Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1995 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/4068 http://dx.doi.org/10.1590/S0074-02761995000200034 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
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Lenzi, Jane A.Mota, Ester MariaMachado, Marcelo PelajoPaiva, R. A.Lenzi, Henrique Leonel2012-05-15T14:16:07Z2012-05-15T14:16:07Z1995LENZI, J. A. et al. Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.90, n.2, p.311-318. Apr. 1995.0074-0276https://www.arca.fiocruz.br/handle/icict/4068http://dx.doi.org/10.1590/S0074-02761995000200034engFundação Oswaldo Cruz. Instituto Oswaldo CruzFundação Oswaldo Cruz. Instituto Oswaldo CruzCalomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Twenty Calomys callosus, Rengger, 1830 (Rodentia-Cricetidae) were studied in the early stage of the acute schistosomal mansoni infection (42nd day). The same number of Swiss Webster mice were used as a comparative standard. Liver and intestinal sections, fixed in formalin-Millonig and embedded in paraffin, were stained with hematoxilin and eosin, PAS-Alcian Blue, pH = 1.0 and 2.5, Lennert's Giemsa, Picrosirius plus polarization microscopy, Periodic acid methanamine silver, Gomori's silver reticulin and resorcin-fuchsin. Immunohistological study (indirect immunofluorescence and peroxidase labeled extravidin-biotin methods) was done with antibodies specific to pro-collagen III, fibronectin, elastin, condroitin-sulfate, tenascin, α smooth muscle actin, vimentin and desmin. The hepatic granulomas were small, reaching only 27 of the volume of the hepatic Swiss Webster granuloma. They were composed mainly by large immature macrophages, often filled by schistosomal pigment, characterizing an exsudative-macrophage granuloma type. The granulomas were situated in the parenchyma and in the portal space. They were often intravascular, poor of extracellular matrix components, except fibronectin and presented, sometimes α smooth muscle actin and vimentin positive cells. The C. callosus intestinal granulomas were similar to Swiss Webster, showing predominance of macrophages. Therefore, the C. callosus acquire very well the Schistosoma mansoni infection, without developing strong hepatic acute granulomatous reaction, suggesting lack of histopathological signs of hypersensitivity.Colomys callosusIntestineGranulomaExtracellular matrixFibrosisLiverSchistosoma mansoniSchistosoma mansoniGranulomaMatriz ExtracelularFibroseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCalomys callosus.pdfCalomys callosus.pdfapplication/pdf5194144https://www.arca.fiocruz.br/bitstream/icict/4068/1/Calomys%20callosus.pdfb32fe4a032e1ed9011f88c1fc2b81ff6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4068/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCalomys callosus.pdf.txtCalomys callosus.pdf.txtExtracted texttext/plain8https://www.arca.fiocruz.br/bitstream/icict/4068/5/Calomys%20callosus.pdf.txt8d1b69dd9bdc9df4a8073c7a8193c7afMD55THUMBNAILCalomys callosus.pdf.jpgCalomys callosus.pdf.jpgGenerated Thumbnailimage/jpeg2733https://www.arca.fiocruz.br/bitstream/icict/4068/4/Calomys%20callosus.pdf.jpg600b5cba7234102b2cabbc67d3794c3fMD54icict/40682018-04-06 09:02:49.663oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:02:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| title |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| spellingShingle |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase Lenzi, Jane A. Colomys callosus Intestine Granuloma Extracellular matrix Fibrosis Liver Schistosoma mansoni Schistosoma mansoni Granuloma Matriz Extracelular Fibrose |
| title_short |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| title_full |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| title_fullStr |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| title_full_unstemmed |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| title_sort |
Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase |
| author |
Lenzi, Jane A. |
| author_facet |
Lenzi, Jane A. Mota, Ester Maria Machado, Marcelo Pelajo Paiva, R. A. Lenzi, Henrique Leonel |
| author_role |
author |
| author2 |
Mota, Ester Maria Machado, Marcelo Pelajo Paiva, R. A. Lenzi, Henrique Leonel |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Lenzi, Jane A. Mota, Ester Maria Machado, Marcelo Pelajo Paiva, R. A. Lenzi, Henrique Leonel |
| dc.subject.en.pt_BR.fl_str_mv |
Colomys callosus Intestine Granuloma Extracellular matrix Fibrosis Liver Schistosoma mansoni |
| topic |
Colomys callosus Intestine Granuloma Extracellular matrix Fibrosis Liver Schistosoma mansoni Schistosoma mansoni Granuloma Matriz Extracelular Fibrose |
| dc.subject.decs.pt_BR.fl_str_mv |
Schistosoma mansoni Granuloma Matriz Extracelular Fibrose |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. |
| publishDate |
1995 |
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1995 |
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2012-05-15T14:16:07Z |
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2012-05-15T14:16:07Z |
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info:eu-repo/semantics/article |
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LENZI, J. A. et al. Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.90, n.2, p.311-318. Apr. 1995. |
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https://www.arca.fiocruz.br/handle/icict/4068 |
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0074-0276 |
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http://dx.doi.org/10.1590/S0074-02761995000200034 |
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LENZI, J. A. et al. Calomys callosus: an alternative model to study fibrosis in Schistosomiasis mansoni: the pathology of the acute phase. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.90, n.2, p.311-318. Apr. 1995. 0074-0276 |
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https://www.arca.fiocruz.br/handle/icict/4068 http://dx.doi.org/10.1590/S0074-02761995000200034 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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