In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13948 http://dx.doi.org/10.1016/j.bjp.2015.11.006 |
Resumo: | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. |
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Mansur, Maria Cristina Pinheiro Pereira ReisLeitão, Suzana GuimarãesCoutinho, Cristal CerqueiraVermelho, Alane BeatrizSilva, Ronald SantosPresgrave, Octavio Augusto FrançaLeitão, Alvaro Augusto da CostaLeitão, Gilda GuimarãesRicci Júnior, EduardoSantos, Elisabete Pereira dos2016-04-20T17:16:56Z2016-04-20T17:16:56Z2016MANSUR, M. C. P. P. R. et al. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Rev. Bras. Farmacogn., Curitiba, v. 26, n. 2, p. 251-258, abr. 2016.0102-695Xhttps://www.arca.fiocruz.br/handle/icict/13948http://dx.doi.org/10.1016/j.bjp.2015.11.006engSociedade Brasileira de FarmacognosiaIn vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extractsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Farmacologia e Toxicologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.Chronic exposure to solar radiation could contribute to premature skin aging and skin cancer. Skin presents its own antioxidant defense, however when defenses are out of balance, reactive oxygen species could damage biological structures. In the present work, an oil-in-water photoprotective emulsion was developed and Bauhinia microstachya var. massambabensis Vaz, Fabaceae, extracts at 1% (obtained by extraction with different solvents) were added to this emulsion. In vitro and in vivo efficacy and safety of the formulations were evaluated. Spectrophotometric methods and in vivo Colipa test were performed to evaluated efficacy of the formulations, through sun protection factor (SPF) determination and UVA protection factor assessment. To the in vitro safety assessment HET-CAM, CAM-TBS and Red Blood Cell tests were performed. Results showed that both extracts contributed to a higher in vivo photoprotection (SPF 18) when compared to the formulation without extract (SPF 13), this result could be attributed to the antioxidant activity of the plant extracts that act by capturing reactive oxygen species. Concerning safety, all formulations were considered non-irritant according to in vitro tests. Formulations containing extracts could be considered efficient and safe for cosmetic use since they presented higher sun protection factor and passed the toxicity tests.Leaf ExtractsCosmetic FormulationPhotoprotectionEfficacy and SafetyEvaluation MethodsExtratos VegetaisAditivos em CosméticosAvaliaçãoProtetores SolaresCosméticosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13948/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRev_Bras_Farmacog_26_251-258.pdfRev_Bras_Farmacog_26_251-258.pdfapplication/pdf745298https://www.arca.fiocruz.br/bitstream/icict/13948/2/Rev_Bras_Farmacog_26_251-258.pdfb1394b43a1033d5a33adafc8a487233dMD52TEXTRev_Bras_Farmacog_26_251-258.pdf.txtRev_Bras_Farmacog_26_251-258.pdf.txtExtracted 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| dc.title.en.fl_str_mv |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| title |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| spellingShingle |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts Mansur, Maria Cristina Pinheiro Pereira Reis Leaf Extracts Cosmetic Formulation Photoprotection Efficacy and Safety Evaluation Methods Extratos Vegetais Aditivos em Cosméticos Avaliação Protetores Solares Cosméticos |
| title_short |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| title_full |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| title_fullStr |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| title_full_unstemmed |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| title_sort |
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts |
| author |
Mansur, Maria Cristina Pinheiro Pereira Reis |
| author_facet |
Mansur, Maria Cristina Pinheiro Pereira Reis Leitão, Suzana Guimarães Coutinho, Cristal Cerqueira Vermelho, Alane Beatriz Silva, Ronald Santos Presgrave, Octavio Augusto França Leitão, Alvaro Augusto da Costa Leitão, Gilda Guimarães Ricci Júnior, Eduardo Santos, Elisabete Pereira dos |
| author_role |
author |
| author2 |
Leitão, Suzana Guimarães Coutinho, Cristal Cerqueira Vermelho, Alane Beatriz Silva, Ronald Santos Presgrave, Octavio Augusto França Leitão, Alvaro Augusto da Costa Leitão, Gilda Guimarães Ricci Júnior, Eduardo Santos, Elisabete Pereira dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mansur, Maria Cristina Pinheiro Pereira Reis Leitão, Suzana Guimarães Coutinho, Cristal Cerqueira Vermelho, Alane Beatriz Silva, Ronald Santos Presgrave, Octavio Augusto França Leitão, Alvaro Augusto da Costa Leitão, Gilda Guimarães Ricci Júnior, Eduardo Santos, Elisabete Pereira dos |
| dc.subject.en.en.fl_str_mv |
Leaf Extracts Cosmetic Formulation Photoprotection Efficacy and Safety Evaluation Methods |
| topic |
Leaf Extracts Cosmetic Formulation Photoprotection Efficacy and Safety Evaluation Methods Extratos Vegetais Aditivos em Cosméticos Avaliação Protetores Solares Cosméticos |
| dc.subject.decs.pt_BR.fl_str_mv |
Extratos Vegetais Aditivos em Cosméticos Avaliação Protetores Solares Cosméticos |
| description |
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil. |
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2016 |
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2016-04-20T17:16:56Z |
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2016-04-20T17:16:56Z |
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2016 |
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info:eu-repo/semantics/article |
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MANSUR, M. C. P. P. R. et al. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Rev. Bras. Farmacogn., Curitiba, v. 26, n. 2, p. 251-258, abr. 2016. |
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https://www.arca.fiocruz.br/handle/icict/13948 |
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0102-695X |
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http://dx.doi.org/10.1016/j.bjp.2015.11.006 |
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MANSUR, M. C. P. P. R. et al. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Rev. Bras. Farmacogn., Curitiba, v. 26, n. 2, p. 251-258, abr. 2016. 0102-695X |
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Sociedade Brasileira de Farmacognosia |
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Sociedade Brasileira de Farmacognosia |
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