CMV and HSV-2 myeloradiculitis in an HIV infected patient

Bibliographic Details
Main Author: Pinto, Adriana
Publication Date: 2011
Other Authors: Santos, Edwiges, Correa, Danusa F., Escada, Rodrigo, Vorsatz, Carla de Mello, Cardoso, Sandra Wagner, Lima, Marco A.
Format: Article
Language: eng
Source: Revista do Instituto de Medicina Tropical de São Paulo
Download full: https://www.revistas.usp.br/rimtsp/article/view/31398
Summary: While CMV myeloradiculitis is a known complication in AIDS patients with severe immunosuppression, HSV-2 necrotizing myeloradiculitis is rare and often associated with disabling a fatal outcome. We hereby describe a 46 year-old HIV infected patient with profound and sustained immunosuppression who presented with an acute ascending paraparesis and urinary retention. Lumbar spine MRI showed contrast enhancement at the conus medullaris and cauda equine, and both CMV and HSV-2 CSF PCR were positive. Despite treatment, the patient died 20 days later. We review the main diagnostic and therapeutic aspects of herpes virus associated myeloradiculitis and discuss the approach in similar cases.
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spelling CMV and HSV-2 myeloradiculitis in an HIV infected patient Mieloradiculite por CMV e HSV2 em paciente infectado pelo HIV CytomegalovirusHerpes simplex 2HIVMyelitisFoscarnetGanciclovir While CMV myeloradiculitis is a known complication in AIDS patients with severe immunosuppression, HSV-2 necrotizing myeloradiculitis is rare and often associated with disabling a fatal outcome. We hereby describe a 46 year-old HIV infected patient with profound and sustained immunosuppression who presented with an acute ascending paraparesis and urinary retention. Lumbar spine MRI showed contrast enhancement at the conus medullaris and cauda equine, and both CMV and HSV-2 CSF PCR were positive. Despite treatment, the patient died 20 days later. We review the main diagnostic and therapeutic aspects of herpes virus associated myeloradiculitis and discuss the approach in similar cases. Enquanto a mieloradiculite pelo CMV é complicação conhecida em pacientes com SIDA e imunossupressão grave, a mieloradiculite necrosante por HSV-2 é rara e muitas vezes associada a sequelas ou desfecho fatal. Descrevemos um paciente de 46 anos de idade, infectado pelo HIV com imunossupressão profunda e sustentada que apresentou paraparesia aguda ascendente e retenção urinária. A RM de coluna lombar mostrou o realce de contraste no cone medular e cauda equina e ambos PCR para CMV e HSV-2 no LCR foram positivos. Apesar do tratamento, o paciente morreu 20 dias depois. Revisamos os principais aspectos diagnósticos e terapêuticos da mieloradiculite associada aos herpesvírus e discutimos a abordagem em casos semelhantes. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/31398Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 3 (2011); 173-175 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 3 (2011); 173-175 Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 3 (2011); 173-175 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/31398/33283Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessPinto, AdrianaSantos, EdwigesCorrea, Danusa F.Escada, RodrigoVorsatz, Carla de MelloCardoso, Sandra WagnerLima, Marco A.2012-07-07T19:40:24Zoai:revistas.usp.br:article/31398Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:04.401635Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv CMV and HSV-2 myeloradiculitis in an HIV infected patient
Mieloradiculite por CMV e HSV2 em paciente infectado pelo HIV
title CMV and HSV-2 myeloradiculitis in an HIV infected patient
spellingShingle CMV and HSV-2 myeloradiculitis in an HIV infected patient
Pinto, Adriana
Cytomegalovirus
Herpes simplex 2
HIV
Myelitis
Foscarnet
Ganciclovir
title_short CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_full CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_fullStr CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_full_unstemmed CMV and HSV-2 myeloradiculitis in an HIV infected patient
title_sort CMV and HSV-2 myeloradiculitis in an HIV infected patient
author Pinto, Adriana
author_facet Pinto, Adriana
Santos, Edwiges
Correa, Danusa F.
Escada, Rodrigo
Vorsatz, Carla de Mello
Cardoso, Sandra Wagner
Lima, Marco A.
author_role author
author2 Santos, Edwiges
Correa, Danusa F.
Escada, Rodrigo
Vorsatz, Carla de Mello
Cardoso, Sandra Wagner
Lima, Marco A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pinto, Adriana
Santos, Edwiges
Correa, Danusa F.
Escada, Rodrigo
Vorsatz, Carla de Mello
Cardoso, Sandra Wagner
Lima, Marco A.
dc.subject.por.fl_str_mv Cytomegalovirus
Herpes simplex 2
HIV
Myelitis
Foscarnet
Ganciclovir
topic Cytomegalovirus
Herpes simplex 2
HIV
Myelitis
Foscarnet
Ganciclovir
description While CMV myeloradiculitis is a known complication in AIDS patients with severe immunosuppression, HSV-2 necrotizing myeloradiculitis is rare and often associated with disabling a fatal outcome. We hereby describe a 46 year-old HIV infected patient with profound and sustained immunosuppression who presented with an acute ascending paraparesis and urinary retention. Lumbar spine MRI showed contrast enhancement at the conus medullaris and cauda equine, and both CMV and HSV-2 CSF PCR were positive. Despite treatment, the patient died 20 days later. We review the main diagnostic and therapeutic aspects of herpes virus associated myeloradiculitis and discuss the approach in similar cases.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31398
url https://www.revistas.usp.br/rimtsp/article/view/31398
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/31398/33283
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 No. 3 (2011); 173-175
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 53 Núm. 3 (2011); 173-175
Revista do Instituto de Medicina Tropical de São Paulo; v. 53 n. 3 (2011); 173-175
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
_version_ 1798951647975571456

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