Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015

Detalhes bibliográficos
Autor(a) principal: Salla, L. C.
Data de Publicação: 2020
Outros Autores: Rodrigues, P. T., Corder, R. M., Johansen, I. C., Ladeia_Andrade, S., Ferreira, M. U.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42306
Resumo: Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.
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spelling Salla, L. C.Rodrigues, P. T.Corder, R. M.Johansen, I. C.Ladeia_Andrade, S.Ferreira, M. U.2020-07-20T18:53:45Z2020-07-20T18:53:45Z2020SALLA, L. C. et al. Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015. Ecology and Infection, v.48, e47, p. 1-8, 2020.0950-2688https://www.arca.fiocruz.br/handle/icict/4230610.1017/S09502688200005151469-4409engCambridge University PressAmazôniaEpidemiologia molecularEstrutura populacionalÁrea urbanaAmazonMalariaMolecular epidemiologyUrbanMolecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.The relative contribution of imported vs. locally acquired infections to urban malaria burden remains largely unexplored in Latin America, the most urbanised region in the developing world. Here we use a simple molecular epidemiology framework to examine the transmission dynamics of Plasmodium vivax in Mâncio Lima, the Amazonian municipality with the highest malaria incidence rate in Brazil. We prospectively genotyped 177 P. vivax infections diagnosed in urban residents between June 2014 and July 2015 and showed that local parasites are structured into several lineages of closely related microsatellite haplotypes, with the largest genetic cluster comprising 32% of all infections. These findings are very unlikely under the hypothesis of multiple independent imports of parasite strains from the rural surroundings. Instead, the presence of an endemic near-clonal parasite lineage circulating over 13 consecutive months is consistent with a local P. vivax transmission chain in the town, with major implications for malaria elimination efforts in this and similar urban environments across the Amazon.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42306/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSLadeia_Andrade_etal_IOC_2020.pdfSLadeia_Andrade_etal_IOC_2020.pdfapplication/pdf461301https://www.arca.fiocruz.br/bitstream/icict/42306/2/SLadeia_Andrade_etal_IOC_2020.pdfbb9385a445ea824f5e0b360e160a9189MD52TEXTSLadeia_Andrade_etal_IOC_2020.pdf.txtSLadeia_Andrade_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
title Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
spellingShingle Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
Salla, L. C.
Amazônia
Epidemiologia molecular
Estrutura populacional
Área urbana
Amazon
Malaria
Molecular epidemiology
Urban
title_short Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
title_full Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
title_fullStr Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
title_full_unstemmed Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
title_sort Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015
author Salla, L. C.
author_facet Salla, L. C.
Rodrigues, P. T.
Corder, R. M.
Johansen, I. C.
Ladeia_Andrade, S.
Ferreira, M. U.
author_role author
author2 Rodrigues, P. T.
Corder, R. M.
Johansen, I. C.
Ladeia_Andrade, S.
Ferreira, M. U.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Salla, L. C.
Rodrigues, P. T.
Corder, R. M.
Johansen, I. C.
Ladeia_Andrade, S.
Ferreira, M. U.
dc.subject.other.pt_BR.fl_str_mv Amazônia
Epidemiologia molecular
Estrutura populacional
Área urbana
topic Amazônia
Epidemiologia molecular
Estrutura populacional
Área urbana
Amazon
Malaria
Molecular epidemiology
Urban
dc.subject.en.pt_BR.fl_str_mv Amazon
Malaria
Molecular epidemiology
Urban
description Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-20T18:53:45Z
dc.date.available.fl_str_mv 2020-07-20T18:53:45Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALLA, L. C. et al. Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015. Ecology and Infection, v.48, e47, p. 1-8, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42306
dc.identifier.issn.pt_BR.fl_str_mv 0950-2688
dc.identifier.doi.none.fl_str_mv 10.1017/S0950268820000515
dc.identifier.eissn.none.fl_str_mv 1469-4409
identifier_str_mv SALLA, L. C. et al. Molecular evidence of sustained urban malaria transmission in Amazonian Brazil, 2014–2015. Ecology and Infection, v.48, e47, p. 1-8, 2020.
0950-2688
10.1017/S0950268820000515
1469-4409
url https://www.arca.fiocruz.br/handle/icict/42306
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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