The neovaginal microbiome of transgender women post-gender reassignment surgery
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41252 |
Resumo: | Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada. |
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Birse, Kenzie D.Kratzer, KaterynaZuend, Christina FarrMutch, SarahNoël-Romas, LauraLamont, AlanaAbou, MaxJalil, EmiliaVeloso, Valdiléa G.Grinsztejn, BeatrizFriedman, Ruth KhaliliBroliden, KristinaBradley, FrideborgPoliquin, VanessaLi, FanYanavich, CarolynBurgener, AdamAldrovandi, Grace2020-05-14T22:01:28Z2020-05-14T22:01:28Z2020BIRSE, Kenzie D. et al. The neovaginal microbiome of transgender women post-gender reassignment surgery. Microbiome, v. 8, n. 61, p. 1-13, 2020.2049-2618https://www.arca.fiocruz.br/handle/icict/4125210.1186/s40168-020-00804-1engBMCThe neovaginal microbiome of transgender women post-gender reassignment surgeryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePublic Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Karolinska University Hospital. Karolinska Institutet. Unit of Infectious Diseases. Center for Molecular Medicine. Department of Medicine Solna. Stockholm, Sweden.Karolinska University Hospital. Karolinska Institutet. Unit of Infectious Diseases. Center for Molecular Medicine. Department of Medicine Solna. Stockholm, Sweden.University of Manitoba. Department of Obstetrics & Gynecology. Winnipeg, MB, Canada.University of California. Los Angeles, CA, USA.University of California. Los Angeles, CA, USA.Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada / Karolinska University Hospital. Karolinska Institutet. Unit of Infectious Diseases. Center for Molecular Medicine. Department of Medicine Solna. Stockholm, Sweden / University of Manitoba. Department of Obstetrics & Gynecology. Winnipeg, MB, Canada.University of California. Los Angeles, CA, USA.Background: Gender reassignment surgery is a procedure some transgender women (TW) undergo for genderaffirming purposes. This often includes the construction of a neovagina using existing penile and scrotal tissue and/or a sigmoid colon graft. There are limited data regarding the composition and function of the neovaginal microbiome representing a major gap in knowledge in neovaginal health. Results: Metaproteomics was performed on secretions collected from the neovaginas (n = 5) and rectums (n = 7) of TW surgically reassigned via penile inversion/scrotal graft with (n = 1) or without (n = 4) a sigmoid colon graft extension and compared with secretions from cis vaginas (n = 32). We identified 541 unique bacterial proteins from 38 taxa. The most abundant taxa in the neovaginas were Porphyromonas (30.2%), Peptostreptococcus (9.2%), Prevotella (9.0%), Mobiluncus (8.0%), and Jonquetella (7.2%), while cis vaginas were primarily Lactobacillus and Gardnerella. Rectal samples were mainly composed of Prevotella and Roseburia. Neovaginas (median Shannon’s H index = 1.33) had higher alpha diversity compared to cis vaginas (Shannon’s H = 0.35) (p = 7.2E−3, Mann-Whitney U test) and were more similar to the non-Lactobacillus dominant/polymicrobial cis vaginas based on beta diversity (perMANOVA, p = 0.001, r 2 = 0.342). In comparison to cis vaginas, toll-like receptor response, amino acid, and shortchain fatty acid metabolic pathways were increased (p < 0.01), while keratinization and cornification proteins were decreased (p < 0.001) in the neovaginal proteome. Conclusions: Penile skin-lined neovaginas have diverse, polymicrobial communities that show similarities in composition to uncircumcised penises and host responses to cis vaginas with bacterial vaginosis (BV) including increased immune activation pathways and decreased epithelial barrier function. Developing a better understanding of microbiome-associated inflammation in the neovaginal environment will be important for improving our knowledge of neovaginal health.Gender reassignment surgeryMetaproteomicsMicrobiomeNeovaginaTransgender womeninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/41252/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALThe neovaginal_Emilia_Jalil_INI_LapClin-AIDS_2020.pdfThe neovaginal_Emilia_Jalil_INI_LapClin-AIDS_2020.pdfapplication/pdf1836874https://www.arca.fiocruz.br/bitstream/icict/41252/2/The%20neovaginal_Emilia_Jalil_INI_LapClin-AIDS_2020.pdf718632a7f9d347fa181d50854c6cdd73MD52TEXTThe neovaginal_Emilia_Jalil_INI_LapClin-AIDS_2020.pdf.txtThe neovaginal_Emilia_Jalil_INI_LapClin-AIDS_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
title |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
spellingShingle |
The neovaginal microbiome of transgender women post-gender reassignment surgery Birse, Kenzie D. Gender reassignment surgery Metaproteomics Microbiome Neovagina Transgender women |
title_short |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
title_full |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
title_fullStr |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
title_full_unstemmed |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
title_sort |
The neovaginal microbiome of transgender women post-gender reassignment surgery |
author |
Birse, Kenzie D. |
author_facet |
Birse, Kenzie D. Kratzer, Kateryna Zuend, Christina Farr Mutch, Sarah Noël-Romas, Laura Lamont, Alana Abou, Max Jalil, Emilia Veloso, Valdiléa G. Grinsztejn, Beatriz Friedman, Ruth Khalili Broliden, Kristina Bradley, Frideborg Poliquin, Vanessa Li, Fan Yanavich, Carolyn Burgener, Adam Aldrovandi, Grace |
author_role |
author |
author2 |
Kratzer, Kateryna Zuend, Christina Farr Mutch, Sarah Noël-Romas, Laura Lamont, Alana Abou, Max Jalil, Emilia Veloso, Valdiléa G. Grinsztejn, Beatriz Friedman, Ruth Khalili Broliden, Kristina Bradley, Frideborg Poliquin, Vanessa Li, Fan Yanavich, Carolyn Burgener, Adam Aldrovandi, Grace |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Birse, Kenzie D. Kratzer, Kateryna Zuend, Christina Farr Mutch, Sarah Noël-Romas, Laura Lamont, Alana Abou, Max Jalil, Emilia Veloso, Valdiléa G. Grinsztejn, Beatriz Friedman, Ruth Khalili Broliden, Kristina Bradley, Frideborg Poliquin, Vanessa Li, Fan Yanavich, Carolyn Burgener, Adam Aldrovandi, Grace |
dc.subject.en.pt_BR.fl_str_mv |
Gender reassignment surgery Metaproteomics Microbiome Neovagina Transgender women |
topic |
Gender reassignment surgery Metaproteomics Microbiome Neovagina Transgender women |
description |
Public Health Agency of Canada. JC Wilt Infectious Disease Research Centre. National HIV and Retrovirology Labs. Winnipeg, MB, Canada / University of Manitoba. Departments of Medical Microbiology and Infectious Disease. Winnipeg, MB, Canada. |
publishDate |
2020 |
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2020-05-14T22:01:28Z |
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2020-05-14T22:01:28Z |
dc.date.issued.fl_str_mv |
2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BIRSE, Kenzie D. et al. The neovaginal microbiome of transgender women post-gender reassignment surgery. Microbiome, v. 8, n. 61, p. 1-13, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/41252 |
dc.identifier.issn.pt_BR.fl_str_mv |
2049-2618 |
dc.identifier.doi.none.fl_str_mv |
10.1186/s40168-020-00804-1 |
identifier_str_mv |
BIRSE, Kenzie D. et al. The neovaginal microbiome of transgender women post-gender reassignment surgery. Microbiome, v. 8, n. 61, p. 1-13, 2020. 2049-2618 10.1186/s40168-020-00804-1 |
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https://www.arca.fiocruz.br/handle/icict/41252 |
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eng |
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BMC |
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