Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8463 |
Resumo: | Hospital Carlos III. Infectious Diseases Department. Madrid, Spain |
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Trevinõ, AnaAlcantara, Luiz Carlos JúniorBenito, RafaelCaballero, EstrellaAguilera, AntonioRamos, José ManuelMendoza, Carmen deRodríguez, CarmenGarcía, JuanIglesias, Manuel RodrguezLejarazu, Raúl Ortiz deRoc, LourdesParra, PatriciaEiros, Josédel Romero, JorgeSoriano, VincentHTLV Spanish Study Group2014-09-29T12:43:14Z2014-09-29T12:43:14Z2014TREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 20140889-2229https://www.arca.fiocruz.br/handle/icict/846310.1089/aid.2013.0128engMary Ann Liebert, IncHTLV-IRelações sexuaisMasculinoFemininoAdultoMielopatia associada ao HTLV-ILeucemiaLinfoma de célulasMolecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spaininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Carlos III. Infectious Diseases Department. Madrid, SpainFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHospital Clínico Universitario Lozano Blesa. Service of Microbiology. Zaragoza, SpainHospital Vall d’Hebron. Service of Microbiology. Barcelona, SpainHospital Conxo-CHUS. Service of Microbiology. Santiago, SpainHospital General de Elche. Infectious Disease Unit. Elche, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainCentro Sanitario Sandoval. Madrid, SpainHospital Cristal-Piñor. Service of Microbiology. Orense, SpainHospital Universitario Puerta del Mar. Service of Microbiology. Cádiz, SpainHospital Clínico Universitario. Service of Microbiology. Valladolid, SpainHospital Miguel Servet. Service of Microbiology. Zaragoza, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainHospital Clínico Universitario. Service of Microbiology. Valladolid, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainHospital Carlos III. Infectious Diseases Department. Madrid, SpainHTLV Spanish Study GroupHuman T cell lymphotropic virus type 1 (HTLV-1) infection in Spain is rare and mainly affects immigrants from endemic regions and native Spaniards with a prior history of sexual intercourse with persons from endemic countries. Herein, we report the main clinical and virological features of cases reported in Spain. All individuals with HTLV-1 infection recorded at the national registry since 1989 were examined. Phylogenetic analysis was performed based on the long terminal repeat (LTR) region. A total of 229 HTLV-1 cases had been reported up to December 2012. The mean age was 41 years old and 61% were female. Their country of origin was Latin America in 59%, Africa in 15%, and Spain in 20%. Transmission had occurred following sexual contact in 41%, parenteral exposure in 12%, and vertically in 9%. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was diagnosed in 27 cases and adult T cell leukemia/lymphoma (ATLL) in 17 subjects. HTLV-1 subtype could be obtained for 45 patients; all but one belonged to the Cosmopolitan subtype a. One Nigerian pregnant woman harbored HTLV-1 subtype b. Within the Cosmopolitan subtype a, two individuals (from Bolivia and Peru, respectively) belonged to the Japanese subgroup B, another two (from Senegal and Mauritania) to the North African subgroup D, and 39 to the Transcontinental subgroup A. Of note, one divergent HTLV-1 strain from an Ethiopian branched off from all five known Cosmopolitan subtype 1a subgroups. Divergent HTLV-1 strains have been introduced and currently circulate in Spain. The relatively large proportion of symptomatic cases (19%) suggests that HTLV-1 infection is underdiagnosed in Spain.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8463/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALTrevino A Molecular epidemiology....pdfTrevino A Molecular epidemiology....pdfapplication/pdf320293https://www.arca.fiocruz.br/bitstream/icict/8463/2/Trevino%20A%20Molecular%20epidemiology....pdf57b282423019ac5a283f3044273bc979MD52TEXTTrevino A Molecular epidemiology....pdf.txtTrevino A Molecular epidemiology....pdf.txtExtracted texttext/plain29229https://www.arca.fiocruz.br/bitstream/icict/8463/3/Trevino%20A%20Molecular%20epidemiology....pdf.txt98acc27d563d2db9adf4e0099d596275MD53icict/84632023-03-15 14:33:23.465oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| title |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| spellingShingle |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain Trevinõ, Ana HTLV-I Relações sexuais Masculino Feminino Adulto Mielopatia associada ao HTLV-I Leucemia Linfoma de células |
| title_short |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| title_full |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| title_fullStr |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| title_full_unstemmed |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| title_sort |
Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain |
| author |
Trevinõ, Ana |
| author_facet |
Trevinõ, Ana Alcantara, Luiz Carlos Júnior Benito, Rafael Caballero, Estrella Aguilera, Antonio Ramos, José Manuel Mendoza, Carmen de Rodríguez, Carmen García, Juan Iglesias, Manuel Rodrguez Lejarazu, Raúl Ortiz de Roc, Lourdes Parra, Patricia Eiros, José del Romero, Jorge Soriano, Vincent HTLV Spanish Study Group |
| author_role |
author |
| author2 |
Alcantara, Luiz Carlos Júnior Benito, Rafael Caballero, Estrella Aguilera, Antonio Ramos, José Manuel Mendoza, Carmen de Rodríguez, Carmen García, Juan Iglesias, Manuel Rodrguez Lejarazu, Raúl Ortiz de Roc, Lourdes Parra, Patricia Eiros, José del Romero, Jorge Soriano, Vincent HTLV Spanish Study Group |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Trevinõ, Ana Alcantara, Luiz Carlos Júnior Benito, Rafael Caballero, Estrella Aguilera, Antonio Ramos, José Manuel Mendoza, Carmen de Rodríguez, Carmen García, Juan Iglesias, Manuel Rodrguez Lejarazu, Raúl Ortiz de Roc, Lourdes Parra, Patricia Eiros, José del Romero, Jorge Soriano, Vincent HTLV Spanish Study Group |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-I Relações sexuais Masculino Feminino Adulto Mielopatia associada ao HTLV-I Leucemia Linfoma de células |
| topic |
HTLV-I Relações sexuais Masculino Feminino Adulto Mielopatia associada ao HTLV-I Leucemia Linfoma de células |
| description |
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain |
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2014 |
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2014-09-29T12:43:14Z |
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2014-09-29T12:43:14Z |
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2014 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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TREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 2014 |
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https://www.arca.fiocruz.br/handle/icict/8463 |
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0889-2229 |
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10.1089/aid.2013.0128 |
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TREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 2014 0889-2229 10.1089/aid.2013.0128 |
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Mary Ann Liebert, Inc |
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Mary Ann Liebert, Inc |
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