Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Macedo, Priscila Marques de; Paes, Rodrigo Almeida; Almeida, Marcos de Abreu; Coelho, Rowena Alves; Oliveira Filho, Marcio Amaral de; Medeiros, Denise Machado; Silva, Adriano Gomes; Lima, Jéssica Ribeiro de; Cruz, Alda Maria da; Zancopé-Oliveira, Rosely Maria; Valle, Antonio Carlos Francesconi do

Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Detalhes bibliográficos
Autor(a) principal:	Macedo, Priscila Marques de
Data de Publicação:	2018
Outros Autores:	Paes, Rodrigo Almeida, Almeida, Marcos de Abreu, Coelho, Rowena Alves, Oliveira Filho, Marcio Amaral de, Medeiros, Denise Machado, Silva, Adriano Gomes, Lima, Jéssica Ribeiro de, Cruz, Alda Maria da, Zancopé-Oliveira, Rosely Maria, Valle, Antonio Carlos Francesconi do
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/31363
Resumo:	Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.

Metadados do item

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spelling	Macedo, Priscila Marques dePaes, Rodrigo AlmeidaAlmeida, Marcos de AbreuCoelho, Rowena AlvesOliveira Filho, Marcio Amaral deMedeiros, Denise MachadoSilva, Adriano GomesLima, Jéssica Ribeiro deCruz, Alda Maria daZancopé-Oliveira, Rosely MariaValle, Antonio Carlos Francesconi do2019-01-31T15:38:43Z2019-01-31T15:38:43Z2018MACEDO, Priscila Marques de et al. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 111-114, Jan./Feb. 2018.0037-8682https://www.arca.fiocruz.br/handle/icict/3136310.1590/0037-8682-0318-20171678-9849engSociedade Brasileira de Medicina TropicalParacoccidioides brasiliensis S1Choque sépticoInteração parasita-hospedeiroParacoccidioides brasiliensis S1Septic shockHost-parasite interactionFatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31363/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjessicaR_lima_etal_IOC_2018.pdfjessicaR_lima_etal_IOC_2018.pdfapplication/pdf1592300https://www.arca.fiocruz.br/bitstream/icict/31363/2/jessicaR_lima_etal_IOC_2018.pdfe37e95450872afd75af0ec6711008788MD52TEXTjessicaR_lima_etal_IOC_2018.pdf.txtjessicaR_lima_etal_IOC_2018.pdf.txtExtracted texttext/plain16183https://www.arca.fiocruz.br/bitstream/icict/31363/3/jessicaR_lima_etal_IOC_2018.pdf.txt227f8311606874ded8b1d4d3e2e0e327MD53icict/313632023-10-25 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dc.title.pt_BR.fl_str_mv	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
spellingShingle	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report Macedo, Priscila Marques de Paracoccidioides brasiliensis S1 Choque séptico Interação parasita-hospedeiro Paracoccidioides brasiliensis S1 Septic shock Host-parasite interaction
title_short	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_full	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_fullStr	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_full_unstemmed	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_sort	Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
author	Macedo, Priscila Marques de
author_facet	Macedo, Priscila Marques de Paes, Rodrigo Almeida Almeida, Marcos de Abreu Coelho, Rowena Alves Oliveira Filho, Marcio Amaral de Medeiros, Denise Machado Silva, Adriano Gomes Lima, Jéssica Ribeiro de Cruz, Alda Maria da Zancopé-Oliveira, Rosely Maria Valle, Antonio Carlos Francesconi do
author_role	author
author2	Paes, Rodrigo Almeida Almeida, Marcos de Abreu Coelho, Rowena Alves Oliveira Filho, Marcio Amaral de Medeiros, Denise Machado Silva, Adriano Gomes Lima, Jéssica Ribeiro de Cruz, Alda Maria da Zancopé-Oliveira, Rosely Maria Valle, Antonio Carlos Francesconi do
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Macedo, Priscila Marques de Paes, Rodrigo Almeida Almeida, Marcos de Abreu Coelho, Rowena Alves Oliveira Filho, Marcio Amaral de Medeiros, Denise Machado Silva, Adriano Gomes Lima, Jéssica Ribeiro de Cruz, Alda Maria da Zancopé-Oliveira, Rosely Maria Valle, Antonio Carlos Francesconi do
dc.subject.other.pt_BR.fl_str_mv	Paracoccidioides brasiliensis S1 Choque séptico Interação parasita-hospedeiro
topic	Paracoccidioides brasiliensis S1 Choque séptico Interação parasita-hospedeiro Paracoccidioides brasiliensis S1 Septic shock Host-parasite interaction
dc.subject.en.pt_BR.fl_str_mv	Paracoccidioides brasiliensis S1 Septic shock Host-parasite interaction
description	Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.
publishDate	2018
dc.date.issued.fl_str_mv	2018
dc.date.accessioned.fl_str_mv	2019-01-31T15:38:43Z
dc.date.available.fl_str_mv	2019-01-31T15:38:43Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MACEDO, Priscila Marques de et al. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 111-114, Jan./Feb. 2018.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/31363
dc.identifier.issn.pt_BR.fl_str_mv	0037-8682
dc.identifier.doi.none.fl_str_mv	10.1590/0037-8682-0318-2017
dc.identifier.eissn.none.fl_str_mv	1678-9849
identifier_str_mv	MACEDO, Priscila Marques de et al. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 111-114, Jan./Feb. 2018. 0037-8682 10.1590/0037-8682-0318-2017 1678-9849
url	https://www.arca.fiocruz.br/handle/icict/31363
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv	Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

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