Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil

Detalhes bibliográficos
Autor(a) principal: Mejía, Matilde del Carmen Contreras
Data de Publicação: 2014
Outros Autores: Santos, Maisa Porto dos, Silva, George Allan Villarouco da, Passos, Isabella da Motta, Naveca, Felipe Gomes, Cunha, Maria da Graça Souza, Moraes, Milton Ozório, Paula, Lucia de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11932
Resumo: Universidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil.
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spelling Mejía, Matilde del Carmen ContrerasSantos, Maisa Porto dosSilva, George Allan Villarouco daPassos, Isabella da MottaNaveca, Felipe GomesCunha, Maria da Graça SouzaMoraes, Milton OzórioPaula, Lucia de2015-10-13T00:30:46Z2015-10-13T00:30:46Z20141098-660Xhttps://www.arca.fiocruz.br/handle/icict/1193210.1128/JCM.01688-14engAmerican Society for MicrobiologyPacientesMycobacterium lepraeLeprosy PatientsAmazonas StateDrug ResistanceRifampinMycobacterium lepraeHanseníaseResistência a MedicamentosRifampinaIdentification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil.Universidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil / Instituto Nacional de Pesquisa da Amazônia-INPA. Laboratório de Micobacteriologia. Manaus, Am, Brasil.Universidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, Am, Brasil.Universidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil / Universidade Estadual do Amazonas. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, Am, Brasil.Fundação Alfredo da Matta. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil / Universidade Federal de Goiás. Regional Catalão. Departamento de Ciências Biológicas. Catalão, GO, Brasil.The aim of this study was to identify polymorphisms in the folp1, gyrA, and rpoB genes in leprosy patients treated in Amazonas State, Brazil. Among 197 slit-skin smear samples from untreated or relapsed patients, we found three cases of primary resistance to rifampin and one confirmed case of multidrug resistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11932/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALmilton_moraes2_etal_IOC_2014.pdfmilton_moraes2_etal_IOC_2014.pdfapplication/pdf115426https://www.arca.fiocruz.br/bitstream/icict/11932/2/milton_moraes2_etal_IOC_2014.pdf1f276af60fd094b34d8f66e20b70dbdcMD52TEXTmilton_moraes2_etal_IOC_2014.pdf.txtmilton_moraes2_etal_IOC_2014.pdf.txtExtracted texttext/plain13592https://www.arca.fiocruz.br/bitstream/icict/11932/3/milton_moraes2_etal_IOC_2014.pdf.txt758ef5719248aa62d51f0ee27ec8620cMD53icict/119322023-09-05 10:25:59.907oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:25:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
title Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
spellingShingle Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
Mejía, Matilde del Carmen Contreras
Pacientes
Mycobacterium leprae
Leprosy Patients
Amazonas State
Drug Resistance
Rifampin
Mycobacterium leprae
Hanseníase
Resistência a Medicamentos
Rifampina
title_short Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
title_full Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
title_fullStr Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
title_full_unstemmed Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
title_sort Identification of Primary Drug Resistance to Rifampin in Mycobacterium leprae Strains from Leprosy Patients in Amazonas State, Brazil
author Mejía, Matilde del Carmen Contreras
author_facet Mejía, Matilde del Carmen Contreras
Santos, Maisa Porto dos
Silva, George Allan Villarouco da
Passos, Isabella da Motta
Naveca, Felipe Gomes
Cunha, Maria da Graça Souza
Moraes, Milton Ozório
Paula, Lucia de
author_role author
author2 Santos, Maisa Porto dos
Silva, George Allan Villarouco da
Passos, Isabella da Motta
Naveca, Felipe Gomes
Cunha, Maria da Graça Souza
Moraes, Milton Ozório
Paula, Lucia de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mejía, Matilde del Carmen Contreras
Santos, Maisa Porto dos
Silva, George Allan Villarouco da
Passos, Isabella da Motta
Naveca, Felipe Gomes
Cunha, Maria da Graça Souza
Moraes, Milton Ozório
Paula, Lucia de
dc.subject.other.pt_BR.fl_str_mv Pacientes
topic Pacientes
Mycobacterium leprae
Leprosy Patients
Amazonas State
Drug Resistance
Rifampin
Mycobacterium leprae
Hanseníase
Resistência a Medicamentos
Rifampina
dc.subject.en.pt_BR.fl_str_mv Mycobacterium leprae
Leprosy Patients
Amazonas State
Drug Resistance
Rifampin
dc.subject.decs.pt_BR.fl_str_mv Mycobacterium leprae
Hanseníase
Resistência a Medicamentos
Rifampina
description Universidade Federal do Amazonas. Programa de Pós-graduação em Imunologia Básica e Aplicada. Manaus, Am, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-10-13T00:30:46Z
dc.date.available.fl_str_mv 2015-10-13T00:30:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11932
dc.identifier.issn.none.fl_str_mv 1098-660X
dc.identifier.doi.none.fl_str_mv 10.1128/JCM.01688-14
identifier_str_mv 1098-660X
10.1128/JCM.01688-14
url https://www.arca.fiocruz.br/handle/icict/11932
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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