Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28501 |
Resumo: | 2020-01-01 |
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Mourão, Luiza CarvalhoBaptista, Rodrigo de PaulaAlmeida, Zélia Barbosa deGrynberg, PriscilaPucci, Maíra MazzoniGomes, Thiago CastroFontes, Cor Jesus FernandesRathore, SumitSharma, Yagya D.Pereira, Rosiane Aparecida da SilvaBemquerer, Marcelo PortoBraga, Érika Martins2018-08-31T15:40:06Z2018-08-31T15:40:06Z2018MOURÃO, Luiza Carvalho et al. Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia. Scientific Reports, v. 8, e 8767, 20182045-2322https://www.arca.fiocruz.br/handle/icict/2850110.1038/s41598-018-27109-6engNature Publishing GroupP. vivaxmalariaP. vivaxmalariaAnti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilCenter for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Embrapa Recursos Genéticos e Biotecnologia. Brasília, DF, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Universidade Federal do Mato Grosso. Faculdade de Ciências Médicas. Cuiabá, MT, Brazil.Department of Biotechnology. All India Institute of Medical Sciences. New Delhi, India.Department of Biotechnology. All India Institute of Medical Sciences. New Delhi, India.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Embrapa Recursos Genéticos e Biotecnologia. Brasília, DF, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Clearance of non-infected red blood cells (nRBCs) is one of the main components of anemia associated with Plasmodium vivax malaria. Recently, we have shown that anemic patients with P. vivax infection had elevated levels of anti-RBCs antibodies, which could enhance in vitro phagocytosis of nRBCs and decrease their deformability. Using immunoproteomics, here we characterized erythrocytic antigens that are diferentially recognized by autoantibodies from anemic and non-anemic patients with acute vivax malaria. Protein spots exclusively recognized by anemic P. vivax-infected patients were identifed by mass spectrometry revealing band 3 and spectrin as the main targets. To confrm this fnding, antibody responses against these specifc proteins were assessed by ELISA. In addition, an inverse association between hemoglobin and anti-band 3 or anti-spectrin antibodies levels was found. Anemic patients had higher levels of IgG against both band 3 and spectrin than the non-anemic ones. To determine if these autoantibodies were elicited because of molecular mimicry, we used in silico analysis and identifed P. vivax proteins that share homology with human RBC proteins such as spectrin, suggesting that infection drives autoimmune responses. These fndings suggest that band 3 and spectrin are potential targets of autoantibodies that may be relevant for P. vivax malaria-associated anemia.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28501/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALAnti-band 3 and anti-spectrin.pdfAnti-band 3 and anti-spectrin.pdfapplication/pdf1551592https://www.arca.fiocruz.br/bitstream/icict/28501/2/Anti-band%203%20and%20anti-spectrin.pdfd9272e697efe2ad83fae4cd321d3a3c1MD52TEXTAnti-band 3 and anti-spectrin.pdf.txtAnti-band 3 and anti-spectrin.pdf.txtExtracted texttext/plain59746https://www.arca.fiocruz.br/bitstream/icict/28501/3/Anti-band%203%20and%20anti-spectrin.pdf.txtcdd1da2271d32826638e7dcb46534690MD53icict/285012021-03-24 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| dc.title.pt_BR.fl_str_mv |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| title |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| spellingShingle |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia Mourão, Luiza Carvalho P. vivax malaria P. vivax malaria |
| title_short |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| title_full |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| title_fullStr |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| title_full_unstemmed |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| title_sort |
Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia |
| author |
Mourão, Luiza Carvalho |
| author_facet |
Mourão, Luiza Carvalho Baptista, Rodrigo de Paula Almeida, Zélia Barbosa de Grynberg, Priscila Pucci, Maíra Mazzoni Gomes, Thiago Castro Fontes, Cor Jesus Fernandes Rathore, Sumit Sharma, Yagya D. Pereira, Rosiane Aparecida da Silva Bemquerer, Marcelo Porto Braga, Érika Martins |
| author_role |
author |
| author2 |
Baptista, Rodrigo de Paula Almeida, Zélia Barbosa de Grynberg, Priscila Pucci, Maíra Mazzoni Gomes, Thiago Castro Fontes, Cor Jesus Fernandes Rathore, Sumit Sharma, Yagya D. Pereira, Rosiane Aparecida da Silva Bemquerer, Marcelo Porto Braga, Érika Martins |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mourão, Luiza Carvalho Baptista, Rodrigo de Paula Almeida, Zélia Barbosa de Grynberg, Priscila Pucci, Maíra Mazzoni Gomes, Thiago Castro Fontes, Cor Jesus Fernandes Rathore, Sumit Sharma, Yagya D. Pereira, Rosiane Aparecida da Silva Bemquerer, Marcelo Porto Braga, Érika Martins |
| dc.subject.other.pt_BR.fl_str_mv |
P. vivax malaria |
| topic |
P. vivax malaria P. vivax malaria |
| dc.subject.en.pt_BR.fl_str_mv |
P. vivax malaria |
| description |
2020-01-01 |
| publishDate |
2018 |
| dc.date.accessioned.fl_str_mv |
2018-08-31T15:40:06Z |
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2018-08-31T15:40:06Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
MOURÃO, Luiza Carvalho et al. Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia. Scientific Reports, v. 8, e 8767, 2018 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28501 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
| dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-018-27109-6 |
| identifier_str_mv |
MOURÃO, Luiza Carvalho et al. Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia. Scientific Reports, v. 8, e 8767, 2018 2045-2322 10.1038/s41598-018-27109-6 |
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https://www.arca.fiocruz.br/handle/icict/28501 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Nature Publishing Group |
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Nature Publishing Group |
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