Overview of the organization of protease genes in the genome of Leishmania spp
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10183 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. |
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Almeida, Mariana SilvaSilva, Franklin SouzaPereira, Bernardo Acácio SantiniGuimarães, Michelle Lopes RibeiroAlves, Carlos Roberto2015-05-04T16:34:36Z2015-05-04T16:34:36Z2014ALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014.1756-3305https://www.arca.fiocruz.br/handle/icict/1018310.1186/1756-3305-7-387engBioMed CentralLeishmaniaLeishmaniaLeishmania (Viannia) braziliensisLeishmania (Leishmania) infantumLeishmania (Leishmania) majorLeishmania (Leishmania) mexicanaProteasesLeishmaniaPeptídeo HidrolasesOverview of the organization of protease genes in the genome of Leishmania sppinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Background: The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore classified as virulence factors. Findings: By analyzing protease genes annotated in the genomes of four Leishmania spp [Leishmania (Leishmania) infantum, L. (L.) major, L. (L.) mexicana and L. (Viannia) braziliensis], these genes were found on every chromosome of these protozoa. Four protease classes were studied: metallo-, serine, cysteine and aspartic proteases. Metalloprotease genes predominate in the L. (V.) braziliensis genome, while in the other three species studied, cysteine protease genes prevail. Notably, cysteine and serine protease genes were found to be very abundant, as they were found on all chromosomes of the four studied species. In contrast, only three aspartic protease genes could be detected in these four species. Regarding gene conservation, a higher number of conserved alleles was observed for cysteine proteases (42 alleles), followed by metalloproteases (35 alleles) and serine proteases (15 alleles). Conclusions: The present study highlights substantial differences in the organization of protease genes among L. (L.) infantum, L. (L.) major, L. (L.) mexicana and L. (V.) braziliensis. We observed significant distinctions in many protease features, such as occurrence, quantity and conservation. These data indicate a great diversity of protease genes among Leishmania species, an aspect that may be related to their adaptations to the peculiarities of each microenvironment they inhabit, such as the gut of phlebotomines and the immune cells of vertebrate hosts.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10183/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALmariana_almeidaetal_IOC_2014.pdfapplication/pdf891965https://www.arca.fiocruz.br/bitstream/icict/10183/2/mariana_almeidaetal_IOC_2014.pdff287948f80055bdbf2ebae366305e2e6MD52TEXTmariana_almeidaetal_IOC_2014.pdf.txtmariana_almeidaetal_IOC_2014.pdf.txtExtracted texttext/plain27915https://www.arca.fiocruz.br/bitstream/icict/10183/3/mariana_almeidaetal_IOC_2014.pdf.txtea7ff340eb6ec0ba7713f39a53b6c271MD53icict/101832022-06-24 12:17:32.896oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Overview of the organization of protease genes in the genome of Leishmania spp |
title |
Overview of the organization of protease genes in the genome of Leishmania spp |
spellingShingle |
Overview of the organization of protease genes in the genome of Leishmania spp Almeida, Mariana Silva Leishmania Leishmania Leishmania (Viannia) braziliensis Leishmania (Leishmania) infantum Leishmania (Leishmania) major Leishmania (Leishmania) mexicana Proteases Leishmania Peptídeo Hidrolases |
title_short |
Overview of the organization of protease genes in the genome of Leishmania spp |
title_full |
Overview of the organization of protease genes in the genome of Leishmania spp |
title_fullStr |
Overview of the organization of protease genes in the genome of Leishmania spp |
title_full_unstemmed |
Overview of the organization of protease genes in the genome of Leishmania spp |
title_sort |
Overview of the organization of protease genes in the genome of Leishmania spp |
author |
Almeida, Mariana Silva |
author_facet |
Almeida, Mariana Silva Silva, Franklin Souza Pereira, Bernardo Acácio Santini Guimarães, Michelle Lopes Ribeiro Alves, Carlos Roberto |
author_role |
author |
author2 |
Silva, Franklin Souza Pereira, Bernardo Acácio Santini Guimarães, Michelle Lopes Ribeiro Alves, Carlos Roberto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Mariana Silva Silva, Franklin Souza Pereira, Bernardo Acácio Santini Guimarães, Michelle Lopes Ribeiro Alves, Carlos Roberto |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania |
topic |
Leishmania Leishmania Leishmania (Viannia) braziliensis Leishmania (Leishmania) infantum Leishmania (Leishmania) major Leishmania (Leishmania) mexicana Proteases Leishmania Peptídeo Hidrolases |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania Leishmania (Viannia) braziliensis Leishmania (Leishmania) infantum Leishmania (Leishmania) major Leishmania (Leishmania) mexicana Proteases |
dc.subject.es.pt_BR.fl_str_mv |
Leishmania |
dc.subject.decs.pt_BR.fl_str_mv |
Peptídeo Hidrolases |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-05-04T16:34:36Z |
dc.date.available.fl_str_mv |
2015-05-04T16:34:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10183 |
dc.identifier.issn.pt_BR.fl_str_mv |
1756-3305 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1186/1756-3305-7-387 |
identifier_str_mv |
ALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014. 1756-3305 10.1186/1756-3305-7-387 |
url |
https://www.arca.fiocruz.br/handle/icict/10183 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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BioMed Central |
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BioMed Central |
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