Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer

Detalhes bibliográficos
Autor(a) principal: Marin, Anelis Maria
Data de Publicação: 2023
Outros Autores: Sanchuki, Heloisa Bruna Soligo, Namur, Guilherme Naccache, Uno, Miyuki, Zanette, Dalila Luciola, Aoki, Mateus Nóbrega
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58451
https://doi.org/10.3390/biomedicines11041069
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
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spelling Marin, Anelis MariaSanchuki, Heloisa Bruna SoligoNamur, Guilherme NaccacheUno, MiyukiZanette, Dalila LuciolaAoki, Mateus Nóbrega2023-05-17T11:49:43Z2023-05-17T11:49:43Z2023MARIN, Anelis Maria et al. Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer. Biomedicines, v. 11, n. 10-169, p. 1-25, 2023.2227-9059https://www.arca.fiocruz.br/handle/icict/58451https://doi.org/10.3390/biomedicines11041069porMDPICâncer PancreáticoPancreatic NeoplasmsCell-Free Nucleic AcidsEarly DiagnosisPrognosisNeoplasias PancreáticasÁcidos Nucleicos Libres de CélulasDiagnóstico PrecozPronósticoTumeurs du pancréasAcides nucléiques acellulairesDiagnostic précocePronosticNeoplasias PancreáticasÁcidos Nucleicos LivresDiagnóstico PrecocePrognósticoCirculating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Faculdade de Medicina da Universidade de São Paulo. Departamento de Radiologia e Oncologia. Centro de Investigação Translacional em Oncologia. São Paulo, SP, Brasil. / Faculdade de Medicina da São Paulo. Hospital das Clínicas. São Paulo, SP, Brasil. / Instituto do Câncer do Estado de São Paulo. São Paulo, SP, Brasil.Faculdade de Medicina da Universidade de São Paulo. Departamento de Radiologia e Oncologia. Centro de Investigação Translacional em Oncologia. São Paulo, SP, Brasil. / Faculdade de Medicina da São Paulo. Hospital das Clínicas. São Paulo, SP, Brasil. / Instituto do Câncer do Estado de São Paulo. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.A lack of reliable early diagnostic tools represents a major challenge in the management of pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced stage. This highlights the urgent need to identify biomarkers that can be used for the early detection, staging, treatment monitoring, and prognosis of PCa. A novel approach called liquid biopsy has emerged in recent years, which is a less- or non-invasive procedure since it focuses on plasmatic biomarkers such as DNA and RNA. In the blood of patients with cancer, circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) have been identified such as DNA, mRNA, and non-coding RNA (miRNA and lncRNA). The presence of these molecules encouraged researchers to investigate their potential as biomarkers. In this article, we focused on circulating cfNAs as plasmatic biomarkers of PCa and analyzed their advantages compared to traditional biopsy methods.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58451/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALbiomedicines-11-01069OK.pdfbiomedicines-11-01069OK.pdfapplication/pdf464008https://www.arca.fiocruz.br/bitstream/icict/58451/2/biomedicines-11-01069OK.pdf7c2ae9da440e0d136aa311daff1ba596MD52icict/584512023-05-17 08:49:43.827oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-17T11:49:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
title Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
spellingShingle Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
Marin, Anelis Maria
Câncer Pancreático
Pancreatic Neoplasms
Cell-Free Nucleic Acids
Early Diagnosis
Prognosis
Neoplasias Pancreáticas
Ácidos Nucleicos Libres de Células
Diagnóstico Precoz
Pronóstico
Tumeurs du pancréas
Acides nucléiques acellulaires
Diagnostic précoce
Pronostic
Neoplasias Pancreáticas
Ácidos Nucleicos Livres
Diagnóstico Precoce
Prognóstico
title_short Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
title_full Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
title_fullStr Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
title_full_unstemmed Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
title_sort Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer
author Marin, Anelis Maria
author_facet Marin, Anelis Maria
Sanchuki, Heloisa Bruna Soligo
Namur, Guilherme Naccache
Uno, Miyuki
Zanette, Dalila Luciola
Aoki, Mateus Nóbrega
author_role author
author2 Sanchuki, Heloisa Bruna Soligo
Namur, Guilherme Naccache
Uno, Miyuki
Zanette, Dalila Luciola
Aoki, Mateus Nóbrega
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marin, Anelis Maria
Sanchuki, Heloisa Bruna Soligo
Namur, Guilherme Naccache
Uno, Miyuki
Zanette, Dalila Luciola
Aoki, Mateus Nóbrega
dc.subject.other.en_US.fl_str_mv Câncer Pancreático
topic Câncer Pancreático
Pancreatic Neoplasms
Cell-Free Nucleic Acids
Early Diagnosis
Prognosis
Neoplasias Pancreáticas
Ácidos Nucleicos Libres de Células
Diagnóstico Precoz
Pronóstico
Tumeurs du pancréas
Acides nucléiques acellulaires
Diagnostic précoce
Pronostic
Neoplasias Pancreáticas
Ácidos Nucleicos Livres
Diagnóstico Precoce
Prognóstico
dc.subject.en.en_US.fl_str_mv Pancreatic Neoplasms
Cell-Free Nucleic Acids
Early Diagnosis
Prognosis
dc.subject.es.en_US.fl_str_mv Neoplasias Pancreáticas
Ácidos Nucleicos Libres de Células
Diagnóstico Precoz
Pronóstico
dc.subject.fr.en_US.fl_str_mv Tumeurs du pancréas
Acides nucléiques acellulaires
Diagnostic précoce
Pronostic
dc.subject.decs.en_US.fl_str_mv Neoplasias Pancreáticas
Ácidos Nucleicos Livres
Diagnóstico Precoce
Prognóstico
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-17T11:49:43Z
dc.date.available.fl_str_mv 2023-05-17T11:49:43Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARIN, Anelis Maria et al. Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer. Biomedicines, v. 11, n. 10-169, p. 1-25, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58451
dc.identifier.issn.en_US.fl_str_mv 2227-9059
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3390/biomedicines11041069
identifier_str_mv MARIN, Anelis Maria et al. Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer. Biomedicines, v. 11, n. 10-169, p. 1-25, 2023.
2227-9059
url https://www.arca.fiocruz.br/handle/icict/58451
https://doi.org/10.3390/biomedicines11041069
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58451/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58451/2/biomedicines-11-01069OK.pdf
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