0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury

Detalhes bibliográficos
Autor(a) principal: Rasinhas, Arthur da Costa
Data de Publicação: 2023
Outros Autores: Jácome, Fernanda Cunha, Caldas, Gabriela Cardoso, Almeida, Ana Luisa Teixeira de, Souza, Daniel Dias Coutinho de, Santos, João Paulo Rodrigues dos, Dias, Helver Gonçalves, Araujo, Eduarda Lima, Borges, Ronaldo Mohana, Barth, Ortrud Monika, Santos, Flavia Barreto dos, Vieira, Debora Ferreira Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57789
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
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spelling Rasinhas, Arthur da CostaJácome, Fernanda CunhaCaldas, Gabriela CardosoAlmeida, Ana Luisa Teixeira deSouza, Daniel Dias Coutinho deSantos, João Paulo Rodrigues dosDias, Helver GonçalvesAraujo, Eduarda LimaBorges, Ronaldo MohanaBarth, Ortrud MonikaSantos, Flavia Barreto dosVieira, Debora Ferreira Barreto2023-04-14T15:07:43Z2023-04-14T15:07:43Z2023RASINHAS, Arthur da Costa et al. 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, 2023.1678-8070https://www.arca.fiocruz.br/handle/icict/5778910.1590/0074-02760220255engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.DENV-4Camundongos BALB/cRIMHistopatologiaUltra estruturaDENV-4BALB/c miceKIDNEYHistopatologyUltrastructure0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil .Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Laboratório de Biotecnologia e Bioengenharia Estrutural. Rio de Janeiro, RJ, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil.Dengue is a disease caused by dengue virus (DENV-1 through -4), and is responsible for over 300 million cases worldwide. Among the four serotypes, DENV-4 remains the least studied, with limited data on the histopathology of the disease. Acute kidney injury is a potential complication of dengue generally associated with severe dengue infection. This reinforces the need for a better understanding of the consequences of dengue infection in renal tissue. Recently, the BALB/c mouse strain has gained ground as a competent model for experimental dengue infection. In this study, BALB/c mice were infected through the intravenous route with a DENV-4 strain, isolated from a human patient. The kidneys of the mice were procured and subject to histopathological and ultrastructural analysis. The presence of the viral antigen was confirmed through immunohistochemistry. Analysis of tissue sections revealed the presence of inflammatory cell infiltrate throughout the parenchyma. Glomerular enlargement was a common find. Necrosis of tubular cells and hemorrhage were also observed. Analysis of the kidney on a transmission electron microscope allowed a closer look into the necrotic tubular cells, which presented nuclei with condensed chromatin, and loss of cytoplasm. Even though the kidney is probably not a primary target of dengue infection in mice, the inoculation of the virus in the blood appears to damage the renal tissue through local inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57789/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALArthurRasinhas_MonikaBarth_etal_IOC_2023.pdfArthurRasinhas_MonikaBarth_etal_IOC_2023.pdfapplication/pdf1064207https://www.arca.fiocruz.br/bitstream/icict/57789/4/ArthurRasinhas_MonikaBarth_etal_IOC_2023.pdf7858e127b0fd3b9f7646b1737fe5d36aMD54icict/577892023-09-14 15:53:35.057oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:53:35Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
title 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
spellingShingle 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
Rasinhas, Arthur da Costa
DENV-4
Camundongos BALB/c
RIM
Histopatologia
Ultra estrutura
DENV-4
BALB/c mice
KIDNEY
Histopatology
Ultrastructure
title_short 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
title_full 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
title_fullStr 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
title_full_unstemmed 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
title_sort 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury
author Rasinhas, Arthur da Costa
author_facet Rasinhas, Arthur da Costa
Jácome, Fernanda Cunha
Caldas, Gabriela Cardoso
Almeida, Ana Luisa Teixeira de
Souza, Daniel Dias Coutinho de
Santos, João Paulo Rodrigues dos
Dias, Helver Gonçalves
Araujo, Eduarda Lima
Borges, Ronaldo Mohana
Barth, Ortrud Monika
Santos, Flavia Barreto dos
Vieira, Debora Ferreira Barreto
author_role author
author2 Jácome, Fernanda Cunha
Caldas, Gabriela Cardoso
Almeida, Ana Luisa Teixeira de
Souza, Daniel Dias Coutinho de
Santos, João Paulo Rodrigues dos
Dias, Helver Gonçalves
Araujo, Eduarda Lima
Borges, Ronaldo Mohana
Barth, Ortrud Monika
Santos, Flavia Barreto dos
Vieira, Debora Ferreira Barreto
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rasinhas, Arthur da Costa
Jácome, Fernanda Cunha
Caldas, Gabriela Cardoso
Almeida, Ana Luisa Teixeira de
Souza, Daniel Dias Coutinho de
Santos, João Paulo Rodrigues dos
Dias, Helver Gonçalves
Araujo, Eduarda Lima
Borges, Ronaldo Mohana
Barth, Ortrud Monika
Santos, Flavia Barreto dos
Vieira, Debora Ferreira Barreto
dc.subject.other.en_US.fl_str_mv DENV-4
Camundongos BALB/c
RIM
Histopatologia
Ultra estrutura
topic DENV-4
Camundongos BALB/c
RIM
Histopatologia
Ultra estrutura
DENV-4
BALB/c mice
KIDNEY
Histopatology
Ultrastructure
dc.subject.en.en_US.fl_str_mv DENV-4
BALB/c mice
KIDNEY
Histopatology
Ultrastructure
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogenese Viral. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-04-14T15:07:43Z
dc.date.available.fl_str_mv 2023-04-14T15:07:43Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RASINHAS, Arthur da Costa et al. 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57789
dc.identifier.issn.en_US.fl_str_mv 1678-8070
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760220255
identifier_str_mv RASINHAS, Arthur da Costa et al. 0255_Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, 2023.
1678-8070
10.1590/0074-02760220255
url https://www.arca.fiocruz.br/handle/icict/57789
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57789/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57789/4/ArthurRasinhas_MonikaBarth_etal_IOC_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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