Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Camila Sampaio
Data de Publicação: 2021
Outros Autores: França, Riam Rocha, Silva, Juliana Almeida, Silva, Silvana Conceição da, Uliana, Silvia Reni Bortolin, Boaventura, Viviane Sampaio, Machado, Paulo Roberto Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48963
Resumo: Funaderm--- Fundo de Apoio à Dermatologia.
id CRUZ_ab78636a24431d0aaa0cac38ef0cc635
oai_identifier_str oai:www.arca.fiocruz.br:icict/48963
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Ribeiro, Camila SampaioFrança, Riam RochaSilva, Juliana AlmeidaSilva, Silvana Conceição daUliana, Silvia Reni BortolinBoaventura, Viviane SampaioMachado, Paulo Roberto Lima2021-09-03T19:18:39Z2021-09-03T19:18:39Z2021RIBEIRO, Camila Sampaio et al. Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome. Anais Brasileiros de Dermatologia, p. 1-7, 28 July 2021.0365-0596https://www.arca.fiocruz.br/handle/icict/4896310.1016/j.abd.2021.02.0061806-4841Funaderm--- Fundo de Apoio à Dermatologia.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. Laboratório de Leishmanioses. São Paulo, SP, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Background: The treatment of cutaneous leishmaniasis is a challenge. A better understanding of the in situ mechanisms involved in the evolution and cure of the disease is essential for the development of new therapies. Objective: Correlate histopathological and immunological characteristics of cutaneous leishmaniasis lesions with clinical outcome after different treatment regimens. Methods: The authors analyzed cellular infiltration and immunohistochemistry staining for CD4, CD8 and IL-17 in biopsy samples from 33 patients with cutaneous leishmaniasis before treatment. All patients were recruited in a randomized clinical trial at Corte de Pedra (Bahia-Brazil) and assigned to receive Glucantime®, Glucantime® + Oral Tamoxifen or Glucantime® + Topical Tamoxifen. Patients were followed for 2 to 6 months to define disease outcome. Results: A similar expression of CD4, CD8 and IL-17 was observed in lesion samples regardless of clinical outcome. In general, a higher amount of CD8 cells were observed compared with CD4 cells. An important observation was that all patients whose cellular infiltrate did not contain plasma cells were cured after treatment. Study limitations: Isolated quantification of TCD8 and IL-17 using immunohistochemistry is insufficient to analyze the role of these molecules in the immunopathogenesis of cutaneous leishmaniasis. In addition, the expansion of the immunohistochemistry panel would allow a more complete analysis of the immune response in situ. Conclusions: The absence of plasma cells in cutaneous leishmaniasis lesions was related to a favorable therapeutic outcome.engSociedade Brasileira de DermatologiaAntígenos CD4Antígenos CD8ImunohistoquímicaInterleucina-17Leishmaniose cutâneaPlasmaCD4 antigensCD8 antigensImmunohistochemistryInterleukin-17Leishmaniasis, cutaneousPlasma cellsCellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcomeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48963/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALRibeiro, Camila Sampaio Cellular....pdfRibeiro, Camila Sampaio Cellular....pdfapplication/pdf1576553https://www.arca.fiocruz.br/bitstream/icict/48963/2/Ribeiro%2c%20Camila%20Sampaio%20Cellular....pdf615d08c5522475d2904f1a5fe773ba6eMD52TEXTRibeiro, Camila Sampaio Cellular....pdf.txtRibeiro, Camila Sampaio Cellular....pdf.txtExtracted texttext/plain26015https://www.arca.fiocruz.br/bitstream/icict/48963/3/Ribeiro%2c%20Camila%20Sampaio%20Cellular....pdf.txt2a72b77625442488f566e9c90f6dcaf6MD53icict/489632023-03-15 14:34:28.341oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:28Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en.fl_str_mv Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
title Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
spellingShingle Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
Ribeiro, Camila Sampaio
Antígenos CD4
Antígenos CD8
Imunohistoquímica
Interleucina-17
Leishmaniose cutânea
Plasma
CD4 antigens
CD8 antigens
Immunohistochemistry
Interleukin-17
Leishmaniasis, cutaneous
Plasma cells
title_short Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
title_full Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
title_fullStr Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
title_full_unstemmed Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
title_sort Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome
author Ribeiro, Camila Sampaio
author_facet Ribeiro, Camila Sampaio
França, Riam Rocha
Silva, Juliana Almeida
Silva, Silvana Conceição da
Uliana, Silvia Reni Bortolin
Boaventura, Viviane Sampaio
Machado, Paulo Roberto Lima
author_role author
author2 França, Riam Rocha
Silva, Juliana Almeida
Silva, Silvana Conceição da
Uliana, Silvia Reni Bortolin
Boaventura, Viviane Sampaio
Machado, Paulo Roberto Lima
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Camila Sampaio
França, Riam Rocha
Silva, Juliana Almeida
Silva, Silvana Conceição da
Uliana, Silvia Reni Bortolin
Boaventura, Viviane Sampaio
Machado, Paulo Roberto Lima
dc.subject.other.pt_BR.fl_str_mv Antígenos CD4
Antígenos CD8
Imunohistoquímica
Interleucina-17
Leishmaniose cutânea
Plasma
topic Antígenos CD4
Antígenos CD8
Imunohistoquímica
Interleucina-17
Leishmaniose cutânea
Plasma
CD4 antigens
CD8 antigens
Immunohistochemistry
Interleukin-17
Leishmaniasis, cutaneous
Plasma cells
dc.subject.en.pt_BR.fl_str_mv CD4 antigens
CD8 antigens
Immunohistochemistry
Interleukin-17
Leishmaniasis, cutaneous
Plasma cells
description Funaderm--- Fundo de Apoio à Dermatologia.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-03T19:18:39Z
dc.date.available.fl_str_mv 2021-09-03T19:18:39Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO, Camila Sampaio et al. Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome. Anais Brasileiros de Dermatologia, p. 1-7, 28 July 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48963
dc.identifier.issn.pt_BR.fl_str_mv 0365-0596
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.abd.2021.02.006
dc.identifier.eissn.pt_BR.fl_str_mv 1806-4841
identifier_str_mv RIBEIRO, Camila Sampaio et al. Cellular infiltrate in cutaneous leishmaniasis lesionsand therapeutic outcome. Anais Brasileiros de Dermatologia, p. 1-7, 28 July 2021.
0365-0596
10.1016/j.abd.2021.02.006
1806-4841
url https://www.arca.fiocruz.br/handle/icict/48963
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48963/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/48963/2/Ribeiro%2c%20Camila%20Sampaio%20Cellular....pdf
https://www.arca.fiocruz.br/bitstream/icict/48963/3/Ribeiro%2c%20Camila%20Sampaio%20Cellular....pdf.txt
bitstream.checksum.fl_str_mv 36b51ef91c52b5338d9d29ba0cc807bc
615d08c5522475d2904f1a5fe773ba6e
2a72b77625442488f566e9c90f6dcaf6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009192961703936

Registros relacionados