Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Crispim, Myuki Alfaia Esashika
Data de Publicação: 2019
Outros Autores: Reis, Mônica Nogueira da Guarda, Fraiji, Nelson, Bello, Gonzalo, Stefani, Mariane Martins Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40923
Resumo: Acesso aberto em 22/04/20210 - https://onlinelibrary.wiley.com/doi/full/10.1111/trf.15347
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spelling Crispim, Myuki Alfaia EsashikaReis, Mônica Nogueira da GuardaFraiji, NelsonBello, GonzaloStefani, Mariane Martins Araújo2020-04-22T17:51:53Z2020-04-22T17:51:53Z2019CRISPIM, Myuki Alfaia Esashika et al. Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon. Transfusion, v. 59, p. 2593-2601, Aug. 2019.0041-1132https://www.arca.fiocruz.br/handle/icict/4092310.1111/trf.153471537-2995Acesso aberto em 22/04/20210 - https://onlinelibrary.wiley.com/doi/full/10.1111/trf.15347Fundação de Hematologia e Hemoterapia do Amazonas. HEMOAM. Manaus, AM, BrasilUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Imunologia da AIDS e da Hanseniase. Goiânia, GO, Brasil.Fundação de Hematologia e Hemoterapia do Amazonas. HEMOAM. Manaus, AM, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Laboratório de Imunologia da AIDS e da Hanseniase. Goiânia, GO, Brasil.BACKGROUND: This study describes transmitted drug resistance (TDR) in blood donors diagnosed with human immunodeficiency virus Type 1 (HIV-1) infection from 2011 to 2017 in three reference public blood centers from the Northern Brazilian Amazon. STUDY DESIGN AND METHODS: This was a crosssectional study on HIV-positive blood donors from HEMOAM, Manaus, Amazonas, AM (n = 198); HEMERON, Porto Velho, Rondônia, RO (n = 20); and HEMORAIMA, Boa Vista, Roraima, RR (n = 9). HIV-1 pol sequences (protease, reverse transcriptase) were analyzed for drug resistance mutations (DRMs) using the Calibrated Population Resistance tool (Stanford). TDR/DRM clusters were investigated by phylogenetic analysis after removing positions associated with drug resistance of Subtype B sequences from untreated and treated subjects from Northern Brazil. RESULTS: Transmitted drug resistance/DRM in blood donors was 11% (25 of 227), all of them from HEMOAM. Most blood donors with TDR/DRM had multiple and similar DRMs. Nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations predominated (10.1%), followed by nucleoside reverse transcriptase inhibitor (NRTI) mutations (5.3%) and protease inhibitor mutations (0.4%). Dual-class NNRTI/NRTI mutations represented 4.8%. Three highly supported Subtype B monophyletic clades mostly composed by individuals from Amazonas with TDR/DRM mutations were identified. The largest transmission cluster contained 10 sequences, eight from HEMOAM and two sequences described previously (one from a treated subject from Amazonas and the other one from Roraima). This cluster was characterized by NRTI (D67N, T69D, T215S/F/L, K219Q) and NNRTI (K101H, K103 N, G190A) mutations. The other two transmission clades comprised only three and two sequences from HEMOAM sharing the E138A NNRTI mutation. CONCLUSIONS: The identification of transmission clusters of multidrug-resistant viruses in blood donors from Amazonas highlight the need of continued monitoring of TDR/DRM and the importance of pretreatment genotyping in the highly endemic Amazonas state.Brazilian Amazon.engWiley 12 MonthsVírus da imunodeficiência humana Tipo 1Aglomerados filogenéticosMutações de resistência a multidrogasDoadores de sangueAmazônia brasileiraAltamente endêmicaHuman immunodeficiency virus Type 1Phylogenetic clustersMultidrug resistance mutationsBlood donorsNorthern Brazilian AmazonHighly endemicDetection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
title Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
spellingShingle Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
Crispim, Myuki Alfaia Esashika
Vírus da imunodeficiência humana Tipo 1
Aglomerados filogenéticos
Mutações de resistência a multidrogas
Doadores de sangue
Amazônia brasileira
Altamente endêmica
Human immunodeficiency virus Type 1
Phylogenetic clusters
Multidrug resistance mutations
Blood donors
Northern Brazilian Amazon
Highly endemic
title_short Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
title_full Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
title_fullStr Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
title_full_unstemmed Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
title_sort Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon
author Crispim, Myuki Alfaia Esashika
author_facet Crispim, Myuki Alfaia Esashika
Reis, Mônica Nogueira da Guarda
Fraiji, Nelson
Bello, Gonzalo
Stefani, Mariane Martins Araújo
author_role author
author2 Reis, Mônica Nogueira da Guarda
Fraiji, Nelson
Bello, Gonzalo
Stefani, Mariane Martins Araújo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Crispim, Myuki Alfaia Esashika
Reis, Mônica Nogueira da Guarda
Fraiji, Nelson
Bello, Gonzalo
Stefani, Mariane Martins Araújo
dc.subject.other.pt_BR.fl_str_mv Vírus da imunodeficiência humana Tipo 1
Aglomerados filogenéticos
Mutações de resistência a multidrogas
Doadores de sangue
Amazônia brasileira
Altamente endêmica
topic Vírus da imunodeficiência humana Tipo 1
Aglomerados filogenéticos
Mutações de resistência a multidrogas
Doadores de sangue
Amazônia brasileira
Altamente endêmica
Human immunodeficiency virus Type 1
Phylogenetic clusters
Multidrug resistance mutations
Blood donors
Northern Brazilian Amazon
Highly endemic
dc.subject.en.pt_BR.fl_str_mv Human immunodeficiency virus Type 1
Phylogenetic clusters
Multidrug resistance mutations
Blood donors
Northern Brazilian Amazon
Highly endemic
description Acesso aberto em 22/04/20210 - https://onlinelibrary.wiley.com/doi/full/10.1111/trf.15347
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-04-22T17:51:53Z
dc.date.available.fl_str_mv 2020-04-22T17:51:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRISPIM, Myuki Alfaia Esashika et al. Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon. Transfusion, v. 59, p. 2593-2601, Aug. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40923
dc.identifier.issn.pt_BR.fl_str_mv 0041-1132
dc.identifier.doi.none.fl_str_mv 10.1111/trf.15347
dc.identifier.eissn.none.fl_str_mv 1537-2995
identifier_str_mv CRISPIM, Myuki Alfaia Esashika et al. Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon. Transfusion, v. 59, p. 2593-2601, Aug. 2019.
0041-1132
10.1111/trf.15347
1537-2995
url https://www.arca.fiocruz.br/handle/icict/40923
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley 12 Months
publisher.none.fl_str_mv Wiley 12 Months
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40923/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40923/2/GnzaloBello_MonicaReis_etal_IOC_2019.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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