Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55141 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Souza, Diego Pereira deGonçalves, José Francisco de CarvalhoCarvalho, Josiane Celerino deSilva, Karyne Kathlen Guedes daFernandes, Andreia VarmesNascimento, Gleisson de OliveiraRamos, Marcio VianaKoolen, Hector Henrique FerreiraBezerra, Daniel PereiraSantos, Alberdan Silva2022-10-14T15:29:15Z2022-10-14T15:29:15Z2022SOUZA, Diego Pereira de et al. Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora Ducke. Industrial Crops & Products, v. 186, p. 1-11, 2022.1872-633Xhttps://www.arca.fiocruz.br/handle/icict/5514110.1016/j.indcrop.2022.115180Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal de São Carlos. Departamento de Química, São Carlos, SP, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Fisiologia e Bioquímica Vegetal. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Fisiologia e Bioquímica Vegetal. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Fisiologia e Bioquímica Vegetal. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Fisiologia e Bioquímica Vegetal. Manaus, AM, Brasil.Universidade Federal do Acre. Centro Multidisciplinar. Cruzeiro do Sul, AC, Brasil.Universidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, Brasil.Universidade do Estado do Amazonas. Grupo de Pesquisa em Metabolômica e Espectrometria de Massa. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Pará. Laboratório de Investigação Sistemática em Biotecnologia e Biodiversidade Molecular. Belém, Pará, Brasil.Plant oils are sources of metabolites that have enormous potential for industrial applications. Herein, the chemical profile and in vitro antimicrobial activity of the essential oil (EO) from the leaves of Guatteria citriodora Ducke (Annonaceae) have been investigated for the first time. The composition of the hydrodistilled EO was analyzed using gas chromatography-mass spectrometry (GC-MS), which permitted the identification of oxygenated monoterpenes as the most highly representative class, and included citronellal (40.99%) and citronellol (14.6%) as the main compounds. The antimicrobial activity of G. citriodora EO (GcEO) was evaluated against pathogenic bacteria and phytopathogenic fungi. The experimental design was completely randomized (CRD), and used doses for each microorganism. Gram-positive strains were the most sensitive with a minimum inhibitory concentration (MIC) of 5.0 μL mL−1, while Gram-negative strains were 10.0 μL mL−1. The most potent antifungal activity was against Alternaria alternata (MIC of 1.25 μL mL−1). In addition, it fully inhibited A. alternata conidia germination at the minimum inhibitory concentration. The nucleic acid and soluble protein contents were significantly released from the conidia of A. alternata after treatment with GcEO. Using SEM (scanning electron microscopy), morphological alterations were observed in the conidia, which indicates that a lesion in the cytoplasmic membrane is one of its mechanisms of action. Overall, these results indicate that GcEO is an antimicrobial agent with potential applications in the agriculture, food, and pharmaceutical industries.engElsevierBiological ProductsOils, VolatileCitronellalCitronellolConcentração inibitóriaProdutos naturaisIntegridade da membranaÓleos voláteisCitronellalCitronellolInhibitory concentrationNatural productsMembrane integrityVolatile oilsProdutos BiológicosÓleos VoláteisUntargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora duckeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55141/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza, Diego Pereira de - Untargeted metabolomics used to describe the chemical.pdfSouza, Diego Pereira de - Untargeted metabolomics used to describe the chemical.pdfapplication/pdf2438839https://www.arca.fiocruz.br/bitstream/icict/55141/2/Souza%2c%20Diego%20Pereira%20de%20%20-%20Untargeted%20metabolomics%20used%20to%20describe%20the%20chemical.pdfb21464832661b2720d4d4b5e84d53058MD52icict/551412023-03-15 14:32:51.984oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:51Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.en_US.fl_str_mv |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| title |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| spellingShingle |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke Souza, Diego Pereira de Biological Products Oils, Volatile Citronellal Citronellol Concentração inibitória Produtos naturais Integridade da membrana Óleos voláteis Citronellal Citronellol Inhibitory concentration Natural products Membrane integrity Volatile oils Produtos Biológicos Óleos Voláteis |
| title_short |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| title_full |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| title_fullStr |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| title_full_unstemmed |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| title_sort |
Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora ducke |
| author |
Souza, Diego Pereira de |
| author_facet |
Souza, Diego Pereira de Gonçalves, José Francisco de Carvalho Carvalho, Josiane Celerino de Silva, Karyne Kathlen Guedes da Fernandes, Andreia Varmes Nascimento, Gleisson de Oliveira Ramos, Marcio Viana Koolen, Hector Henrique Ferreira Bezerra, Daniel Pereira Santos, Alberdan Silva |
| author_role |
author |
| author2 |
Gonçalves, José Francisco de Carvalho Carvalho, Josiane Celerino de Silva, Karyne Kathlen Guedes da Fernandes, Andreia Varmes Nascimento, Gleisson de Oliveira Ramos, Marcio Viana Koolen, Hector Henrique Ferreira Bezerra, Daniel Pereira Santos, Alberdan Silva |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Diego Pereira de Gonçalves, José Francisco de Carvalho Carvalho, Josiane Celerino de Silva, Karyne Kathlen Guedes da Fernandes, Andreia Varmes Nascimento, Gleisson de Oliveira Ramos, Marcio Viana Koolen, Hector Henrique Ferreira Bezerra, Daniel Pereira Santos, Alberdan Silva |
| dc.subject.mesh.en_US.fl_str_mv |
Biological Products Oils, Volatile |
| topic |
Biological Products Oils, Volatile Citronellal Citronellol Concentração inibitória Produtos naturais Integridade da membrana Óleos voláteis Citronellal Citronellol Inhibitory concentration Natural products Membrane integrity Volatile oils Produtos Biológicos Óleos Voláteis |
| dc.subject.other.en_US.fl_str_mv |
Citronellal Citronellol Concentração inibitória Produtos naturais Integridade da membrana Óleos voláteis |
| dc.subject.en.en_US.fl_str_mv |
Citronellal Citronellol Inhibitory concentration Natural products Membrane integrity Volatile oils |
| dc.subject.decs.en_US.fl_str_mv |
Produtos Biológicos Óleos Voláteis |
| description |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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2022 |
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2022-10-14T15:29:15Z |
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2022-10-14T15:29:15Z |
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2022 |
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SOUZA, Diego Pereira de et al. Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora Ducke. Industrial Crops & Products, v. 186, p. 1-11, 2022. |
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https://www.arca.fiocruz.br/handle/icict/55141 |
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1872-633X |
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10.1016/j.indcrop.2022.115180 |
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SOUZA, Diego Pereira de et al. Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora Ducke. Industrial Crops & Products, v. 186, p. 1-11, 2022. 1872-633X 10.1016/j.indcrop.2022.115180 |
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