Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36723 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. |
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Sucupira, Michel V. F.Mello, Francisco C. A.Santos, Eneida A.Niel, ChristianRolla, Valeria C.Arabe, JuçaraGomes, Selma A.2019-10-26T18:28:51Z2019-10-26T18:28:51Z2006SUCUPIRA, Michel V. F. et al. Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 6, p. 655-660, Sept. 2006.0074-0276https://www.arca.fiocruz.br/handle/icict/3672310.1590/S0074-027620060006000131678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Vírus da Hepatite BMutaçõesResistência a medicamentosVírus da imunodeficiência humanaLamivudinaHepatitis B virusHuman immunodeficiency virusLamivudineDrug resistanceMutationsPatterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Hepatitis B virus (HBV) molecular profiles were determined for 44 patients who were infected with human immunodeficiency virus (HIV) type 1 and had antibodies to the hepatitis B core antigen (anti-HBc), with and without other HBV serological markers. In this population, 70% of the patients were under lamivudine treatment as a component of antiretroviral therapy. HBV DNA was detected in 14 (32%) patients. Eight out of 12 (67%) HBsAg positive samples, 3/10 (30%) anti-HBc only samples, and 3/22 (14%) anti-HBs positive samples were HBV DNA positive. HBV DNA loads, measured by real time polymerase chain reaction, were much higher in the HBsAg positive patients (mean, 2.5 × 109 copies/ml) than in the negative ones (HBV occult infection; mean, 2.7 × 105 copies/ml). Nine out of the 14 HBV DNA positive patients were under lamivudine treatment. Lamivudine resistant mutations in the polymerase gene were detected in only three patients, all of them belonging to the subgroup of five HBsAg positive, HBV DNA positive patients. A low mean HBV load (2.7 × 105 copies/ml) and an absence of lamivudine resistant mutations were observed among the cases of HBV occult infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36723/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMichelSucupira_ChristianNiel_etal_IOC_2006.pdfMichelSucupira_ChristianNiel_etal_IOC_2006.pdfapplication/pdf534633https://www.arca.fiocruz.br/bitstream/icict/36723/2/MichelSucupira_ChristianNiel_etal_IOC_2006.pdf79f46a4819bff01049b7c9409f1262e8MD52TEXTMichelSucupira_ChristianNiel_etal_IOC_2006.pdf.txtMichelSucupira_ChristianNiel_etal_IOC_2006.pdf.txtExtracted texttext/plain31534https://www.arca.fiocruz.br/bitstream/icict/36723/3/MichelSucupira_ChristianNiel_etal_IOC_2006.pdf.txt982b0d49a7397f39d2e8a7156c3b2cbbMD53icict/367232019-11-26 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| dc.title.pt_BR.fl_str_mv |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| title |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| spellingShingle |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations Sucupira, Michel V. F. Vírus da Hepatite B Mutações Resistência a medicamentos Vírus da imunodeficiência humana Lamivudina Hepatitis B virus Human immunodeficiency virus Lamivudine Drug resistance Mutations |
| title_short |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| title_full |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| title_fullStr |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| title_full_unstemmed |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| title_sort |
Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations |
| author |
Sucupira, Michel V. F. |
| author_facet |
Sucupira, Michel V. F. Mello, Francisco C. A. Santos, Eneida A. Niel, Christian Rolla, Valeria C. Arabe, Juçara Gomes, Selma A. |
| author_role |
author |
| author2 |
Mello, Francisco C. A. Santos, Eneida A. Niel, Christian Rolla, Valeria C. Arabe, Juçara Gomes, Selma A. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Sucupira, Michel V. F. Mello, Francisco C. A. Santos, Eneida A. Niel, Christian Rolla, Valeria C. Arabe, Juçara Gomes, Selma A. |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite B Mutações Resistência a medicamentos Vírus da imunodeficiência humana Lamivudina |
| topic |
Vírus da Hepatite B Mutações Resistência a medicamentos Vírus da imunodeficiência humana Lamivudina Hepatitis B virus Human immunodeficiency virus Lamivudine Drug resistance Mutations |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis B virus Human immunodeficiency virus Lamivudine Drug resistance Mutations |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. |
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2006 |
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2006 |
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2019-10-26T18:28:51Z |
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2019-10-26T18:28:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SUCUPIRA, Michel V. F. et al. Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 6, p. 655-660, Sept. 2006. |
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https://www.arca.fiocruz.br/handle/icict/36723 |
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0074-0276 |
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10.1590/S0074-02762006000600013 |
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1678-8060 |
| identifier_str_mv |
SUCUPIRA, Michel V. F. et al. Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 6, p. 655-660, Sept. 2006. 0074-0276 10.1590/S0074-02762006000600013 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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