Dexamethasone, a Drug for Attenuation of Schistosoma mansoni
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/4099 |
Resumo: | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil |
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Pyrrho, Alexandre dos SantosRamos, Juliene AntonioNeto, Roberto MouraSilva, Célia Santos daLenzi, Henrique LeonelTakiya, Christina MaedaGattass, Cerli Rocha2012-05-28T17:16:50Z2012-05-28T17:16:50Z2002PYRRHO, A. dos S. et al. Dexamethasone, a drug for attenuation of Schistosoma mansoni infection morbidity. Antimicrobial Agents and Chemotherapy, Washington, DC, v.46, n.11, p. 3490-8, Nov. 2002.0066-4804https://www.arca.fiocruz.br/handle/icict/409910.1128/AAC.46.11.3490–3498.2002engAmerican Society for MicrobiologyDexamethasone, a Drug for Attenuation of Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilTo investigate the possible use of immunomodulators as coadjuvants in the treatment of chronic schistosomiasis, the study described in the present report evaluated the effects of dexamethasone on several parameters which reflect disease severity and morbidity. Parasitological, immunological, and histological parameters were analyzed in animals treated from the first day of infection or after 35 days of infection. In both situations, dexamethasone had no effect on the parasite burden but altered the egg distribution in tissue, indicating that under the schedule used it did not interfere with the development of adult worms or oviposition. Treated mice showed a decrease in the number of eggs in hepatic tissue, reduced granuloma sizes, reduced levels of granuloma maturation, and reduced collagen contents. Dexamethasone-treated mice also had decreased gamma interferon, interleukin-12 (IL-12), and IL-4 levels in serum and increased IL-10 levels in serum. Taken together, these data suggested a decrease in the severity of murine schistosomiasis and point to dexamethasone as a convenient and promising coadjuvant agent in the therapy of this infection.DexamethasoneInterferon-gammaAnti-Inflammatory AgentsAspartate AminotransferasesBloodSchistosoma mansoniFibrosisGranulomaDexametasona, uso terapêuticoAntiinflamatóriosAspartato Aminotransferases , uso terapêuticoSchistosoma mansoni, efeitos de drogasFibrose, patologiaGranuloma, patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdfDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdfapplication/pdf316765https://www.arca.fiocruz.br/bitstream/icict/4099/1/Dexamethasone%2c%20a%20Drug%20for%20Attenuation%20of%20Schistosoma%20mansoni.pdf7c26295c935293fd5003067064c47037MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4099/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.txtDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.txtExtracted texttext/plain48710https://www.arca.fiocruz.br/bitstream/icict/4099/5/Dexamethasone%2c%20a%20Drug%20for%20Attenuation%20of%20Schistosoma%20mansoni.pdf.txt86ba61baa4495613271d64699ad1746fMD55THUMBNAILDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.jpgDexamethasone, a Drug for Attenuation of Schistosoma mansoni.pdf.jpgGenerated Thumbnailimage/jpeg2308https://www.arca.fiocruz.br/bitstream/icict/4099/4/Dexamethasone%2c%20a%20Drug%20for%20Attenuation%20of%20Schistosoma%20mansoni.pdf.jpgde709a5436ede34d85dd868735a792f6MD54icict/40992018-04-06 08:58:00.316oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
title |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
spellingShingle |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni Pyrrho, Alexandre dos Santos Dexamethasone Interferon-gamma Anti-Inflammatory Agents Aspartate Aminotransferases Blood Schistosoma mansoni Fibrosis Granuloma Dexametasona, uso terapêutico Antiinflamatórios Aspartato Aminotransferases , uso terapêutico Schistosoma mansoni, efeitos de drogas Fibrose, patologia Granuloma, patologia |
title_short |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
title_full |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
title_fullStr |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
title_full_unstemmed |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
title_sort |
Dexamethasone, a Drug for Attenuation of Schistosoma mansoni |
author |
Pyrrho, Alexandre dos Santos |
author_facet |
Pyrrho, Alexandre dos Santos Ramos, Juliene Antonio Neto, Roberto Moura Silva, Célia Santos da Lenzi, Henrique Leonel Takiya, Christina Maeda Gattass, Cerli Rocha |
author_role |
author |
author2 |
Ramos, Juliene Antonio Neto, Roberto Moura Silva, Célia Santos da Lenzi, Henrique Leonel Takiya, Christina Maeda Gattass, Cerli Rocha |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pyrrho, Alexandre dos Santos Ramos, Juliene Antonio Neto, Roberto Moura Silva, Célia Santos da Lenzi, Henrique Leonel Takiya, Christina Maeda Gattass, Cerli Rocha |
dc.subject.en.pt_BR.fl_str_mv |
Dexamethasone Interferon-gamma Anti-Inflammatory Agents Aspartate Aminotransferases Blood Schistosoma mansoni Fibrosis Granuloma |
topic |
Dexamethasone Interferon-gamma Anti-Inflammatory Agents Aspartate Aminotransferases Blood Schistosoma mansoni Fibrosis Granuloma Dexametasona, uso terapêutico Antiinflamatórios Aspartato Aminotransferases , uso terapêutico Schistosoma mansoni, efeitos de drogas Fibrose, patologia Granuloma, patologia |
dc.subject.decs.pt_BR.fl_str_mv |
Dexametasona, uso terapêutico Antiinflamatórios Aspartato Aminotransferases , uso terapêutico Schistosoma mansoni, efeitos de drogas Fibrose, patologia Granuloma, patologia |
description |
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002 |
dc.date.accessioned.fl_str_mv |
2012-05-28T17:16:50Z |
dc.date.available.fl_str_mv |
2012-05-28T17:16:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PYRRHO, A. dos S. et al. Dexamethasone, a drug for attenuation of Schistosoma mansoni infection morbidity. Antimicrobial Agents and Chemotherapy, Washington, DC, v.46, n.11, p. 3490-8, Nov. 2002. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/4099 |
dc.identifier.issn.none.fl_str_mv |
0066-4804 |
dc.identifier.doi.none.fl_str_mv |
10.1128/AAC.46.11.3490–3498.2002 |
identifier_str_mv |
PYRRHO, A. dos S. et al. Dexamethasone, a drug for attenuation of Schistosoma mansoni infection morbidity. Antimicrobial Agents and Chemotherapy, Washington, DC, v.46, n.11, p. 3490-8, Nov. 2002. 0066-4804 10.1128/AAC.46.11.3490–3498.2002 |
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https://www.arca.fiocruz.br/handle/icict/4099 |
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American Society for Microbiology |
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American Society for Microbiology |
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