Statins Increase Rifampin Mycobactericidal Effect
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10976 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
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Lobato, Lívia SilvaRosa, Patrícia SammarcoFerreira, Jessica da SilvaNeumann, Arthur da SilvaSilva, Marlei Gomes daNascimento, Dejair Caitano doSoares, Cleverson TeixeiraPedrini, Silvia Cristina BarbosaOliveira, Diego Sá Leal deMonteiro, Cláudia PeresPereira, Geraldo Moura BatistaAlves, Marcelo RibeiroHacker, Mariana AndreaMoraes, Milton OzórioPessolani, Maria Cristina VidalDuarte, Rafael SilvaLara, Flávio Alves2015-06-26T13:04:35Z2015-06-26T13:04:35Z2014LOBATO, Lívia Silva et al. Statins Increase Rifampin Mycobactericidal Effect. Antimicrobial Agents and Chemotherapy, v.58, n.10, p.5766-5774, oct. 2014.https://www.arca.fiocruz.br/handle/icict/1097610.1128/AAC.01826-13engAmerican Society for MicrobiologyStatins Increase Rifampin Mycobactericidal Effectinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Microbactérias. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil.Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chgas. Centro de Pesquisa Clínica em HIV/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.niversidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Microbactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Mycobacterium leprae and Mycobacterium tuberculosis antimicrobial resistance has been followed with great concern during the last years, while the need for new drugs able to control leprosy and tuberculosis, mainly due to extensively drug-resistant tuberculosis (XDR-TB), is pressing. Our group recently showed that M. leprae is able to induce lipid body biogenesis and cholesterol accumulation in macrophages and Schwann cells, facilitating its viability and replication. Considering these previous results, we investigated the efficacies of two statins on the intracellular viability of mycobacteria within the macrophage, as well as the effect of atorvastatin on M. leprae infections in BALB/c mice. We observed that intracellular mycobacteria viability decreased markedly after incubation with both statins, but atorvastatin showed the best inhibitory effect when combined with rifampin. Using Shepard’s model, we observed with atorvastatin an efficacy in controlling M. leprae and inflammatory infiltrate in the BALB/c footpad, in a serum cholesterol level-dependent way. We conclude that statins contribute to macrophage-bactericidal activity against Mycobacterium bovis, M. leprae, and M. tuberculosis. It is likely that the association of statins with the actual multidrug therapy effectively reduces mycobacterial viability and tissue lesion in leprosy and tuberculosis patients, although epidemiological studies are still needed for confirmation.Mycobacterium lepraeMycobacterium tuberculosisTuberculosisLeprosyStatinsIntracellular mycobacterialRifampinRifampinaInibidores de Hidroximetilglutaril-CoA RedutasesTuberculoseMycobacterium lepraeMycobacterium tuberculosisHanseníaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10976/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALlivia_lobatoetal_IOC_2014.pdfapplication/pdf2385322https://www.arca.fiocruz.br/bitstream/icict/10976/2/livia_lobatoetal_IOC_2014.pdf5679c7e513bc97c5728fa40d92b3b46bMD52TEXTlivia_lobatoetal_IOC_2014.pdf.txtlivia_lobatoetal_IOC_2014.pdf.txtExtracted texttext/plain52440https://www.arca.fiocruz.br/bitstream/icict/10976/3/livia_lobatoetal_IOC_2014.pdf.txtc9eff0973fca65d448d4b10444089b47MD53icict/109762022-06-24 12:19:37.071oai:www.arca.fiocruz.br:icict/10976TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:19:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Statins Increase Rifampin Mycobactericidal Effect |
| title |
Statins Increase Rifampin Mycobactericidal Effect |
| spellingShingle |
Statins Increase Rifampin Mycobactericidal Effect Lobato, Lívia Silva Mycobacterium leprae Mycobacterium tuberculosis Tuberculosis Leprosy Statins Intracellular mycobacterial Rifampin Rifampina Inibidores de Hidroximetilglutaril-CoA Redutases Tuberculose Mycobacterium leprae Mycobacterium tuberculosis Hanseníase |
| title_short |
Statins Increase Rifampin Mycobactericidal Effect |
| title_full |
Statins Increase Rifampin Mycobactericidal Effect |
| title_fullStr |
Statins Increase Rifampin Mycobactericidal Effect |
| title_full_unstemmed |
Statins Increase Rifampin Mycobactericidal Effect |
| title_sort |
Statins Increase Rifampin Mycobactericidal Effect |
| author |
Lobato, Lívia Silva |
| author_facet |
Lobato, Lívia Silva Rosa, Patrícia Sammarco Ferreira, Jessica da Silva Neumann, Arthur da Silva Silva, Marlei Gomes da Nascimento, Dejair Caitano do Soares, Cleverson Teixeira Pedrini, Silvia Cristina Barbosa Oliveira, Diego Sá Leal de Monteiro, Cláudia Peres Pereira, Geraldo Moura Batista Alves, Marcelo Ribeiro Hacker, Mariana Andrea Moraes, Milton Ozório Pessolani, Maria Cristina Vidal Duarte, Rafael Silva Lara, Flávio Alves |
| author_role |
author |
| author2 |
Rosa, Patrícia Sammarco Ferreira, Jessica da Silva Neumann, Arthur da Silva Silva, Marlei Gomes da Nascimento, Dejair Caitano do Soares, Cleverson Teixeira Pedrini, Silvia Cristina Barbosa Oliveira, Diego Sá Leal de Monteiro, Cláudia Peres Pereira, Geraldo Moura Batista Alves, Marcelo Ribeiro Hacker, Mariana Andrea Moraes, Milton Ozório Pessolani, Maria Cristina Vidal Duarte, Rafael Silva Lara, Flávio Alves |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lobato, Lívia Silva Rosa, Patrícia Sammarco Ferreira, Jessica da Silva Neumann, Arthur da Silva Silva, Marlei Gomes da Nascimento, Dejair Caitano do Soares, Cleverson Teixeira Pedrini, Silvia Cristina Barbosa Oliveira, Diego Sá Leal de Monteiro, Cláudia Peres Pereira, Geraldo Moura Batista Alves, Marcelo Ribeiro Hacker, Mariana Andrea Moraes, Milton Ozório Pessolani, Maria Cristina Vidal Duarte, Rafael Silva Lara, Flávio Alves |
| dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium leprae Mycobacterium tuberculosis Tuberculosis Leprosy Statins Intracellular mycobacterial Rifampin |
| topic |
Mycobacterium leprae Mycobacterium tuberculosis Tuberculosis Leprosy Statins Intracellular mycobacterial Rifampin Rifampina Inibidores de Hidroximetilglutaril-CoA Redutases Tuberculose Mycobacterium leprae Mycobacterium tuberculosis Hanseníase |
| dc.subject.decs.pt_BR.fl_str_mv |
Rifampina Inibidores de Hidroximetilglutaril-CoA Redutases Tuberculose Mycobacterium leprae Mycobacterium tuberculosis Hanseníase |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2015-06-26T13:04:35Z |
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2015-06-26T13:04:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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LOBATO, Lívia Silva et al. Statins Increase Rifampin Mycobactericidal Effect. Antimicrobial Agents and Chemotherapy, v.58, n.10, p.5766-5774, oct. 2014. |
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https://www.arca.fiocruz.br/handle/icict/10976 |
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10.1128/AAC.01826-13 |
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LOBATO, Lívia Silva et al. Statins Increase Rifampin Mycobactericidal Effect. Antimicrobial Agents and Chemotherapy, v.58, n.10, p.5766-5774, oct. 2014. 10.1128/AAC.01826-13 |
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American Society for Microbiology |
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American Society for Microbiology |
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