Characterization and trypanocidal activity of a β-lapachone-containing drug carrier
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46880 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Barbosa, Juliana M. C.Nicoletti, Caroline D.Silva, Patrícia B. daMelo, Tatiana G.Futuro, Débora O.Ferreira, Vitor F.Salomão, Kelly2021-04-25T19:20:00Z2021-04-25T19:20:00Z2021BARBOSA, Juliana M. C. et al. Characterization and trypanocidal activity of a β-lapachone-containing drug carrier. Plos One, v. 16, n. 3, p. 1-13, Mar. 2021.1932-6203https://www.arca.fiocruz.br/handle/icict/4688010.1371/journal.pone.0246811engPublic Library of ScienceAtividade tripanocidaCarreador de drogaβ-lapachonaCaracterizaçãoTrypanocidal activityCharacterizationβ-lapachoneContaining drug carrierCharacterization and trypanocidal activity of a β-lapachone-containing drug carrierinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Química. Laboratório de Síntese Orgânica Aplicada. Niterói. RJ, Brasil / Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular,. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Química. Laboratório de Síntese Orgânica Aplicada. Niterói. RJ, BrasilUniversidade Federal Fluminense. Instituto de Química. Laboratório de Síntese Orgânica Aplicada. Niterói. RJ, Brasil / Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.he treatment of Chagas disease (CD), a neglected parasitic condition caused by Trypano soma cruzi, is still based on only two drugs, nifurtimox (Nif) and benznidazole (Bz), both of which have limited efficacy in the late chronic phase and induce severe side effects. This scenario justifies the continuous search for alternative drugs, and in this context, the natural naphthoquinone β-lapachone (β-Lap) and its derivatives have demonstrated important try panocidal activities. Unfortunately, the decrease in trypanocidal activity in the blood, high toxicity to mammalian cells and low water solubility of β-Lap limit its systemic administration and, consequently, clinical applications. For this reason, carriers as drug delivery systems can strategically maximize the therapeutic effects of this drug, overcoming the above men tioned restrictions. Accordingly, the aim of this study is to investigate the in vitro anti-T. cruzi effects of β-Lap encapsulated in2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) and its poten tial toxicity to mammalian cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46880/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJulianaBarbosa_KellySalomao_etal_IOC_2021.pdfJulianaBarbosa_KellySalomao_etal_IOC_2021.pdfapplication/pdf1631700https://www.arca.fiocruz.br/bitstream/icict/46880/2/JulianaBarbosa_KellySalomao_etal_IOC_2021.pdf1429488c9f42a9f5c2d80406dd808423MD52TEXTJulianaBarbosa_KellySalomao_etal_IOC_2021.pdf.txtJulianaBarbosa_KellySalomao_etal_IOC_2021.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| title |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| spellingShingle |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier Barbosa, Juliana M. C. Atividade tripanocida Carreador de droga β-lapachona Caracterização Trypanocidal activity Characterization β-lapachone Containing drug carrier |
| title_short |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| title_full |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| title_fullStr |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| title_full_unstemmed |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| title_sort |
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier |
| author |
Barbosa, Juliana M. C. |
| author_facet |
Barbosa, Juliana M. C. Nicoletti, Caroline D. Silva, Patrícia B. da Melo, Tatiana G. Futuro, Débora O. Ferreira, Vitor F. Salomão, Kelly |
| author_role |
author |
| author2 |
Nicoletti, Caroline D. Silva, Patrícia B. da Melo, Tatiana G. Futuro, Débora O. Ferreira, Vitor F. Salomão, Kelly |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Barbosa, Juliana M. C. Nicoletti, Caroline D. Silva, Patrícia B. da Melo, Tatiana G. Futuro, Débora O. Ferreira, Vitor F. Salomão, Kelly |
| dc.subject.other.pt_BR.fl_str_mv |
Atividade tripanocida Carreador de droga β-lapachona Caracterização |
| topic |
Atividade tripanocida Carreador de droga β-lapachona Caracterização Trypanocidal activity Characterization β-lapachone Containing drug carrier |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanocidal activity Characterization β-lapachone Containing drug carrier |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2021 |
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2021-04-25T19:20:00Z |
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2021-04-25T19:20:00Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BARBOSA, Juliana M. C. et al. Characterization and trypanocidal activity of a β-lapachone-containing drug carrier. Plos One, v. 16, n. 3, p. 1-13, Mar. 2021. |
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https://www.arca.fiocruz.br/handle/icict/46880 |
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1932-6203 |
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10.1371/journal.pone.0246811 |
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BARBOSA, Juliana M. C. et al. Characterization and trypanocidal activity of a β-lapachone-containing drug carrier. Plos One, v. 16, n. 3, p. 1-13, Mar. 2021. 1932-6203 10.1371/journal.pone.0246811 |
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