Dexamethasone, a Drug for Attenuation of Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Pyrrho, Alexandre dos Santos
Data de Publicação: 2002
Outros Autores: Ramos, Juliene Antonio, Neto, Roberto Moura, Silva, Célia Santos da, Lenzi, Henrique Leonel, Takiya, Christina Maeda, Gattass, Cerli Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/4099
Resumo: Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
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spelling Pyrrho, Alexandre dos SantosRamos, Juliene AntonioNeto, Roberto MouraSilva, Célia Santos daLenzi, Henrique LeonelTakiya, Christina MaedaGattass, Cerli Rocha2012-05-28T17:16:50Z2012-05-28T17:16:50Z2002PYRRHO, A. dos S. et al. Dexamethasone, a drug for attenuation of Schistosoma mansoni infection morbidity. Antimicrobial Agents and Chemotherapy, Washington, DC, v.46, n.11, p. 3490-8, Nov. 2002.0066-4804https://www.arca.fiocruz.br/handle/icict/409910.1128/AAC.46.11.3490–3498.2002engAmerican Society for MicrobiologyDexamethasone, a Drug for Attenuation of Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilTo investigate the possible use of immunomodulators as coadjuvants in the treatment of chronic schistosomiasis, the study described in the present report evaluated the effects of dexamethasone on several parameters which reflect disease severity and morbidity. Parasitological, immunological, and histological parameters were analyzed in animals treated from the first day of infection or after 35 days of infection. In both situations, dexamethasone had no effect on the parasite burden but altered the egg distribution in tissue, indicating that under the schedule used it did not interfere with the development of adult worms or oviposition. Treated mice showed a decrease in the number of eggs in hepatic tissue, reduced granuloma sizes, reduced levels of granuloma maturation, and reduced collagen contents. Dexamethasone-treated mice also had decreased gamma interferon, interleukin-12 (IL-12), and IL-4 levels in serum and increased IL-10 levels in serum. Taken together, these data suggested a decrease in the severity of murine schistosomiasis and point to dexamethasone as a convenient and promising coadjuvant agent in the therapy of this infection.DexamethasoneInterferon-gammaAnti-Inflammatory AgentsAspartate AminotransferasesBloodSchistosoma mansoniFibrosisGranulomaDexametasona, uso terapêuticoAntiinflamatóriosAspartato Aminotransferases , uso terapêuticoSchistosoma mansoni, efeitos de drogasFibrose, patologiaGranuloma, patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdfDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdfapplication/pdf316765https://www.arca.fiocruz.br/bitstream/icict/4099/1/Dexamethasone%2c%20a%20Drug%20for%20Attenuation%20of%20Schistosoma%20mansoni.pdf7c26295c935293fd5003067064c47037MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4099/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.txtDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.txtExtracted texttext/plain48710https://www.arca.fiocruz.br/bitstream/icict/4099/5/Dexamethasone%2c%20a%20Drug%20for%20Attenuation%20of%20Schistosoma%20mansoni.pdf.txt86ba61baa4495613271d64699ad1746fMD55THUMBNAILDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.jpgDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.jpgGenerated Thumbnailimage/jpeg2308https://www.arca.fiocruz.br/bitstream/icict/4099/4/Dexamethasone%2c%20a%20Drug%20for%20Attenuation%20of%20Schistosoma%20mansoni.pdf.jpgde709a5436ede34d85dd868735a792f6MD54icict/40992018-04-06 08:58:00.316oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
title Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
spellingShingle Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
Pyrrho, Alexandre dos Santos
Dexamethasone
Interferon-gamma
Anti-Inflammatory Agents
Aspartate Aminotransferases
Blood
Schistosoma mansoni
Fibrosis
Granuloma
Dexametasona, uso terapêutico
Antiinflamatórios
Aspartato Aminotransferases , uso terapêutico
Schistosoma mansoni, efeitos de drogas
Fibrose, patologia
Granuloma, patologia
title_short Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
title_full Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
title_fullStr Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
title_full_unstemmed Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
title_sort Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
author Pyrrho, Alexandre dos Santos
author_facet Pyrrho, Alexandre dos Santos
Ramos, Juliene Antonio
Neto, Roberto Moura
Silva, Célia Santos da
Lenzi, Henrique Leonel
Takiya, Christina Maeda
Gattass, Cerli Rocha
author_role author
author2 Ramos, Juliene Antonio
Neto, Roberto Moura
Silva, Célia Santos da
Lenzi, Henrique Leonel
Takiya, Christina Maeda
Gattass, Cerli Rocha
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pyrrho, Alexandre dos Santos
Ramos, Juliene Antonio
Neto, Roberto Moura
Silva, Célia Santos da
Lenzi, Henrique Leonel
Takiya, Christina Maeda
Gattass, Cerli Rocha
dc.subject.en.pt_BR.fl_str_mv Dexamethasone
Interferon-gamma
Anti-Inflammatory Agents
Aspartate Aminotransferases
Blood
Schistosoma mansoni
Fibrosis
Granuloma
topic Dexamethasone
Interferon-gamma
Anti-Inflammatory Agents
Aspartate Aminotransferases
Blood
Schistosoma mansoni
Fibrosis
Granuloma
Dexametasona, uso terapêutico
Antiinflamatórios
Aspartato Aminotransferases , uso terapêutico
Schistosoma mansoni, efeitos de drogas
Fibrose, patologia
Granuloma, patologia
dc.subject.decs.pt_BR.fl_str_mv Dexametasona, uso terapêutico
Antiinflamatórios
Aspartato Aminotransferases , uso terapêutico
Schistosoma mansoni, efeitos de drogas
Fibrose, patologia
Granuloma, patologia
description Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2012-05-28T17:16:50Z
dc.date.available.fl_str_mv 2012-05-28T17:16:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PYRRHO, A. dos S. et al. Dexamethasone, a drug for attenuation of Schistosoma mansoni infection morbidity. Antimicrobial Agents and Chemotherapy, Washington, DC, v.46, n.11, p. 3490-8, Nov. 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/4099
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.46.11.3490–3498.2002
identifier_str_mv PYRRHO, A. dos S. et al. Dexamethasone, a drug for attenuation of Schistosoma mansoni infection morbidity. Antimicrobial Agents and Chemotherapy, Washington, DC, v.46, n.11, p. 3490-8, Nov. 2002.
0066-4804
10.1128/AAC.46.11.3490–3498.2002
url https://www.arca.fiocruz.br/handle/icict/4099
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language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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