Overview of the organization of protease genes in the genome of Leishmania spp

Detalhes bibliográficos
Autor(a) principal: Almeida, Mariana Silva
Data de Publicação: 2014
Outros Autores: Silva, Franklin Souza, Pereira, Bernardo Acácio Santini, Guimarães, Michelle Lopes Ribeiro, Alves, Carlos Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10183
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
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spelling Almeida, Mariana SilvaSilva, Franklin SouzaPereira, Bernardo Acácio SantiniGuimarães, Michelle Lopes RibeiroAlves, Carlos Roberto2015-05-04T16:34:36Z2015-05-04T16:34:36Z2014ALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014.1756-3305https://www.arca.fiocruz.br/handle/icict/1018310.1186/1756-3305-7-387engBioMed CentralLeishmaniaLeishmaniaLeishmania (Viannia) braziliensisLeishmania (Leishmania) infantumLeishmania (Leishmania) majorLeishmania (Leishmania) mexicanaProteasesLeishmaniaPeptídeo HidrolasesOverview of the organization of protease genes in the genome of Leishmania sppinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Background: The genus Leishmania includes protozoan parasites that are able to infect an array of phlebotomine and vertebrate species. Proteases are related to the capacity of these parasites to infect and survive in their hosts and are therefore classified as virulence factors. Findings: By analyzing protease genes annotated in the genomes of four Leishmania spp [Leishmania (Leishmania) infantum, L. (L.) major, L. (L.) mexicana and L. (Viannia) braziliensis], these genes were found on every chromosome of these protozoa. Four protease classes were studied: metallo-, serine, cysteine and aspartic proteases. Metalloprotease genes predominate in the L. (V.) braziliensis genome, while in the other three species studied, cysteine protease genes prevail. Notably, cysteine and serine protease genes were found to be very abundant, as they were found on all chromosomes of the four studied species. In contrast, only three aspartic protease genes could be detected in these four species. Regarding gene conservation, a higher number of conserved alleles was observed for cysteine proteases (42 alleles), followed by metalloproteases (35 alleles) and serine proteases (15 alleles). Conclusions: The present study highlights substantial differences in the organization of protease genes among L. (L.) infantum, L. (L.) major, L. (L.) mexicana and L. (V.) braziliensis. We observed significant distinctions in many protease features, such as occurrence, quantity and conservation. These data indicate a great diversity of protease genes among Leishmania species, an aspect that may be related to their adaptations to the peculiarities of each microenvironment they inhabit, such as the gut of phlebotomines and the immune cells of vertebrate hosts.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10183/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALmariana_almeidaetal_IOC_2014.pdfapplication/pdf891965https://www.arca.fiocruz.br/bitstream/icict/10183/2/mariana_almeidaetal_IOC_2014.pdff287948f80055bdbf2ebae366305e2e6MD52TEXTmariana_almeidaetal_IOC_2014.pdf.txtmariana_almeidaetal_IOC_2014.pdf.txtExtracted texttext/plain27915https://www.arca.fiocruz.br/bitstream/icict/10183/3/mariana_almeidaetal_IOC_2014.pdf.txtea7ff340eb6ec0ba7713f39a53b6c271MD53icict/101832022-06-24 12:17:32.896oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Overview of the organization of protease genes in the genome of Leishmania spp
title Overview of the organization of protease genes in the genome of Leishmania spp
spellingShingle Overview of the organization of protease genes in the genome of Leishmania spp
Almeida, Mariana Silva
Leishmania
Leishmania
Leishmania (Viannia) braziliensis
Leishmania (Leishmania) infantum
Leishmania (Leishmania) major
Leishmania (Leishmania) mexicana
Proteases
Leishmania
Peptídeo Hidrolases
title_short Overview of the organization of protease genes in the genome of Leishmania spp
title_full Overview of the organization of protease genes in the genome of Leishmania spp
title_fullStr Overview of the organization of protease genes in the genome of Leishmania spp
title_full_unstemmed Overview of the organization of protease genes in the genome of Leishmania spp
title_sort Overview of the organization of protease genes in the genome of Leishmania spp
author Almeida, Mariana Silva
author_facet Almeida, Mariana Silva
Silva, Franklin Souza
Pereira, Bernardo Acácio Santini
Guimarães, Michelle Lopes Ribeiro
Alves, Carlos Roberto
author_role author
author2 Silva, Franklin Souza
Pereira, Bernardo Acácio Santini
Guimarães, Michelle Lopes Ribeiro
Alves, Carlos Roberto
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Mariana Silva
Silva, Franklin Souza
Pereira, Bernardo Acácio Santini
Guimarães, Michelle Lopes Ribeiro
Alves, Carlos Roberto
dc.subject.other.pt_BR.fl_str_mv Leishmania
topic Leishmania
Leishmania
Leishmania (Viannia) braziliensis
Leishmania (Leishmania) infantum
Leishmania (Leishmania) major
Leishmania (Leishmania) mexicana
Proteases
Leishmania
Peptídeo Hidrolases
dc.subject.en.pt_BR.fl_str_mv Leishmania
Leishmania (Viannia) braziliensis
Leishmania (Leishmania) infantum
Leishmania (Leishmania) major
Leishmania (Leishmania) mexicana
Proteases
dc.subject.es.pt_BR.fl_str_mv Leishmania
dc.subject.decs.pt_BR.fl_str_mv Peptídeo Hidrolases
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-04T16:34:36Z
dc.date.available.fl_str_mv 2015-05-04T16:34:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10183
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1756-3305-7-387
identifier_str_mv ALMEIDA, Mariana Silva et al. Overview of the organization of protease genes in the genome of Leishmania spp. Parasites & Vectors, v.7, n.387, 7p, 2014.
1756-3305
10.1186/1756-3305-7-387
url https://www.arca.fiocruz.br/handle/icict/10183
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