Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study

Detalhes bibliográficos
Autor(a) principal: Soares, Emmanuel Alves
Data de Publicação: 2019
Outros Autores: Lazera, Márcia dos Santos, Wanke, Bodo, Ferreira, Marcela de Faria, Oliveira, Raquel de Vasconcellos Carvalhaes de, Oliveira, Adeno Gonçalves, Coutinho, Ziadir Francisco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35495
Resumo: State Secretary of Health of Piauí. Natan Portela Institute of Tropical Diseases. Departament of infectious disease. Teresina, PI, Brazil.
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spelling Soares, Emmanuel AlvesLazera, Márcia dos SantosWanke, BodoFerreira, Marcela de FariaOliveira, Raquel de Vasconcellos Carvalhaes deOliveira, Adeno GonçalvesCoutinho, Ziadir Francisco2019-09-11T14:04:04Z2019-09-11T14:04:04Z2019SOARES, Emmanuel Alves et al. Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study. Plos Neglected Tropical Diseases, p. 1-17, July 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3549510.1371/journal.pntd.00075691935-2727engPublic Library of ScienceMortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleState Secretary of Health of Piauí. Natan Portela Institute of Tropical Diseases. Departament of infectious disease. Teresina, PI, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.State Secretary of Health of Piauí. Natan Portela Institute of Tropical Diseases. Departament of infectious disease. Teresina, PI, Brazil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Centro de Saúde Escola Germano Sinval Faria. Rio de Janeiro, RJ, Brasil.Background: Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. Methods: The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). Results: Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina (70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. Conclusions: This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil.CryptococcosisMortalityBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/35495/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Soares_Emmanuel_etal_INI_2019.pdfve_Soares_Emmanuel_etal_INI_2019.pdfapplication/pdf1927776https://www.arca.fiocruz.br/bitstream/icict/35495/2/ve_Soares_Emmanuel_etal_INI_2019.pdfdafde8357614b8ed4deb925465145b94MD52TEXTve_Soares_Emmanuel_etal_INI_2019.pdf.txtve_Soares_Emmanuel_etal_INI_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
title Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
spellingShingle Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
Soares, Emmanuel Alves
Cryptococcosis
Mortality
Brazil
title_short Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
title_full Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
title_fullStr Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
title_full_unstemmed Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
title_sort Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study
author Soares, Emmanuel Alves
author_facet Soares, Emmanuel Alves
Lazera, Márcia dos Santos
Wanke, Bodo
Ferreira, Marcela de Faria
Oliveira, Raquel de Vasconcellos Carvalhaes de
Oliveira, Adeno Gonçalves
Coutinho, Ziadir Francisco
author_role author
author2 Lazera, Márcia dos Santos
Wanke, Bodo
Ferreira, Marcela de Faria
Oliveira, Raquel de Vasconcellos Carvalhaes de
Oliveira, Adeno Gonçalves
Coutinho, Ziadir Francisco
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Emmanuel Alves
Lazera, Márcia dos Santos
Wanke, Bodo
Ferreira, Marcela de Faria
Oliveira, Raquel de Vasconcellos Carvalhaes de
Oliveira, Adeno Gonçalves
Coutinho, Ziadir Francisco
dc.subject.en.pt_BR.fl_str_mv Cryptococcosis
Mortality
Brazil
topic Cryptococcosis
Mortality
Brazil
description State Secretary of Health of Piauí. Natan Portela Institute of Tropical Diseases. Departament of infectious disease. Teresina, PI, Brazil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-11T14:04:04Z
dc.date.available.fl_str_mv 2019-09-11T14:04:04Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Emmanuel Alves et al. Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study. Plos Neglected Tropical Diseases, p. 1-17, July 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35495
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007569
dc.identifier.eissn.none.fl_str_mv 1935-2727
identifier_str_mv SOARES, Emmanuel Alves et al. Mortality by cryptococcosis in Brazil from 2000 to 2012: a descriptive epidemiological study. Plos Neglected Tropical Diseases, p. 1-17, July 2019.
1935-2727
10.1371/journal.pntd.0007569
url https://www.arca.fiocruz.br/handle/icict/35495
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35495/1/license.txt
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