ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer

Detalhes bibliográficos
Autor(a) principal: Fonseca, Aline Simoneti
Data de Publicação: 2021
Outros Autores: Ramão, Anelisa, Bürger, Matheus Carvalho, Souza, Jorge Estefano Santana de, Zanette, Dalila Lucíola, Molfetta, Greice Andreotti de, Araújo, Luiza Ferreira de, Bueno, Rafaela de Barros e Lima, Aguiar, Graziela Moura, Plaça, Jessica Rodrigues, Alves, Cleidson de Pádua, Santos, Anemari Ramos Dinarte dos, Vidal, Daniel Onofre, Silva, Gyl Eanes Barros, Panepucci, Rodrigo Alexandre, Peria, Fernanda Maris, Feres, Omar, Rocha, José Joaquim Ribeiro da, Zago, Marco Antonio, Silva Júnior, Wilson Araújo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46942
Resumo: Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil. / Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.
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spelling Fonseca, Aline SimonetiRamão, AnelisaBürger, Matheus CarvalhoSouza, Jorge Estefano Santana deZanette, Dalila LucíolaMolfetta, Greice Andreotti deAraújo, Luiza Ferreira deBueno, Rafaela de Barros e LimaAguiar, Graziela MouraPlaça, Jessica RodriguesAlves, Cleidson de PáduaSantos, Anemari Ramos Dinarte dosVidal, Daniel OnofreSilva, Gyl Eanes BarrosPanepucci, Rodrigo AlexandrePeria, Fernanda MarisFeres, OmarRocha, José Joaquim Ribeiro daZago, Marco AntonioSilva Júnior, Wilson Araújo2021-04-27T19:35:13Z2021-04-27T19:35:13Z2021FONSECA, Aline Simoneti et al. ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer. BMC Cancer, v.21, n. 207, p. 1–14, 2021.1471-2407https://www.arca.fiocruz.br/handle/icict/4694210.1186/s12885-021-07857-xporBMCCâncer ColorretalETV4Colorectal NeoplasmsGenetic MarkersNeoplasias ColorrectalesMarcadores GenéticosAdénocarcinomeAdénomesTumeurs colorectalesMarqueurs génétiquesAdenocarcinomaAdenomaNeoplasias ColorretaisMarcadores GenéticosETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil. / Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Hospital Universitário Presidente Dutra (HUUFMA). Laboratório de Imunofluorescência e Microscopia Eletrônica. São Luís, MA, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia. Ribeirão Preto, SP, Brasil.Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil.Colorectal cancer (CRC) is one of the most common cancers worldwide; it is the fourth leading cause of death in the world and the third in Brazil. Mutations in the APC, DCC, KRAS and TP53 genes have been associated with the progression of sporadic CRC, occurring at defined pathological stages of the tumor progression and consequently modulating several genes in the corresponding signaling pathways. Therefore, the identification of gene signatures that occur at each stage during the CRC progression is critical and can present an impact on the diagnosis and prognosis of the patient. In this study, our main goal was to determine these signatures, by evaluating the gene expression of paired colorectal adenoma and adenocarcinoma samples to identify novel genetic markers in association to the adenoma-adenocarcinoma stage transition. As methods: ten paired adenoma and adenocarcinoma colorectal samples were subjected to microarray gene expression analysis. In addition, mutations in APC, KRAS and TP53 genes were investigated by DNA sequencing in paired samples of adenoma, adenocarcinoma, normal tissue, and peripheral blood from ten patients. In the results, gene expression analysis revealed a signature of 689 differentially expressed genes (DEG) (fold-change> 2, p< 0.05), between the adenoma and adenocarcinoma paired samples analyzed. Gene pathway analysis using the 689 DEG identified important cancer pathways such as remodeling of the extracellular matrix and epithelialmesenchymal transition. Among these DEG, the ETV4 stood out as one of the most expressed in the adenocarcinoma samples, further confirmed in the adenocarcinoma set of samples from the TCGA database. Subsequent in vitro siRNA assays against ETV4 resulted in the decrease of cell proliferation, colony formation and cell migration in the HT29 and SW480 colorectal cell lines. DNA sequencing analysis revealed KRAS and TP53 gene pathogenic mutations, exclusively in the adenocarcinomas samples. This way, our study identified a set of genes with high potential to be used as biomarkers in CRC, with a special emphasis on the ETV4 gene, which demonstrated involvement in proliferation and migration.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL12885_2021_Article_7857ok.pdf12885_2021_Article_7857ok.pdfapplication/pdf1740374https://www.arca.fiocruz.br/bitstream/icict/46942/2/12885_2021_Article_7857ok.pdf61cf7554d39a666dca58fd17f8dd8befMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46942/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXT12885_2021_Article_7857ok.pdf.txt12885_2021_Article_7857ok.pdf.txtExtracted texttext/plain60565https://www.arca.fiocruz.br/bitstream/icict/46942/4/12885_2021_Article_7857ok.pdf.txtb4a0023ae4309b92411d82b121092a35MD54icict/469422021-04-28 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dc.title.pt_BR.fl_str_mv ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
title ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
spellingShingle ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
Fonseca, Aline Simoneti
Câncer Colorretal
ETV4
Colorectal Neoplasms
Genetic Markers
Neoplasias Colorrectales
Marcadores Genéticos
Adénocarcinome
Adénomes
Tumeurs colorectales
Marqueurs génétiques
Adenocarcinoma
Adenoma
Neoplasias Colorretais
Marcadores Genéticos
title_short ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
title_full ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
title_fullStr ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
title_full_unstemmed ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
title_sort ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
author Fonseca, Aline Simoneti
author_facet Fonseca, Aline Simoneti
Ramão, Anelisa
Bürger, Matheus Carvalho
Souza, Jorge Estefano Santana de
Zanette, Dalila Lucíola
Molfetta, Greice Andreotti de
Araújo, Luiza Ferreira de
Bueno, Rafaela de Barros e Lima
Aguiar, Graziela Moura
Plaça, Jessica Rodrigues
Alves, Cleidson de Pádua
Santos, Anemari Ramos Dinarte dos
Vidal, Daniel Onofre
Silva, Gyl Eanes Barros
Panepucci, Rodrigo Alexandre
Peria, Fernanda Maris
Feres, Omar
Rocha, José Joaquim Ribeiro da
Zago, Marco Antonio
Silva Júnior, Wilson Araújo
author_role author
author2 Ramão, Anelisa
Bürger, Matheus Carvalho
Souza, Jorge Estefano Santana de
Zanette, Dalila Lucíola
Molfetta, Greice Andreotti de
Araújo, Luiza Ferreira de
Bueno, Rafaela de Barros e Lima
Aguiar, Graziela Moura
Plaça, Jessica Rodrigues
Alves, Cleidson de Pádua
Santos, Anemari Ramos Dinarte dos
Vidal, Daniel Onofre
Silva, Gyl Eanes Barros
Panepucci, Rodrigo Alexandre
Peria, Fernanda Maris
Feres, Omar
Rocha, José Joaquim Ribeiro da
Zago, Marco Antonio
Silva Júnior, Wilson Araújo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Aline Simoneti
Ramão, Anelisa
Bürger, Matheus Carvalho
Souza, Jorge Estefano Santana de
Zanette, Dalila Lucíola
Molfetta, Greice Andreotti de
Araújo, Luiza Ferreira de
Bueno, Rafaela de Barros e Lima
Aguiar, Graziela Moura
Plaça, Jessica Rodrigues
Alves, Cleidson de Pádua
Santos, Anemari Ramos Dinarte dos
Vidal, Daniel Onofre
Silva, Gyl Eanes Barros
Panepucci, Rodrigo Alexandre
Peria, Fernanda Maris
Feres, Omar
Rocha, José Joaquim Ribeiro da
Zago, Marco Antonio
Silva Júnior, Wilson Araújo
dc.subject.other.pt_BR.fl_str_mv Câncer Colorretal
ETV4
topic Câncer Colorretal
ETV4
Colorectal Neoplasms
Genetic Markers
Neoplasias Colorrectales
Marcadores Genéticos
Adénocarcinome
Adénomes
Tumeurs colorectales
Marqueurs génétiques
Adenocarcinoma
Adenoma
Neoplasias Colorretais
Marcadores Genéticos
dc.subject.en.pt_BR.fl_str_mv Colorectal Neoplasms
Genetic Markers
dc.subject.es.pt_BR.fl_str_mv Neoplasias Colorrectales
Marcadores Genéticos
dc.subject.fr.pt_BR.fl_str_mv Adénocarcinome
Adénomes
Tumeurs colorectales
Marqueurs génétiques
dc.subject.decs.pt_BR.fl_str_mv Adenocarcinoma
Adenoma
Neoplasias Colorretais
Marcadores Genéticos
description Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Genética. Ribeirão Preto, SP, Brasil. / Instituto Nacional de Ciências e Tecnologia em Células Tronco e Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Terapia Celular. Ribeirão Preto, SP, Brasil. / Centro de Biologia de Sistemas Integrativos. Ribeirão Preto, SP, Brasil. / Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-27T19:35:13Z
dc.date.available.fl_str_mv 2021-04-27T19:35:13Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Aline Simoneti et al. ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer. BMC Cancer, v.21, n. 207, p. 1–14, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46942
dc.identifier.issn.pt_BR.fl_str_mv 1471-2407
dc.identifier.doi.none.fl_str_mv 10.1186/s12885-021-07857-x
identifier_str_mv FONSECA, Aline Simoneti et al. ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer. BMC Cancer, v.21, n. 207, p. 1–14, 2021.
1471-2407
10.1186/s12885-021-07857-x
url https://www.arca.fiocruz.br/handle/icict/46942
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
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