Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17831 |
Resumo: | CAPES, CNPq, FINEP, FAPITEC/SE |
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Menezes, Paula dos PassosSantos, Polliana Barbosa Pereira dosDória, Grace Anne AzevedoSousa, Bruna Maria Hipólito deSerafini, Mairim RussoNunes, Paula SantosQuintans Júnior, Lucindo JoséMatos, Iara Lisboa deAlves, Péricles BarretoBezerra, Daniel PereiraMendonça Júnior, Francisco Jaime BezerraSilva, Gabriel Francisco daAquino, Thiago Mendonça deBento, Edson de SouzaScotti, Marcus TulliusScotti, LucianaAraujo, Adriano Antunes de Souza2017-02-16T11:49:12Z2017-02-16T11:49:12Z2017MENEZES, Paula dos Passos et al. Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins. AAPS PharmSciTech, v. 18, n. 1, p. 49-57, 2017.1530-9932https://www.arca.fiocruz.br/handle/icict/1783110.1208/s12249-016-0516-0CAPES, CNPq, FINEP, FAPITEC/SEUniversidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Estadual da Paraíba. Laboratório de Síntese e Vectorização de Moléculas. Campina Grande, PB, Brasil.Universidade Federal de Sergipe. Departamento de Engenharia Química. São Cristóvão, SE, Brasil.Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Laboratório de Ressonância Magnética Nuclear. Maceió, AL, Brasil.Universidade Federal da Paraíba. João Pessoa, PB, Brasil.Universidade Federal da Paraíba. João Pessoa, PB, Brasil.Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.This study evaluated three different methods for the formation of an inclusion complex between alpha- and beta-cyclodextrin (α- and β-CD) and limonene (LIM) with the goal of improving the physicochemical properties of limonene. The study samples were prepared through physical mixing (PM), paste complexation (PC), and slurry complexation (SC) methods in the molar ratio of 1:1 (cyclodextrin:limonene). The complexes prepared were evaluated with thermogravimetry/derivate thermogravimetry, infrared spectroscopy, X-ray diffraction, complexation efficiency through gas chromatography/mass spectrometry analyses, molecular modeling, and nuclear magnetic resonance. The results showed that the physical mixing procedure did not produce complexation, but the paste and slurry methods produced inclusion complexes, which demonstrated interactions outside of the cavity of the CDs. However, the paste obtained with β-cyclodextrin did not demonstrate complexation in the gas chromatographic technique because, after extraction, most of the limonene was either surface-adsorbed by β-cyclodextrin or volatilized during the procedure. We conclude that paste complexation and slurry complexation are effective and economic methods to improve the physicochemical character of limonene and could have important applications in pharmacological activities in terms of an increase in solubility.engAAPSCiclodextrinaComplexo de inclusãoLimonenoMonoterpenoCyclodextrinInclusion complexLimoneneMonoterpeneLimoneno HidroxilasesMolecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17831/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALva_Paula_ Menezes_etal_CPqGM_2016.pdfva_Paula_ 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| dc.title.pt_BR.fl_str_mv |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| title |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| spellingShingle |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins Menezes, Paula dos Passos Ciclodextrina Complexo de inclusão Limoneno Monoterpeno Cyclodextrin Inclusion complex Limonene Monoterpene Limoneno Hidroxilases |
| title_short |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| title_full |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| title_fullStr |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| title_full_unstemmed |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| title_sort |
Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins |
| author |
Menezes, Paula dos Passos |
| author_facet |
Menezes, Paula dos Passos Santos, Polliana Barbosa Pereira dos Dória, Grace Anne Azevedo Sousa, Bruna Maria Hipólito de Serafini, Mairim Russo Nunes, Paula Santos Quintans Júnior, Lucindo José Matos, Iara Lisboa de Alves, Péricles Barreto Bezerra, Daniel Pereira Mendonça Júnior, Francisco Jaime Bezerra Silva, Gabriel Francisco da Aquino, Thiago Mendonça de Bento, Edson de Souza Scotti, Marcus Tullius Scotti, Luciana Araujo, Adriano Antunes de Souza |
| author_role |
author |
| author2 |
Santos, Polliana Barbosa Pereira dos Dória, Grace Anne Azevedo Sousa, Bruna Maria Hipólito de Serafini, Mairim Russo Nunes, Paula Santos Quintans Júnior, Lucindo José Matos, Iara Lisboa de Alves, Péricles Barreto Bezerra, Daniel Pereira Mendonça Júnior, Francisco Jaime Bezerra Silva, Gabriel Francisco da Aquino, Thiago Mendonça de Bento, Edson de Souza Scotti, Marcus Tullius Scotti, Luciana Araujo, Adriano Antunes de Souza |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Menezes, Paula dos Passos Santos, Polliana Barbosa Pereira dos Dória, Grace Anne Azevedo Sousa, Bruna Maria Hipólito de Serafini, Mairim Russo Nunes, Paula Santos Quintans Júnior, Lucindo José Matos, Iara Lisboa de Alves, Péricles Barreto Bezerra, Daniel Pereira Mendonça Júnior, Francisco Jaime Bezerra Silva, Gabriel Francisco da Aquino, Thiago Mendonça de Bento, Edson de Souza Scotti, Marcus Tullius Scotti, Luciana Araujo, Adriano Antunes de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Ciclodextrina Complexo de inclusão Limoneno Monoterpeno |
| topic |
Ciclodextrina Complexo de inclusão Limoneno Monoterpeno Cyclodextrin Inclusion complex Limonene Monoterpene Limoneno Hidroxilases |
| dc.subject.en.pt_BR.fl_str_mv |
Cyclodextrin Inclusion complex Limonene Monoterpene |
| dc.subject.decs.pt_BR.fl_str_mv |
Limoneno Hidroxilases |
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CAPES, CNPq, FINEP, FAPITEC/SE |
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2017 |
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2017-02-16T11:49:12Z |
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2017-02-16T11:49:12Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
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MENEZES, Paula dos Passos et al. Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins. AAPS PharmSciTech, v. 18, n. 1, p. 49-57, 2017. |
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https://www.arca.fiocruz.br/handle/icict/17831 |
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1530-9932 |
| dc.identifier.doi.none.fl_str_mv |
10.1208/s12249-016-0516-0 |
| identifier_str_mv |
MENEZES, Paula dos Passos et al. Molecular modeling and physicochemical properties of supramolecular complexes of limonene with α- and β-Cyclodextrins. AAPS PharmSciTech, v. 18, n. 1, p. 49-57, 2017. 1530-9932 10.1208/s12249-016-0516-0 |
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AAPS |
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