Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study

Detalhes bibliográficos
Autor(a) principal: Erber, Astrid C.
Data de Publicação: 2020
Outros Autores: Arana, Byron, Salah, Afif Ben, Bennis, Issam, Boukthir, Aicha, Noriega, María Del Mar Castro, Cissé, Mamoudou, Cota, Gláucia Fernandes, Handjani, Farhad, López-Carvajal, Liliana, Marsh, Kevin, Medina, Dalila Martínez, Plugge, Emma, Lang, Trudie, Olliaro, Piero
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58483
Resumo: Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom/Department of Epidemiology. Center for Public Health. Medical University of Vienna.Vienna. Austria.
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spelling Erber, Astrid C.Arana, ByronSalah, Afif BenBennis, IssamBoukthir, AichaNoriega, María Del Mar CastroCissé, MamoudouCota, Gláucia FernandesHandjani, FarhadLópez-Carvajal, LilianaMarsh, KevinMedina, Dalila MartínezPlugge, EmmaLang, TrudieOlliaro, Piero2023-05-18T16:48:01Z2023-05-18T16:48:01Z2020ERBE, Astrid C et al. Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study. PLoS Negl Trop Dis., v. 14, n. 2, e0007996, 2020. doi: 10.1371/journal.pntd.0007996.1935-2735https://www.arca.fiocruz.br/handle/icict/5848310.1371/journal.pntd.0007996engPublic Library of SciencePatients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom/Department of Epidemiology. Center for Public Health. Medical University of Vienna.Vienna. Austria.Drugs for Neglected Diseases Initiative. Geneva, Switzerland.Institut Pasteur de Tunis. Tunis, Tunisia/Department of Family and Community Medicine. College of Medicine and Medical Sciences. Arabian Gulf University. Manama, Bahrain.National School of Public Health. Rabat, Morocco/Department of Public Health. Institute of Tropical Medicine. Antwerp, Belgium.Institut Pasteur de Tunis. Tunis, Tunisia.Centro Internacional de Entrenamiento de Investigaciones Médicas. Cali, Colombia/Universidad Icesi, Cali, Colombia.Centre MURAZ. Bobo-Dioulasso, Burkina Faso.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Molecular Dermatology Research Center. Shiraz University of Medical Sciences. Shiraz, Iran.Programa de Estudio y Control de Enfermedades Tropicales. Universidad de Antioquia. Medellín, Colombia.Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom.Facultad de Medicina "Alberto Hurtado". Universidad Peruana Cayetano Heredia. Lima, Perú/Departamento de Enfermedades Infecciosas, Dermatológicas y Tropicales. Hospital Cayetano Heredia. Lima, Perú.Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom/UK Collaborating Centre for the WHO Health in Prisons Programme. Public Health England. Reading, United Kingdom.Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom.Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom/Special Programme for Research & Training in Tropical Diseases. Geneva, Switzerland.Background Cutaneous leishmaniasis (CL) is a disease that often affects exposed skin areas and may heal leaving lifelong scars. Patients' expectations from treatment are rarely considered in drug development for CL. An initiative aiming to address shortcomings in clinical trial design and conduct for CL treatments involving the researchers' community is on-going. This manuscript presents patient-preferred outcomes for CL and an assessment on how to consider these in the conduct of future trials. Methodology/Principal findings We report preferred treatment outcomes by 74 patients with confirmed CL in endemic regions of Brazil, Burkina Faso, Colombia, Iran, Morocco, Peru and Tunisia during individual in-depth interviews. Beyond outcomes customarily considered in trials (such as lesion appearance and adverse events), patients talked about a large number of outcomes related to quality of life, such as pain, scar formation, and others affecting their work and daily activities. They also reported fears around getting rid of the parasite, disease recurrence, and possible sequelae. Author summary Cutaneous Leishmaniasis (CL) is a parasitic disease transmitted by sand fly vectors causing lesions and potentially life-long scars. Trials for CL treatments so far have not included patients' input, such as their preferences on outcomes. This study reports treatment outcomes seen as important by patients that were explored through semi-structured interviews conducted in CL-endemic regions in Brazil, Burkina Faso, Colombia, Iran, Morocco, Peru and Tunisia. In addition to outcomes mostly considered in trials centered on lesion evolution and adverse events, patients reported a wide range of further outcomes and concerns. These are related to their quality of life, but also parasitological cure, potential for recurrence and sequelae of the disease. We suggest possibilities on how to include and measure a number of these patient-preferred outcomes into trials, and discuss ways of considering others in the context of treatment and clinical trials, e.g. via information provided to patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPatients' preferences of cutaneous leishmaniasis treatment outcomes.pdfPatients' preferences of cutaneous leishmaniasis treatment outcomes.pdfapplication/pdf1041340https://www.arca.fiocruz.br/bitstream/icict/58483/2/Patients%27%20preferences%20of%20cutaneous%20leishmaniasis%20treatment%20outcomes.pdf440ec36d4890d057805a3ea79d3ecbabMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58483/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584832023-05-18 13:48:03.371oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-18T16:48:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
title Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
spellingShingle Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
Erber, Astrid C.
title_short Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
title_full Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
title_fullStr Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
title_full_unstemmed Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
title_sort Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
author Erber, Astrid C.
author_facet Erber, Astrid C.
Arana, Byron
Salah, Afif Ben
Bennis, Issam
Boukthir, Aicha
Noriega, María Del Mar Castro
Cissé, Mamoudou
Cota, Gláucia Fernandes
Handjani, Farhad
López-Carvajal, Liliana
Marsh, Kevin
Medina, Dalila Martínez
Plugge, Emma
Lang, Trudie
Olliaro, Piero
author_role author
author2 Arana, Byron
Salah, Afif Ben
Bennis, Issam
Boukthir, Aicha
Noriega, María Del Mar Castro
Cissé, Mamoudou
Cota, Gláucia Fernandes
Handjani, Farhad
López-Carvajal, Liliana
Marsh, Kevin
Medina, Dalila Martínez
Plugge, Emma
Lang, Trudie
Olliaro, Piero
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Erber, Astrid C.
Arana, Byron
Salah, Afif Ben
Bennis, Issam
Boukthir, Aicha
Noriega, María Del Mar Castro
Cissé, Mamoudou
Cota, Gláucia Fernandes
Handjani, Farhad
López-Carvajal, Liliana
Marsh, Kevin
Medina, Dalila Martínez
Plugge, Emma
Lang, Trudie
Olliaro, Piero
description Nuffield Department of Medicine. Centre for Tropical Medicine and Global Health. University of Oxford. Oxford, United Kingdom/Department of Epidemiology. Center for Public Health. Medical University of Vienna.Vienna. Austria.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2023-05-18T16:48:01Z
dc.date.available.fl_str_mv 2023-05-18T16:48:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ERBE, Astrid C et al. Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study. PLoS Negl Trop Dis., v. 14, n. 2, e0007996, 2020. doi: 10.1371/journal.pntd.0007996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58483
dc.identifier.issn.en_US.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007996
identifier_str_mv ERBE, Astrid C et al. Patients' preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study. PLoS Negl Trop Dis., v. 14, n. 2, e0007996, 2020. doi: 10.1371/journal.pntd.0007996.
1935-2735
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dc.language.iso.fl_str_mv eng
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