiocruz.br/bitstream/icict/8463/2/Trevino%20A%20Molecular%20epidemiology....pdf57b282423019ac5a283f3044273bc979MD52TEXTTrevino A Molecular epidemiology....pdf.txtTrevino A Molecular epidemiology....pdf.txtExtracted texttext/plain29229https://www.arca.fiocruz.br/bitstream/icict/8463/3/Trevino%20A%20Molecular%20epidemiology....pdf.txt98acc27d563d2db9adf4e0099d596275MD53icict/84632023-03-15 14:33:23.465oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
title Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
spellingShingle Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
Trevinõ, Ana
HTLV-I
Relações sexuais
Masculino
Feminino
Adulto
Mielopatia associada ao HTLV-I
Leucemia
Linfoma de células
title_short Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
title_full Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
title_fullStr Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
title_full_unstemmed Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
title_sort Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
author Trevinõ, Ana
author_facet Trevinõ, Ana
Alcantara, Luiz Carlos Júnior
Benito, Rafael
Caballero, Estrella
Aguilera, Antonio
Ramos, José Manuel
Mendoza, Carmen de
Rodríguez, Carmen
García, Juan
Iglesias, Manuel Rodrguez
Lejarazu, Raúl Ortiz de
Roc, Lourdes
Parra, Patricia
Eiros, José
del Romero, Jorge
Soriano, Vincent
HTLV Spanish Study Group
author_role author
author2 Alcantara, Luiz Carlos Júnior
Benito, Rafael
Caballero, Estrella
Aguilera, Antonio
Ramos, José Manuel
Mendoza, Carmen de
Rodríguez, Carmen
García, Juan
Iglesias, Manuel Rodrguez
Lejarazu, Raúl Ortiz de
Roc, Lourdes
Parra, Patricia
Eiros, José
del Romero, Jorge
Soriano, Vincent
HTLV Spanish Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Trevinõ, Ana
Alcantara, Luiz Carlos Júnior
Benito, Rafael
Caballero, Estrella
Aguilera, Antonio
Ramos, José Manuel
Mendoza, Carmen de
Rodríguez, Carmen
García, Juan
Iglesias, Manuel Rodrguez
Lejarazu, Raúl Ortiz de
Roc, Lourdes
Parra, Patricia
Eiros, José
del Romero, Jorge
Soriano, Vincent
HTLV Spanish Study Group
dc.subject.other.pt_BR.fl_str_mv HTLV-I
Relações sexuais
Masculino
Feminino
Adulto
Mielopatia associada ao HTLV-I
Leucemia
Linfoma de células
topic HTLV-I
Relações sexuais
Masculino
Feminino
Adulto
Mielopatia associada ao HTLV-I
Leucemia
Linfoma de células
description Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-09-29T12:43:14Z
dc.date.available.fl_str_mv 2014-09-29T12:43:14Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 2014
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8463
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/aid.2013.0128
identifier_str_mv TREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 2014
0889-2229
10.1089/aid.2013.0128
url https://www.arca.fiocruz.br/handle/icict/8463
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc
publisher.none.fl_str_mv Mary Ann Liebert, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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