Effects of maternal geohelminth infections on allergy in early childhood
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.jaci.2015.07.044 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20478 |
Resumo: | Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Cooper, Philip JChico, Martha EAmorim, Leila Denise Alves FerreiraSandoval, CarlosVaca, MaritzaStrina, AgostinoCampos, Ana Clara PaixãoRodrigues, Laura CunhaBarreto, Maurício LimaStrachan, David P2017-08-01T13:40:06Z2017-08-01T13:40:06Z2016COOPER, P. J. et al. Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, v. 137, p. 899-906, 2016.0091-6749https://www.arca.fiocruz.br/handle/icict/2047810.1016/j.jaci.2015.07.044Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Wellcome Trust grant 088862/Z/09/Z.Laboratorio de Investigaciones FEPIS. Quininde / Pontificia Universidad Catolica del Ecuador. Centro de Investigacion en Enfermedades Infecciosas. Quito, Ecuador / Institutes of Infection and Immunity. Quito, EcuadorLaboratorio de Investigaciones FEPIS. QuinindeUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilLaboratorio de Investigaciones FEPIS. QuinindeLaboratorio de Investigaciones FEPIS. QuinindeUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilLondon School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, WCUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilSt George’s University of London. Public Health Sciences. London, WCMaternal geohelminth infections during pregnancy may protect against allergy development in childhood. Objective: We sought to investigate the effect of maternal geohelminths on the development of eczema, wheeze, and atopy during the first 3 years of life. Methods: A cohort of 2404 neonates was followed to 3 years of age in a rural district in coastal Ecuador. Data on wheeze and eczema were collected by means of questionnaire and physical examination at 13, 24, and 36 months of age. Atopy was measured based on skin prick test (SPT) reactivity to 9 allergens at 36 months. Maternal stool samples were examined for geohelminths by microscopy. Data on potential confounders was collected after birth by questionnaire. Results: Geohelminths were observed in 45.9% of mothers. Eczema and wheeze were reported for 17.7% and 25.9%, respectively, of 2069 (86.1%) children with complete follow-up to 3 years, and allergen SPT reactivity to any allergen was present in 17.2% and to house dust mite in 8.7%. Maternal geohelminth infections were not significantly associated with eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61), wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61- 1.01). In subgroup analyses maternal geohelminths were associated with a significantly reduced risk of SPT reactivity to mite and other perennial allergens, and maternal ascariasis was associated with an increased risk of eczema and reduced risk of SPT reactivity to all allergens. Conclusion: Our data do not support a protective effect of maternal infections with geohelminth parasites during pregnancy against the development of eczema and wheeze in early childhood, although there was evidence in subgroup analyses for a reduction in SPT reactivity to house dust mites and perennial allergens.engAmerican Academy of Allergy, Asthma and ImmunologyGeohelmintosInfecções maternasAtopiaSibilânciaEczemaInfânciaGeohelminthsMaternal infectionsAtopyWheezeEczemaEarly childhoodEffects of maternal geohelminth infections on allergy in early childhoodinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20478/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCooper PJ Effects of maternal....pdfCooper PJ Effects of 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| dc.title.pt_BR.fl_str_mv |
Effects of maternal geohelminth infections on allergy in early childhood |
| title |
Effects of maternal geohelminth infections on allergy in early childhood |
| spellingShingle |
Effects of maternal geohelminth infections on allergy in early childhood Cooper, Philip J Geohelmintos Infecções maternas Atopia Sibilância Eczema Infância Geohelminths Maternal infections Atopy Wheeze Eczema Early childhood |
| title_short |
Effects of maternal geohelminth infections on allergy in early childhood |
| title_full |
Effects of maternal geohelminth infections on allergy in early childhood |
| title_fullStr |
Effects of maternal geohelminth infections on allergy in early childhood |
| title_full_unstemmed |
Effects of maternal geohelminth infections on allergy in early childhood |
| title_sort |
Effects of maternal geohelminth infections on allergy in early childhood |
| author |
Cooper, Philip J |
| author_facet |
Cooper, Philip J Chico, Martha E Amorim, Leila Denise Alves Ferreira Sandoval, Carlos Vaca, Maritza Strina, Agostino Campos, Ana Clara Paixão Rodrigues, Laura Cunha Barreto, Maurício Lima Strachan, David P |
| author_role |
author |
| author2 |
Chico, Martha E Amorim, Leila Denise Alves Ferreira Sandoval, Carlos Vaca, Maritza Strina, Agostino Campos, Ana Clara Paixão Rodrigues, Laura Cunha Barreto, Maurício Lima Strachan, David P |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cooper, Philip J Chico, Martha E Amorim, Leila Denise Alves Ferreira Sandoval, Carlos Vaca, Maritza Strina, Agostino Campos, Ana Clara Paixão Rodrigues, Laura Cunha Barreto, Maurício Lima Strachan, David P |
| dc.subject.other.pt_BR.fl_str_mv |
Geohelmintos Infecções maternas Atopia Sibilância Eczema Infância |
| topic |
Geohelmintos Infecções maternas Atopia Sibilância Eczema Infância Geohelminths Maternal infections Atopy Wheeze Eczema Early childhood |
| dc.subject.en.pt_BR.fl_str_mv |
Geohelminths Maternal infections Atopy Wheeze Eczema Early childhood |
| description |
Barreto, Mauricio Lima “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2016 |
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2016 |
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2017-08-01T13:40:06Z |
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2017-08-01T13:40:06Z |
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COOPER, P. J. et al. Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, v. 137, p. 899-906, 2016. |
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https://www.arca.fiocruz.br/handle/icict/20478 |
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0091-6749 |
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10.1016/j.jaci.2015.07.044 |
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COOPER, P. J. et al. Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, v. 137, p. 899-906, 2016. 0091-6749 10.1016/j.jaci.2015.07.044 |
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American Academy of Allergy, Asthma and Immunology |
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American Academy of Allergy, Asthma and Immunology |
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