Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death

Detalhes bibliográficos
Autor(a) principal: Silva, Janaína Carla da
Data de Publicação: 2022
Outros Autores: Scandolara, Thalita Basso, Kern, Rodrigo, Jaques, Hellen dos Santos, Malanowski, Jessica, Alves, Fernanda Mara, Rech, Daniel, Silveira, Guilherme Ferreira, Panis, Carolina
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56434
Resumo: Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.
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spelling Silva, Janaína Carla daScandolara, Thalita BassoKern, RodrigoJaques, Hellen dos SantosMalanowski, JessicaAlves, Fernanda MaraRech, DanielSilveira, Guilherme FerreiraPanis, Carolina2023-01-10T20:12:37Z2023-01-10T20:12:37Z2022SILVA, Janaína Carla da et al. Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death. Cancers., v. 14, n. 5199, p. 1–15 , 2022.1097-0142https://www.arca.fiocruz.br/handle/icict/5643410.3390/ cancers14215199porMDPIOccupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and deathinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil. / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil. / Hospital do Câncer de Francisco Beltrão. Francisco Beltrão, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.Breast cancer risk stratification is a strategy based using on clinical parameters to predict patients’ risk of recurrence or death, categorized as low, intermediate, or high risk. Both low and high risk are based on well-defined clinical parameters. However, the intermediate risk depends on more malleable parameters. It means an increased possibility for either suboptimal treatment, leading to disease recurrence, or systemic damage due to drug overload toxicity. Therefore, identifying new factors that help to characterize better the intermediate-risk stratification, such as environmental exposures, is necessary. For this purpose, we evaluated the impact of occupational exposure to pesticides on the systemic profile of cytokines (IL-12, IL-4, IL-17A, and TNF-α) and oxidative stress (hydroperoxides, total antioxidants, and nitric oxide metabolites), as well as TGF-β1, CTLA-4, CD8, and CD4 expression, investigated in tumor cells. Occupational exposure to pesticides decreased the levels of IL-12 and significantly increased the expression of TGF-β1 and CTLA-4 in the immune infiltrate. Nevertheless, we observed a decrease in CTLA-4 in tumor samples and CD8 in infiltrating cells of intermediate overweight or obese patients with at least one metastatic lymph node at the diagnosis. These findings indicate that occupational exposure to pesticides changes the molecular behavior of disease and should be considered for intermediate-risk stratification assessment in breast cancer patients.Breast NeoplasmsCytokinesOxidative StressInflammationPesticide ExposureNeoplasias de la MamaEstrés OxidativoInflamaciónExposición a PlaguicidasTumeurs du seinStress oxydatifExposition Aux PesticidesNeoplasias da MamaCitocinasEstresse OxidativoInflamaçãoExposição a Praguicidasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALcancers-14-05199-v2ok.pdfcancers-14-05199-v2ok.pdfapplication/pdf1872099https://www.arca.fiocruz.br/bitstream/icict/56434/2/cancers-14-05199-v2ok.pdf51d729b687af87f368e6595553aa4ad8MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56434/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/564342023-01-10 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dc.title.en_US.fl_str_mv Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
title Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
spellingShingle Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
Silva, Janaína Carla da
Breast Neoplasms
Cytokines
Oxidative Stress
Inflammation
Pesticide Exposure
Neoplasias de la Mama
Estrés Oxidativo
Inflamación
Exposición a Plaguicidas
Tumeurs du sein
Stress oxydatif
Exposition Aux Pesticides
Neoplasias da Mama
Citocinas
Estresse Oxidativo
Inflamação
Exposição a Praguicidas
title_short Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
title_full Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
title_fullStr Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
title_full_unstemmed Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
title_sort Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death
author Silva, Janaína Carla da
author_facet Silva, Janaína Carla da
Scandolara, Thalita Basso
Kern, Rodrigo
Jaques, Hellen dos Santos
Malanowski, Jessica
Alves, Fernanda Mara
Rech, Daniel
Silveira, Guilherme Ferreira
Panis, Carolina
author_role author
author2 Scandolara, Thalita Basso
Kern, Rodrigo
Jaques, Hellen dos Santos
Malanowski, Jessica
Alves, Fernanda Mara
Rech, Daniel
Silveira, Guilherme Ferreira
Panis, Carolina
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Janaína Carla da
Scandolara, Thalita Basso
Kern, Rodrigo
Jaques, Hellen dos Santos
Malanowski, Jessica
Alves, Fernanda Mara
Rech, Daniel
Silveira, Guilherme Ferreira
Panis, Carolina
dc.subject.en.en_US.fl_str_mv Breast Neoplasms
Cytokines
Oxidative Stress
Inflammation
Pesticide Exposure
topic Breast Neoplasms
Cytokines
Oxidative Stress
Inflammation
Pesticide Exposure
Neoplasias de la Mama
Estrés Oxidativo
Inflamación
Exposición a Plaguicidas
Tumeurs du sein
Stress oxydatif
Exposition Aux Pesticides
Neoplasias da Mama
Citocinas
Estresse Oxidativo
Inflamação
Exposição a Praguicidas
dc.subject.es.en_US.fl_str_mv Neoplasias de la Mama
Estrés Oxidativo
Inflamación
Exposición a Plaguicidas
dc.subject.fr.en_US.fl_str_mv Tumeurs du sein
Stress oxydatif
Exposition Aux Pesticides
dc.subject.decs.en_US.fl_str_mv Neoplasias da Mama
Citocinas
Estresse Oxidativo
Inflamação
Exposição a Praguicidas
description Universidade Estadual do Oeste do Paraná. Centro de Ciências da Saúde. Laboratório de Biologia de Tumores. Francisco Beltrão, PR, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-10T20:12:37Z
dc.date.available.fl_str_mv 2023-01-10T20:12:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Janaína Carla da et al. Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death. Cancers., v. 14, n. 5199, p. 1–15 , 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56434
dc.identifier.issn.en_US.fl_str_mv 1097-0142
dc.identifier.doi.none.fl_str_mv 10.3390/ cancers14215199
identifier_str_mv SILVA, Janaína Carla da et al. Occupational exposure to pesticides affects pivotal immunologic anti-tumor responses in breast cancer women from the intermediate risk of recurrence and death. Cancers., v. 14, n. 5199, p. 1–15 , 2022.
1097-0142
10.3390/ cancers14215199
url https://www.arca.fiocruz.br/handle/icict/56434
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56434/2/cancers-14-05199-v2ok.pdf
https://www.arca.fiocruz.br/bitstream/icict/56434/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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