Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children

Detalhes bibliográficos
Autor(a) principal: Wakimoto, Mayumi Duarte
Data de Publicação: 2018
Outros Autores: Camacho, Luiz Antonio Bastos, Gonin, Michelle Luiza, Brasil, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31730
Resumo: 2020-01-31
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spelling Wakimoto, Mayumi DuarteCamacho, Luiz Antonio BastosGonin, Michelle LuizaBrasil, Patrícia2019-02-19T11:46:49Z2019-02-19T11:46:49Z2018WAKIMOTO, Mayumi Duarte et al. Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children. Journal of Tropical Pediatrics, v. 64, p. 373–381, 2018.0142-6338https://www.arca.fiocruz.br/handle/icict/3173010.1093/tropej/fmx0781465-3664engOxford University PressClinical and laboratory factors associated with severe dengue: a case-control study of hospitalized childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-31Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Secretaria Municipal de Saúde e Defesa Civil do Rio de Janeiro. Hospital Municipal Jesus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: More than half of the hospitalizations because of dengue in Brazil occurred in children <15 years of age in 2007 and 2008, an unexpected change in the epidemiological pattern. We sought to determine clinical and laboratory parameters associated with severity. Methods: A case-control study was conducted in three pediatric hospitals in Rio de Janeiro, Brazil; 233 laboratory-confirmed dengue patients were included: 69 cases and 164 controls. Specific clinical and laboratory factors were assessed using univariate and multivariate logistic regression models. Results: Lethargy [adjusted odds ratio (ORa): 9.15, 95% confidence interval (CI): 3.08–27.12], dyspnea (ORa: 8.24, 95% CI: 3.27–20.72) and abdominal pain (ORa: 6.78, 95% CI: 1.44–31.84) were independently associated with severe dengue in children. Lethargy and dyspnea presented as early as 72 and 48 h, respectively, before shock. Conclusions: Abdominal pain and lethargy confirmed their role as warning signs, which along with dyspnea might be helpful in identifying cases progressing to severe dengue.Case-control studiesDenguePediatricsSevere dengueShockinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31730/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Wakimoto_Mayumi_etal_INI_2018.pdfve_Wakimoto_Mayumi_etal_INI_2018.pdfapplication/pdf222314https://www.arca.fiocruz.br/bitstream/icict/31730/2/ve_Wakimoto_Mayumi_etal_INI_2018.pdf9fd60e52ff43a822c5d4d63cb34c318eMD52TEXTve_Wakimoto_Mayumi_etal_INI_2018.pdf.txtve_Wakimoto_Mayumi_etal_INI_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
title Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
spellingShingle Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
Wakimoto, Mayumi Duarte
Case-control studies
Dengue
Pediatrics
Severe dengue
Shock
title_short Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
title_full Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
title_fullStr Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
title_full_unstemmed Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
title_sort Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children
author Wakimoto, Mayumi Duarte
author_facet Wakimoto, Mayumi Duarte
Camacho, Luiz Antonio Bastos
Gonin, Michelle Luiza
Brasil, Patrícia
author_role author
author2 Camacho, Luiz Antonio Bastos
Gonin, Michelle Luiza
Brasil, Patrícia
author2_role author
author
author
dc.contributor.author.fl_str_mv Wakimoto, Mayumi Duarte
Camacho, Luiz Antonio Bastos
Gonin, Michelle Luiza
Brasil, Patrícia
dc.subject.en.pt_BR.fl_str_mv Case-control studies
Dengue
Pediatrics
Severe dengue
Shock
topic Case-control studies
Dengue
Pediatrics
Severe dengue
Shock
description 2020-01-31
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-19T11:46:49Z
dc.date.available.fl_str_mv 2019-02-19T11:46:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WAKIMOTO, Mayumi Duarte et al. Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children. Journal of Tropical Pediatrics, v. 64, p. 373–381, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31730
dc.identifier.issn.pt_BR.fl_str_mv 0142-6338
dc.identifier.doi.none.fl_str_mv 10.1093/tropej/fmx078
dc.identifier.eissn.none.fl_str_mv 1465-3664
identifier_str_mv WAKIMOTO, Mayumi Duarte et al. Clinical and laboratory factors associated with severe dengue: a case-control study of hospitalized children. Journal of Tropical Pediatrics, v. 64, p. 373–381, 2018.
0142-6338
10.1093/tropej/fmx078
1465-3664
url https://www.arca.fiocruz.br/handle/icict/31730
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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