Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1111/cea.12399 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26526 |
Resumo: | Barreto, Mauricio Lima. Fiundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Endara, P.Vaca, M.Platts-Mills, T. A. E.Workman, L.Chico, M. E.Barreto, Maurício LimaRodrigues, Laura CunhaCooper, P. J.2018-05-21T17:16:49Z2018-05-21T17:16:49Z2015ENDARA, P. et al. Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. Clinical & Experimental Allergy, v. 45, p. 438-447, 2015.0954-7894https://www.arca.fiocruz.br/handle/icict/2652610.1111/cea.12399Barreto, Mauricio Lima. Fiundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Wellcome Trust, UK, HCPC Latin America Centres of Excellence Programme (grant 072405/Z/03/Z); PJC is supported by the Wellcome Trust (grant 088862/Z/09/Z); and TAEPM is supported by NIH grant AI-20565.Colegio de Ciencias de la Salud. Universidad San Francisco de Quito. Quito, Ecuador / Laboratorio de Investigaciones FEPIS. Quininde, Ecuador.Laboratorio de Investigaciones FEPIS. Quininde, Ecuador.University of Virginia. Asthma and Allergic Diseases Center. Charlottesville, VA, USA.University of Virginia. Asthma and Allergic Diseases Center. Charlottesville, VA, USA.Laboratorio de Investigaciones FEPIS. Quininde, Ecuador.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. London, UK.Colegio de Ciencias de la Salud. Universidad San Francisco de Quito. Quito, Ecuador / Laboratorio de Investigaciones FEPIS. Quininde, Ecuador / Pontificia Universidad Cat olica del Ecuador. Centro de investigacion en Enfermedades Infecciosas. Quito, Ecuador / St George’s University of London. Institute of Infection and Immunity. London.The association between atopy and asthma is attenuated in non-affluent populations, an effect that may be explained by childhood infections such as geohelminths. Objective To investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association. Methods We performed nested case–control studies among comparable populations of schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas, Ecuador. We detected geohelminths in stool samples, measured recent wheeze and environmental exposures by parental questionnaire, and atopy by specific IgE (sIgE) and skin prick test (SPT) reactivity to aeroallergens. Results Atopy, particularly sIgE to house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren: (urban, adj. OR 5.19, 95% CI 3.37–8.00, P < 0.0001; rural, adj. OR 1.81, 95%CI 1.09–2.99, P = 0.02; interaction, P < 0.001). The population fractions of wheeze attributable to atopy were approximately two-fold greater in urban schoolchildren: SPT to any allergen (urban 23.5% vs. rural 10.1%), SPT to HDM (urban 18.5% vs. rural 9.6%), and anti-HDM IgE (urban 26.5% vs. rural 10.5%), while anti-Ascaris IgE was related to wheeze in a high proportion of rural (49.7%) and urban (35.4%) children. The association between atopy and recent wheeze was attenuated by markers of geohelminth infections. Conclusions Our data suggest that urban residence modifies the association between HDM atopy and recent wheeze, and this effect is explained partly by geohelminth infections.engWileyAtopiaGeohelmintosÁcaro da poeira domiciliarAmérica LatinaTrópicosUrbanoChiadoAtopyGeohelminthsHouse dust miteLatin AmericaTropicsUrbanWheezeEffect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26526/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEndara P Effect of urban....pdfEndara P Effect of 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| dc.title.pt_BR.fl_str_mv |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| title |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| spellingShingle |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis Endara, P. Atopia Geohelmintos Ácaro da poeira domiciliar América Latina Trópicos Urbano Chiado Atopy Geohelminths House dust mite Latin America Tropics Urban Wheeze |
| title_short |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| title_full |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| title_fullStr |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| title_full_unstemmed |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| title_sort |
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis |
| author |
Endara, P. |
| author_facet |
Endara, P. Vaca, M. Platts-Mills, T. A. E. Workman, L. Chico, M. E. Barreto, Maurício Lima Rodrigues, Laura Cunha Cooper, P. J. |
| author_role |
author |
| author2 |
Vaca, M. Platts-Mills, T. A. E. Workman, L. Chico, M. E. Barreto, Maurício Lima Rodrigues, Laura Cunha Cooper, P. J. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Endara, P. Vaca, M. Platts-Mills, T. A. E. Workman, L. Chico, M. E. Barreto, Maurício Lima Rodrigues, Laura Cunha Cooper, P. J. |
| dc.subject.other.pt_BR.fl_str_mv |
Atopia Geohelmintos Ácaro da poeira domiciliar América Latina Trópicos Urbano Chiado |
| topic |
Atopia Geohelmintos Ácaro da poeira domiciliar América Latina Trópicos Urbano Chiado Atopy Geohelminths House dust mite Latin America Tropics Urban Wheeze |
| dc.subject.en.pt_BR.fl_str_mv |
Atopy Geohelminths House dust mite Latin America Tropics Urban Wheeze |
| description |
Barreto, Mauricio Lima. Fiundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2015 |
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2015 |
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ENDARA, P. et al. Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. Clinical & Experimental Allergy, v. 45, p. 438-447, 2015. |
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0954-7894 |
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10.1111/cea.12399 |
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ENDARA, P. et al. Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. Clinical & Experimental Allergy, v. 45, p. 438-447, 2015. 0954-7894 10.1111/cea.12399 |
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