CMV and HSV-2 myeloradiculitis in an HIV infected patient

Detalhes bibliográficos
Autor(a) principal: Pinto, Adriana
Data de Publicação: 2011
Outros Autores: Santos, Edwiges, Correa, Danusa F, Escada, Rodrigo, Vorsatz, Carla de Mello, Cardoso, Sandra Wagner, Lima, Marco A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30088
Resumo: Enquanto a mieloradiculite pelo CMV é complicação conhecida em pacientes com SIDA e imunossupressão grave, a mieloradiculite necrosante por HSV-2 é rara e muitas vezes associada a sequelas ou desfecho fatal. Descrevemos um paciente de 46 anos de idade, infectado pelo HIV com imunossupressão profunda e sustentada que apresentou paraparesia aguda ascendente e retenção urinária. A RM de coluna lombar mostrou o realce de contraste no cone medular e cauda equina e ambos PCR para CMV e HSV-2 no LCR foram positivos. Apesar do tratamento, o paciente morreu 20 dias depois. Revisamos os principais aspectos diagnósticos e terapêuticos da mieloradiculite associada aos herpesvírus e discutimos a abordagem em casos semelhantes.
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spelling Pinto, AdrianaSantos, EdwigesCorrea, Danusa FEscada, RodrigoVorsatz, Carla de MelloCardoso, Sandra WagnerLima, Marco A2018-11-19T12:27:54Z2018-11-19T12:27:54Z2011PINTO, Adriana. et al. CMV and HSV-2 myeloradiculitis in an HIV infected patient. Revista do Instituto de Medicina Tropical de São Paulo, v. 53, n. 3, p. 173-175, 2011.0036-4665https://www.arca.fiocruz.br/handle/icict/3008810.1590/S0036-46652011000300010Enquanto a mieloradiculite pelo CMV é complicação conhecida em pacientes com SIDA e imunossupressão grave, a mieloradiculite necrosante por HSV-2 é rara e muitas vezes associada a sequelas ou desfecho fatal. Descrevemos um paciente de 46 anos de idade, infectado pelo HIV com imunossupressão profunda e sustentada que apresentou paraparesia aguda ascendente e retenção urinária. A RM de coluna lombar mostrou o realce de contraste no cone medular e cauda equina e ambos PCR para CMV e HSV-2 no LCR foram positivos. Apesar do tratamento, o paciente morreu 20 dias depois. Revisamos os principais aspectos diagnósticos e terapêuticos da mieloradiculite associada aos herpesvírus e discutimos a abordagem em casos semelhantes.While CMV myeloradiculitis is a known complication in AIDS patients with severe immunosuppression, HSV-2 necrotizing myeloradiculitis is rare and often associated with disabling a fatal outcome. We hereby describe a 46 year-old HIV infected patient with profound and sustained immunosuppression who presented with an acute ascending paraparesis and urinary retention. Lumbar spine MRI showed contrast enhancement at the conus medullaris and cauda equine, and both CMV and HSV-2 CSF PCR were positive. Despite treatment, the patient died 20 days later. We review the main diagnostic and therapeutic aspects of herpes virus associated myeloradiculitis and discuss the approach in similar cases.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. 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dc.title.pt_BR.fl_str_mv CMV and HSV-2 myeloradiculitis in an HIV infected patient
title CMV and HSV-2 myeloradiculitis in an HIV infected patient
spellingShingle CMV and HSV-2 myeloradiculitis in an HIV infected patient
Pinto, Adriana
Cytomegalovirus
Herpes simplex 2
HIV
Myelitis
Foscarnet
Ganciclovir
title_short CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_full CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_fullStr CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_full_unstemmed CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_sort CMV and HSV-2 myeloradiculitis in an HIV infected patient
author Pinto, Adriana
author_facet Pinto, Adriana
Santos, Edwiges
Correa, Danusa F
Escada, Rodrigo
Vorsatz, Carla de Mello
Cardoso, Sandra Wagner
Lima, Marco A
author_role author
author2 Santos, Edwiges
Correa, Danusa F
Escada, Rodrigo
Vorsatz, Carla de Mello
Cardoso, Sandra Wagner
Lima, Marco A
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto, Adriana
Santos, Edwiges
Correa, Danusa F
Escada, Rodrigo
Vorsatz, Carla de Mello
Cardoso, Sandra Wagner
Lima, Marco A
dc.subject.en.pt_BR.fl_str_mv Cytomegalovirus
Herpes simplex 2
HIV
Myelitis
Foscarnet
Ganciclovir
topic Cytomegalovirus
Herpes simplex 2
HIV
Myelitis
Foscarnet
Ganciclovir
description Enquanto a mieloradiculite pelo CMV é complicação conhecida em pacientes com SIDA e imunossupressão grave, a mieloradiculite necrosante por HSV-2 é rara e muitas vezes associada a sequelas ou desfecho fatal. Descrevemos um paciente de 46 anos de idade, infectado pelo HIV com imunossupressão profunda e sustentada que apresentou paraparesia aguda ascendente e retenção urinária. A RM de coluna lombar mostrou o realce de contraste no cone medular e cauda equina e ambos PCR para CMV e HSV-2 no LCR foram positivos. Apesar do tratamento, o paciente morreu 20 dias depois. Revisamos os principais aspectos diagnósticos e terapêuticos da mieloradiculite associada aos herpesvírus e discutimos a abordagem em casos semelhantes.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2018-11-19T12:27:54Z
dc.date.available.fl_str_mv 2018-11-19T12:27:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv PINTO, Adriana. et al. CMV and HSV-2 myeloradiculitis in an HIV infected patient. Revista do Instituto de Medicina Tropical de São Paulo, v. 53, n. 3, p. 173-175, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30088
dc.identifier.issn.pt_BR.fl_str_mv 0036-4665
dc.identifier.doi.none.fl_str_mv 10.1590/S0036-46652011000300010
identifier_str_mv PINTO, Adriana. et al. CMV and HSV-2 myeloradiculitis in an HIV infected patient. Revista do Instituto de Medicina Tropical de São Paulo, v. 53, n. 3, p. 173-175, 2011.
0036-4665
10.1590/S0036-46652011000300010
url https://www.arca.fiocruz.br/handle/icict/30088
dc.language.iso.fl_str_mv eng
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