Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease

Avelar, Renato Sathler; Avelar, Danielle Marquete Vitelli; Barbosa, Armanda Moreira Mattoso; Oliveira, Marcelo Perdigão de; Costa, Ronaldo Peres; Santos, Silvana Maria Elói; Gomes, Matheus de Souza; Amaral, Laurence Rodrigues do; Carvalho, Andréa Teixeira de; Martins Filho, Olindo Assis; Dick Junior, Edward J.; Hubbard, Gene B.; VandeBerg, Jane F.; VandeBerg, John L.

Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease

Detalhes bibliográficos
Autor(a) principal:	Avelar, Renato Sathler
Data de Publicação:	2016
Outros Autores:	Avelar, Danielle Marquete Vitelli, Barbosa, Armanda Moreira Mattoso, Oliveira, Marcelo Perdigão de, Costa, Ronaldo Peres, Santos, Silvana Maria Elói, Gomes, Matheus de Souza, Amaral, Laurence Rodrigues do, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Dick Junior, Edward J., Hubbard, Gene B., VandeBerg, Jane F., VandeBerg, John L.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/14852
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, Brazil/Centro Universitário Newton Paiva. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil/Texas Biomedical Research Institute. San Antonio, TX, United States of America

Metadados do item

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spelling	Avelar, Renato SathlerAvelar, Danielle Marquete VitelliBarbosa, Armanda Moreira MattosoOliveira, Marcelo Perdigão deCosta, Ronaldo PeresSantos, Silvana Maria ElóiGomes, Matheus de SouzaAmaral, Laurence Rodrigues doCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisDick Junior, Edward J.Hubbard, Gene B.VandeBerg, Jane F.VandeBerg, John L.2016-07-13T16:45:28Z2016-07-13T16:45:28Z2016AVELAR, Renato Sathler et al. Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease. PLoS Negl Trop Dis. Vol. 10, n. 1, p. e0004302, 2016.1935-2735https://www.arca.fiocruz.br/handle/icict/1485210.1371/journal.pntd.0004302. eCollection 2016engPublic Library of SciencePhenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, Brazil/Centro Universitário Newton Paiva. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil/Texas Biomedical Research Institute. San Antonio, TX, United States of AmericaFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, Brazil/Texas Biomedical Research Institute. San Antonio, TX, United States of America/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, Brazil/Centro Universitário Newton Paiva. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, Brazil/Centro Universitário Newton Paiva. Belo Horizonte, MG, BrasilCentro Universitário Newton Paiva. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedêutica Complementar. Belo Horizonte, MG, BrasilLaboratório de Bioinformática e Análise Molecular, Instituto de Genética e Bioquímica Universidade Federal de Uberlândia, Campus Patos de Minas, Patos de Minas, Minas Gerais, BrazilUniversidade Federal de Uberlândia. Faculdade de Ciência da Computação. Laboratório de Bioinformática e Análise Molecular. Patos de Minas, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, BrasilTexas Biomedical Research Institute. San Antonio, TX, United States of AmericaTexas Biomedical Research Institute. San Antonio, TX, United States of AmericaTexas Biomedical Research Institute. San Antonio, TX, United States of America/University of Texas Health Science Center. South Texas Diabetes and Obesity Institute. San Antonio – Regional Academic Health Center. Edinburg, TX, United States of AmericaTexas Biomedical Research Institute. San Antonio, TX, United States of America/University of Texas Health Science Center. South Texas Diabetes and Obesity Institute. San Antonio – Regional Academic Health Center. Edinburg, TX, United States of AmericaBACKGROUND: Cynomolgus macaques (Macaca fascicularis) represent a feasible model for research on Chagas disease since natural T. cruzi infection in these primates leads to clinical outcomes similar to those observed in humans. However, it is still unknown whether these clinical similarities are accompanied by equivalent immunological characteristics in the two species. We have performed a detailed immunophenotypic analysis of circulating leukocytes together with systems biology approaches from 15 cynomolgus macaques naturally infected with T. cruzi (CH) presenting the chronic phase of Chagas disease to identify biomarkers that might be useful for clinical investigations. METHODS AND FINDINGS: Our data established that CH displayed increased expression of CD32+ and CD56+ in monocytes and enhanced frequency of NK Granzyme A+ cells as compared to non-infected controls (NI). Moreover, higher expression of CD54 and HLA-DR by T-cells, especially within the CD8+ subset, was the hallmark of CH. A high level of expression of Granzyme A and Perforin underscored the enhanced cytotoxicity-linked pattern of CD8+ T-lymphocytes from CH. Increased frequency of B-cells with up-regulated expression of Fc-γRII was also observed in CH. Complex and imbricate biomarker networks demonstrated that CH showed a shift towards cross-talk among cells of the adaptive immune system. Systems biology analysis further established monocytes and NK-cell phenotypes and the T-cell activation status, along with the Granzyme A expression by CD8+ T-cells, as the most reliable biomarkers of potential use for clinical applications. CONCLUSIONS: Altogether, these findings demonstrated that the similarities in phenotypic features of circulating leukocytes observed in cynomolgus macaques and humans infected with T. cruzi further supports the use of these monkeys in preclinical toxicology and pharmacology studies applied to development and testing of new drugs for Chagas disease.B-Lymphocytes/immunologyCD8-Positive T-Lymphocytes/immunologyChagas Disease/immunologyChagas Disease/parasitologyDisease Models, AnimalKiller Cells, Natural/immunologyTrypanosoma cruzi/physiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
title	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
spellingShingle	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease Avelar, Renato Sathler B-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Chagas Disease/immunology Chagas Disease/parasitology Disease Models, Animal Killer Cells, Natural/immunology Trypanosoma cruzi/physiology
title_short	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
title_full	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
title_fullStr	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
title_full_unstemmed	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
title_sort	Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease
author	Avelar, Renato Sathler
author_facet	Avelar, Renato Sathler Avelar, Danielle Marquete Vitelli Barbosa, Armanda Moreira Mattoso Oliveira, Marcelo Perdigão de Costa, Ronaldo Peres Santos, Silvana Maria Elói Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Dick Junior, Edward J. Hubbard, Gene B. VandeBerg, Jane F. VandeBerg, John L.
author_role	author
author2	Avelar, Danielle Marquete Vitelli Barbosa, Armanda Moreira Mattoso Oliveira, Marcelo Perdigão de Costa, Ronaldo Peres Santos, Silvana Maria Elói Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Dick Junior, Edward J. Hubbard, Gene B. VandeBerg, Jane F. VandeBerg, John L.
author2_role	author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Avelar, Renato Sathler Avelar, Danielle Marquete Vitelli Barbosa, Armanda Moreira Mattoso Oliveira, Marcelo Perdigão de Costa, Ronaldo Peres Santos, Silvana Maria Elói Gomes, Matheus de Souza Amaral, Laurence Rodrigues do Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Dick Junior, Edward J. Hubbard, Gene B. VandeBerg, Jane F. VandeBerg, John L.
dc.subject.en.pt_BR.fl_str_mv	B-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Chagas Disease/immunology Chagas Disease/parasitology Disease Models, Animal Killer Cells, Natural/immunology Trypanosoma cruzi/physiology
topic	B-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Chagas Disease/immunology Chagas Disease/parasitology Disease Models, Animal Killer Cells, Natural/immunology Trypanosoma cruzi/physiology
description	Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, Minas Gerais, Brazil/Centro Universitário Newton Paiva. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil/Texas Biomedical Research Institute. San Antonio, TX, United States of America
publishDate	2016
dc.date.accessioned.fl_str_mv	2016-07-13T16:45:28Z
dc.date.available.fl_str_mv	2016-07-13T16:45:28Z
dc.date.issued.fl_str_mv	2016
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	AVELAR, Renato Sathler et al. Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease. PLoS Negl Trop Dis. Vol. 10, n. 1, p. e0004302, 2016.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/14852
dc.identifier.issn.pt_BR.fl_str_mv	1935-2735
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pntd.0004302. eCollection 2016
identifier_str_mv	AVELAR, Renato Sathler et al. Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease. PLoS Negl Trop Dis. Vol. 10, n. 1, p. e0004302, 2016. 1935-2735 10.1371/journal.pntd.0004302. eCollection 2016
url	https://www.arca.fiocruz.br/handle/icict/14852
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/14852/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/14852/2/ve_Avelar_Renato_Phenotypic_CPqRR_2016.pdf https://www.arca.fiocruz.br/bitstream/icict/14852/3/ve_Avelar_Renato_Phenotypic_CPqRR_2016.pdf.txt
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Phenotypic Features of Circulating Leukocytes from Non-human Primates Naturally Infected with Trypanosoma cruzi Resemble the Major Immunological Findings Observed in Human Chagas Disease

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