Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease

Detalhes bibliográficos
Autor(a) principal: Araújo, Fernanda Fortes de
Data de Publicação: 2011
Outros Autores: Avelar, Danielle Marquete Vitelli, Carvalho, Andréa Teixeira, Antas, Paulo Renato Zuquim, Gomes, Juliana Assis Silva, Avelar, Renato Sathler, Rocha, Manoel Otávio da Costa, Santos, Silvana Maria Elói, Pinho, Rosa Teixeira, Oliveira, Rodrigo Corrêa, Martins Filho, Olindo Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8665
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
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spelling Araújo, Fernanda Fortes deAvelar, Danielle Marquete VitelliCarvalho, Andréa TeixeiraAntas, Paulo Renato ZuquimGomes, Juliana Assis SilvaAvelar, Renato SathlerRocha, Manoel Otávio da CostaSantos, Silvana Maria ElóiPinho, Rosa TeixeiraOliveira, Rodrigo CorrêaMartins Filho, Olindo Assis2014-10-23T11:51:24Z2014-10-23T11:51:24Z2011ARAÚJO, Fernanda Fortes de et al. Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease. PLOS Neglected Tropical Diseases, v. 5, n. 5, p. 1-8, 2011.1935-2727https://www.arca.fiocruz.br/handle/icict/866510.1371/journal.pntd.0000992engPublic Library of ScienceRegulatory T Cells Phenotype in Different Clinical Forms of Chagas Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.CD25High CD4+ regulatory T cells (Treg cells) have been described as key players in immune regulation, preventing infection-induced immune pathology and limiting collateral tissue damage caused by vigorous anti-parasite immune response. In this review, we summarize data obtained by the investigation of Treg cells in different clinical forms of Chagas’ disease. Ex vivo immunophenotyping of whole blood, as well as after stimulation with Trypanosoma cruzi antigens, demonstrated that individuals in the indeterminate (IND) clinical form of the disease have a higher frequency of Treg cells, suggesting that an expansion of those cells could be beneficial, possibly by limiting strong cytotoxic activity and tissue damage. Additional analysis demonstrated an activated status of Treg cells based on low expression of CD62L and high expression of CD40L, CD69, and CD54 by cells from all chagasic patients after T. cruzi antigenic stimulation. Moreover, there was an increase in the frequency of the population of Foxp3+ CD25HighCD4+cells that was also IL-10+ in the IND group, whereas in the cardiac (CARD) group, there was an increase in the percentage of Foxp3+ CD25High CD4+ cells that expressed CTLA-4. These data suggest that IL-10 produced by Treg cells is effective in controlling disease development in IND patients. However, in CARD patients, the same regulatory mechanism, mediated by IL-10 and CTLA-4 expression is unlikely to be sufficient to control the progression of the disease. These data suggest that Treg cells may play an important role in controlling the immune response in Chagas’ disease and the balance between regulatory and effector T cells may be important for the progression and development of the disease. Additional detailed analysis of the mechanisms on how these cells are activated and exert their function will certainly give insights for the rational design of procedure to achieve the appropriate balance between protection and pathology during parasite infections.Chagas Disease/immunologyChagas Disease/pathologyT-Lymphocytes, Regulatory/chemistryTrypanosoma cruzi/immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8665/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALRegulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease.pdfRegulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease.pdfapplication/pdf527121https://www.arca.fiocruz.br/bitstream/icict/8665/2/Regulatory%20T%20Cells%20Phenotype%20in%20Different%20Clinical%20Forms%20of%20Chagas%20Disease.pdf9df851852637f12f4f3a6dd2c9984685MD52TEXTRegulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease.pdf.txtRegulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease.pdf.txtExtracted texttext/plain45683https://www.arca.fiocruz.br/bitstream/icict/8665/3/Regulatory%20T%20Cells%20Phenotype%20in%20Different%20Clinical%20Forms%20of%20Chagas%20Disease.pdf.txt8e05b875ed06d523743aa3b7c53d45f2MD53icict/86652023-09-05 10:15:30.06oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:15:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
title Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
spellingShingle Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
Araújo, Fernanda Fortes de
Chagas Disease/immunology
Chagas Disease/pathology
T-Lymphocytes, Regulatory/chemistry
Trypanosoma cruzi/immunology
title_short Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
title_full Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
title_fullStr Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
title_full_unstemmed Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
title_sort Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease
author Araújo, Fernanda Fortes de
author_facet Araújo, Fernanda Fortes de
Avelar, Danielle Marquete Vitelli
Carvalho, Andréa Teixeira
Antas, Paulo Renato Zuquim
Gomes, Juliana Assis Silva
Avelar, Renato Sathler
Rocha, Manoel Otávio da Costa
Santos, Silvana Maria Elói
Pinho, Rosa Teixeira
Oliveira, Rodrigo Corrêa
Martins Filho, Olindo Assis
author_role author
author2 Avelar, Danielle Marquete Vitelli
Carvalho, Andréa Teixeira
Antas, Paulo Renato Zuquim
Gomes, Juliana Assis Silva
Avelar, Renato Sathler
Rocha, Manoel Otávio da Costa
Santos, Silvana Maria Elói
Pinho, Rosa Teixeira
Oliveira, Rodrigo Corrêa
Martins Filho, Olindo Assis
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Fernanda Fortes de
Avelar, Danielle Marquete Vitelli
Carvalho, Andréa Teixeira
Antas, Paulo Renato Zuquim
Gomes, Juliana Assis Silva
Avelar, Renato Sathler
Rocha, Manoel Otávio da Costa
Santos, Silvana Maria Elói
Pinho, Rosa Teixeira
Oliveira, Rodrigo Corrêa
Martins Filho, Olindo Assis
dc.subject.en.pt_BR.fl_str_mv Chagas Disease/immunology
Chagas Disease/pathology
T-Lymphocytes, Regulatory/chemistry
Trypanosoma cruzi/immunology
topic Chagas Disease/immunology
Chagas Disease/pathology
T-Lymphocytes, Regulatory/chemistry
Trypanosoma cruzi/immunology
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-10-23T11:51:24Z
dc.date.available.fl_str_mv 2014-10-23T11:51:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, Fernanda Fortes de et al. Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease. PLOS Neglected Tropical Diseases, v. 5, n. 5, p. 1-8, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8665
dc.identifier.issn.none.fl_str_mv 1935-2727
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pntd.0000992
identifier_str_mv ARAÚJO, Fernanda Fortes de et al. Regulatory T Cells Phenotype in Different Clinical Forms of Chagas Disease. PLOS Neglected Tropical Diseases, v. 5, n. 5, p. 1-8, 2011.
1935-2727
10.1371/journal.pntd.0000992
url https://www.arca.fiocruz.br/handle/icict/8665
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/8665/1/license.txt
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