Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy

Detalhes bibliográficos
Autor(a) principal: Santi, Ana Maria Murta
Data de Publicação: 2022
Outros Autores: Murta, Silvane Maria Fonseca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56023
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil.
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spelling Santi, Ana Maria MurtaMurta, Silvane Maria Fonseca2022-12-16T17:20:26Z2022-12-16T17:20:26Z2022SANTI, Ana Maria Murta; MURTA, Silvane Maria Fonseca. Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e210401, p. 1-7, 2022.0074-0276https://www.arca.fiocruz.br/handle/icict/5602310.1590/0074-02760210401engFiocruz/IOCAntioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil.Chagas disease and leishmaniasis are neglected tropical diseases caused by the protozoan parasites Trypanosoma cruzi and Leishmania spp., respectively. They are among the most important parasitic diseases, affecting millions of people worldwide, being a considerable global challenge. However, there is no human vaccine available against T. cruzi and Leishmania infections, and their control is based mainly on chemotherapy. Treatments for Chagas disease and leishmaniasis have multiple limitations, mainly due to the high toxicity of the available drugs, long-term treatment protocols, and the occurrence of drug-resistant parasite strains. In the case of Chagas disease, there is still the problem of low cure rates in the chronic stage of the disease. Therefore, new therapeutic agents and novel targets for drug development are urgently needed. Antioxidant defence in Trypanosomatidae is a potential target for chemotherapy because the organisms present a unique mechanism for trypanothione-dependent detoxification of peroxides, which differs from that found in vertebrates. Cellular thiol redox homeostasis is maintained by the biosynthesis and reduction of trypanothione, involving different enzymes that act in concert. This study provides an overview of the antioxidant defence focusing on iron superoxide dismutase A, tryparedoxin peroxidase, and ascorbate peroxidase and how the enzymes play an important role in the defence against oxidative stress and their involvement in drug resistance mechanisms in T. cruzi and Leishmania spp.Trypanosoma cruziLeishmania sppChemotherapyAntioxidant defenceDrug resistanceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56023/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAntioxidant defence system as a rational target.pdfAntioxidant defence system as a rational target.pdfapplication/pdf6338517https://www.arca.fiocruz.br/bitstream/icict/56023/2/Antioxidant%20defence%20system%20as%20a%20rational%20target.pdf9c16fb4dd9c393468ffd7cef11186306MD52icict/560232023-04-30 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dc.title.en_US.fl_str_mv Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
title Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
spellingShingle Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
Santi, Ana Maria Murta
Trypanosoma cruzi
Leishmania spp
Chemotherapy
Antioxidant defence
Drug resistance
title_short Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
title_full Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
title_fullStr Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
title_full_unstemmed Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
title_sort Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy
author Santi, Ana Maria Murta
author_facet Santi, Ana Maria Murta
Murta, Silvane Maria Fonseca
author_role author
author2 Murta, Silvane Maria Fonseca
author2_role author
dc.contributor.author.fl_str_mv Santi, Ana Maria Murta
Murta, Silvane Maria Fonseca
dc.subject.en.en_US.fl_str_mv Trypanosoma cruzi
Leishmania spp
Chemotherapy
Antioxidant defence
Drug resistance
topic Trypanosoma cruzi
Leishmania spp
Chemotherapy
Antioxidant defence
Drug resistance
description Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-16T17:20:26Z
dc.date.available.fl_str_mv 2022-12-16T17:20:26Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTI, Ana Maria Murta; MURTA, Silvane Maria Fonseca. Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e210401, p. 1-7, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56023
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760210401
identifier_str_mv SANTI, Ana Maria Murta; MURTA, Silvane Maria Fonseca. Antioxidant defence system as a rational target for Chagas disease and Leishmaniasis chemotherapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e210401, p. 1-7, 2022.
0074-0276
10.1590/0074-02760210401
url https://www.arca.fiocruz.br/handle/icict/56023
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56023/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56023/2/Antioxidant%20defence%20system%20as%20a%20rational%20target.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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