The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis

Detalhes bibliográficos
Autor(a) principal: Oliveira, Pedro Dantas
Data de Publicação: 2022
Outros Autores: Ribeiro, Guilherme Sousa, Anjos, Rosangela Oliveira, Dias, Maria Almeida, Farre, Lourdes, Araújo, Iguaracyra, Bittencourt, Achiléa Lisboa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56350
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Apoio à Pesquisa do Estado da Bahia (FAPESB).
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spelling Oliveira, Pedro DantasRibeiro, Guilherme SousaAnjos, Rosangela OliveiraDias, Maria AlmeidaFarre, LourdesAraújo, IguaracyraBittencourt, Achiléa Lisboa2023-01-06T14:39:21Z2023-01-06T14:39:21Z2022OLIVEIRA, Pedro Dantas et al. The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis. Plos Neglected Tropical Diseases, v. 16, n. 10, p. 1-14, 2022.1935-2735https://www.arca.fiocruz.br/handle/icict/5635010.1371/journal.pntd.0010807Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Apoio à Pesquisa do Estado da Bahia (FAPESB).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Clínica Médica. Salvador, BA, Brasil / Universidade Federal de Sergipe. Departamento de Medicina. Aracaju, SE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Medicina Preventiva e Social. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Clínica Médica. Salvador, BA, Brasil.Oswaldo Cruz Fundação. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Program Against Cancer Therapeutic Resistance. Catalan Institute of Oncology. ONCOBELL. Bellvitge Institute for Biomedical Research. L’Hospitalet del Llobregat. Catalonia, Spain,Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Patologia, Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Patologia, Salvador, BA, Brasil.ackground: Adult T-cell leukemia/lymphoma (ATLL), a peripheral T-cell leukemia/lymphoma associated with the human T-cell lymphotropic virus type-1 (HTLV-1), has been classified following the clinical forms defined by Shimoyama in 1991. A suggestion to modify Shimoyama's classification was proposed in 2007 to differentiate within the smoldering patients those who presented nodules or tumors in the skin without lung involvement, which was named the primary cutaneous tumoral (PCT) form of ATLL. In the present study, according to their clinicopathological characteristics, we estimated the mortality rates of 143 ATLL patients from Bahia, Brazil. We also evaluated the importance of classifying PCT/ATLL separately from the smoldering type on disease prognosis. Methodology/principal findings: Diagnosis of ATLL was established based on a positive serology for HTLV-1, histopathological and/or cytological diagnosis of peripheral T-cell leukemia/lymphoma. Patients were clinically grouped according to Shimoyama's classification, considering PCT variants separately from the smoldering cases. Bivariate and multivariable survival analyses were applied to identify factors associated with disease prognosis. Significant differences in the median survival time were observed between the clinical types, with the smoldering type presenting the longest median survival (109 months) compared to the other forms (<50 months); the median survival for PCT/ATLL was 20 months. Multivariable analysis confirmed that ATLL clinical types were associated with survival, with a better prognosis for patients with the smoldering and chronic types. Furthermore, skin involvement was related to a worse outcome in the multivariable analysis, regardless of the clinical form and presence of lymphadenopathy. Conclusions/significance: Our results reinforce the importance of considering the PCT/ATLL separately from the smoldering type when classifying ATLL to better define prognosis and treatment, given the significant difference in the survival of patients between the smoldering form and PCT/ATLL. Skin involvement should also be considered an independent prognostic factor in patients with ATLL.engPublic Library of ScienceLeucemiaLinfoma de células TClassificação clínicaPrognósticoT-cell leukemiaLymphomaClinical classificationPrognosisLeucemiaLinfoma de células TClassificaçãoPrognósticoThe importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56350/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira, P. D. The importance of the clinical.pdfOliveira, P. D. 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dc.title.en_US.fl_str_mv The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
title The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
spellingShingle The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
Oliveira, Pedro Dantas
Leucemia
Linfoma de células T
Classificação clínica
Prognóstico
T-cell leukemia
Lymphoma
Clinical classification
Prognosis
Leucemia
Linfoma de células T
Classificação
Prognóstico
title_short The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
title_full The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
title_fullStr The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
title_full_unstemmed The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
title_sort The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
author Oliveira, Pedro Dantas
author_facet Oliveira, Pedro Dantas
Ribeiro, Guilherme Sousa
Anjos, Rosangela Oliveira
Dias, Maria Almeida
Farre, Lourdes
Araújo, Iguaracyra
Bittencourt, Achiléa Lisboa
author_role author
author2 Ribeiro, Guilherme Sousa
Anjos, Rosangela Oliveira
Dias, Maria Almeida
Farre, Lourdes
Araújo, Iguaracyra
Bittencourt, Achiléa Lisboa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Pedro Dantas
Ribeiro, Guilherme Sousa
Anjos, Rosangela Oliveira
Dias, Maria Almeida
Farre, Lourdes
Araújo, Iguaracyra
Bittencourt, Achiléa Lisboa
dc.subject.other.en_US.fl_str_mv Leucemia
Linfoma de células T
Classificação clínica
Prognóstico
topic Leucemia
Linfoma de células T
Classificação clínica
Prognóstico
T-cell leukemia
Lymphoma
Clinical classification
Prognosis
Leucemia
Linfoma de células T
Classificação
Prognóstico
dc.subject.en.en_US.fl_str_mv T-cell leukemia
Lymphoma
Clinical classification
Prognosis
dc.subject.decs.en_US.fl_str_mv Leucemia
Linfoma de células T
Classificação
Prognóstico
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Apoio à Pesquisa do Estado da Bahia (FAPESB).
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-06T14:39:21Z
dc.date.available.fl_str_mv 2023-01-06T14:39:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Pedro Dantas et al. The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis. Plos Neglected Tropical Diseases, v. 16, n. 10, p. 1-14, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56350
dc.identifier.issn.en_US.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0010807
identifier_str_mv OLIVEIRA, Pedro Dantas et al. The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis. Plos Neglected Tropical Diseases, v. 16, n. 10, p. 1-14, 2022.
1935-2735
10.1371/journal.pntd.0010807
url https://www.arca.fiocruz.br/handle/icict/56350
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56350/1/license.txt
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