Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50789 |
Resumo: | Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda. Kigali, Rwanda / Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health. Kigali, Rwanda / Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium. |
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Butera, YvanMukantwari, EnathaArtesi, MariaUmuringa, Jeanne d´arcO`Toole, Áine NiamhHill, VerityRooke, StefanHong, Samuel LeandroDellicou, SimonMajyambere, OnesphoreBontems, SebastienBoujemla, BouchraQuick, JoshResende, Paola CristinaLoman, NIckUmumararungu, EsperanceKabanda, AliceMurindahabi, Marylin MilumbuTuyisenge, PatrickGashegu, MisbahRwabihama, Jean PaulSindayiheba, ReubenGikic, DjordjeSouopgui, JacobNdifon, WilfredRutayisire, RobertGatare, SwaibuMpunga, TharcisseNgamije, DanielBours, VincentRambaut, AndrewNsanzimana, SabinBaele, GuyDurkin, KeithMutesa, LeonRujeni, Nadine2022-01-17T18:47:33Z2022-01-17T18:47:33Z2021BUTERA, Yvan et al. Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity. Nature Communications, v. 12, 5705, p. 1-11, 2021.2041-1723https://www.arca.fiocruz.br/handle/icict/5078910.1038/s41467-021-25985-7engNatureSARS-CoV-2Sequenciamento genômicoRuanda, ÁfricaImportância dos viajantesCom diversidade de linhagemTaxas de transmissãoSARS-CoV-2RwandaGenomic sequencingImportance of incoming travelersLineage diversityTransmission ratesGenomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCenter for Human Genetics, College of Medicine and Health Sciences, University of Rwanda. Kigali, Rwanda / Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health. Kigali, Rwanda / Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium.National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.Laboratory of Human Genetics, GIGA Research Institute. Liège, Belgium.National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.Institute of Evolutionary Biology, University of Edinburgh. Edinburgh, Scotland.Institute of Evolutionary Biology, University of Edinburgh. Edinburgh, Scotland.Institute of Evolutionary Biology, University of Edinburgh. Edinburgh, Scotland.Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven. Leuven, Belgium.Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven. Leuven, Belgium / Spatial Epidemiology Laboratory, Université Libre de Bruxelles. Brussels, Belgium.National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.Department of Clinical Microbiology, University Hospital of Liège., Liège, Belgium.Laboratory of Human Genetics, GIGA Research Institute. Liège, Belgium.University of Birmingham. Birmingham, England.University College London. London, England / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.University of Birmingham. Birmingham, England.National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda.National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / School of Science, College of Science and Technology, University of Rwanda. Kigali, Rwanda.National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda / Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Université Libre de, Bruxelles. Gosselies, Belgium.African Institute for Mathematical Sciences. Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / National Reference Laboratory, Rwanda Biomedical Center. Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, RwandaRwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, RwandaLaboratory of Human Genetics, GIGA Research Institute, Liège, Belgium / Department of Human Genetics, University Hospital of Liège, Liège, Belgium.Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health. Kigali, Rwanda.Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven. Leuven, Belgium.Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium.Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda / Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda / Department of Microbiology, Immunology and Transplantation, Rega Institute KU Leuven, Leuven, Belgium.COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2. Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from strains circulating in Rwanda from May 2020 to February 2021. In particular, we report a shift in variant distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore, we report the detection of the first Rwandan cases of the B.1.1.7 and B.1.351 variants of concern among incoming travelers tested at Kigali International Airport. To assess the importance of viral introductions from neighboring countries and local transmission, we exploit available individual travel history metadata to inform spatio-temporal phylogeographic inference, enabling us to take into account infections from unsampled locations. We uncover an important role of neighboring countries in seeding introductions into Rwanda, including those from which no genomic sequences were available. Our results highlight the importance of systematic genomic surveillance and regional collaborations for a durable response towards combating COVID-19.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50789/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL5 - Butera_Yvan_etal_IOC_COVID-19_2021.pdf5 - Butera_Yvan_etal_IOC_COVID-19_2021.pdfapplication/pdf9682975https://www.arca.fiocruz.br/bitstream/icict/50789/2/5%20-%20Butera_Yvan_etal_IOC_COVID-19_2021.pdf7e4e3941eba9f80df45d97edd9f3987fMD52icict/507892022-01-17 21:34:21.432oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-01-18T00:34:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| title |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| spellingShingle |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity Butera, Yvan SARS-CoV-2 Sequenciamento genômico Ruanda, África Importância dos viajantes Com diversidade de linhagem Taxas de transmissão SARS-CoV-2 Rwanda Genomic sequencing Importance of incoming travelers Lineage diversity Transmission rates |
| title_short |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| title_full |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| title_fullStr |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| title_full_unstemmed |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| title_sort |
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity |
| author |
Butera, Yvan |
| author_facet |
Butera, Yvan Mukantwari, Enatha Artesi, Maria Umuringa, Jeanne d´arc O`Toole, Áine Niamh Hill, Verity Rooke, Stefan Hong, Samuel Leandro Dellicou, Simon Majyambere, Onesphore Bontems, Sebastien Boujemla, Bouchra Quick, Josh Resende, Paola Cristina Loman, NIck Umumararungu, Esperance Kabanda, Alice Murindahabi, Marylin Milumbu Tuyisenge, Patrick Gashegu, Misbah Rwabihama, Jean Paul Sindayiheba, Reuben Gikic, Djordje Souopgui, Jacob Ndifon, Wilfred Rutayisire, Robert Gatare, Swaibu Mpunga, Tharcisse Ngamije, Daniel Bours, Vincent Rambaut, Andrew Nsanzimana, Sabin Baele, Guy Durkin, Keith Mutesa, Leon Rujeni, Nadine |
| author_role |
author |
| author2 |
Mukantwari, Enatha Artesi, Maria Umuringa, Jeanne d´arc O`Toole, Áine Niamh Hill, Verity Rooke, Stefan Hong, Samuel Leandro Dellicou, Simon Majyambere, Onesphore Bontems, Sebastien Boujemla, Bouchra Quick, Josh Resende, Paola Cristina Loman, NIck Umumararungu, Esperance Kabanda, Alice Murindahabi, Marylin Milumbu Tuyisenge, Patrick Gashegu, Misbah Rwabihama, Jean Paul Sindayiheba, Reuben Gikic, Djordje Souopgui, Jacob Ndifon, Wilfred Rutayisire, Robert Gatare, Swaibu Mpunga, Tharcisse Ngamije, Daniel Bours, Vincent Rambaut, Andrew Nsanzimana, Sabin Baele, Guy Durkin, Keith Mutesa, Leon Rujeni, Nadine |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Butera, Yvan Mukantwari, Enatha Artesi, Maria Umuringa, Jeanne d´arc O`Toole, Áine Niamh Hill, Verity Rooke, Stefan Hong, Samuel Leandro Dellicou, Simon Majyambere, Onesphore Bontems, Sebastien Boujemla, Bouchra Quick, Josh Resende, Paola Cristina Loman, NIck Umumararungu, Esperance Kabanda, Alice Murindahabi, Marylin Milumbu Tuyisenge, Patrick Gashegu, Misbah Rwabihama, Jean Paul Sindayiheba, Reuben Gikic, Djordje Souopgui, Jacob Ndifon, Wilfred Rutayisire, Robert Gatare, Swaibu Mpunga, Tharcisse Ngamije, Daniel Bours, Vincent Rambaut, Andrew Nsanzimana, Sabin Baele, Guy Durkin, Keith Mutesa, Leon Rujeni, Nadine |
| dc.subject.other.pt_BR.fl_str_mv |
SARS-CoV-2 Sequenciamento genômico Ruanda, África Importância dos viajantes Com diversidade de linhagem Taxas de transmissão |
| topic |
SARS-CoV-2 Sequenciamento genômico Ruanda, África Importância dos viajantes Com diversidade de linhagem Taxas de transmissão SARS-CoV-2 Rwanda Genomic sequencing Importance of incoming travelers Lineage diversity Transmission rates |
| dc.subject.en.pt_BR.fl_str_mv |
SARS-CoV-2 Rwanda Genomic sequencing Importance of incoming travelers Lineage diversity Transmission rates |
| description |
Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda. Kigali, Rwanda / Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health. Kigali, Rwanda / Laboratory of Human Genetics, GIGA Research Institute, Liège, Belgium. |
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2021 |
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2021 |
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2022-01-17T18:47:33Z |
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2022-01-17T18:47:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BUTERA, Yvan et al. Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity. Nature Communications, v. 12, 5705, p. 1-11, 2021. |
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https://www.arca.fiocruz.br/handle/icict/50789 |
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2041-1723 |
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10.1038/s41467-021-25985-7 |
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BUTERA, Yvan et al. Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity. Nature Communications, v. 12, 5705, p. 1-11, 2021. 2041-1723 10.1038/s41467-021-25985-7 |
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Nature |
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