Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Detalhes bibliográficos
Autor(a) principal: Macedo, Priscila Marques de
Data de Publicação: 2018
Outros Autores: Paes, Rodrigo Almeida, Almeida, Marcos de Abreu, Coelho, Rowena Alves, Oliveira Filho, Marcio Amaral de, Medeiros, Denise Machado, Silva, Adriano Gomes, Lima, Jéssica Ribeiro de, Cruz, Alda Maria da, Zancopé-Oliveira, Rosely Maria, Valle, Antonio Carlos Francesconi do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0037-8682-0318-2017
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31363
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.
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spelling Macedo, Priscila Marques dePaes, Rodrigo AlmeidaAlmeida, Marcos de AbreuCoelho, Rowena AlvesOliveira Filho, Marcio Amaral deMedeiros, Denise MachadoSilva, Adriano GomesLima, Jéssica Ribeiro deCruz, Alda Maria daZancopé-Oliveira, Rosely MariaValle, Antonio Carlos Francesconi do2019-01-31T15:38:43Z2019-01-31T15:38:43Z2018MACEDO, Priscila Marques de et al. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 111-114, Jan./Feb. 2018.0037-8682https://www.arca.fiocruz.br/handle/icict/3136310.1590/0037-8682-0318-20171678-9849engSociedade Brasileira de Medicina TropicalParacoccidioides brasiliensis S1Choque sépticoInteração parasita-hospedeiroParacoccidioides brasiliensis S1Septic shockHost-parasite interactionFatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31363/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjessicaR_lima_etal_IOC_2018.pdfjessicaR_lima_etal_IOC_2018.pdfapplication/pdf1592300https://www.arca.fiocruz.br/bitstream/icict/31363/2/jessicaR_lima_etal_IOC_2018.pdfe37e95450872afd75af0ec6711008788MD52TEXTjessicaR_lima_etal_IOC_2018.pdf.txtjessicaR_lima_etal_IOC_2018.pdf.txtExtracted texttext/plain16183https://www.arca.fiocruz.br/bitstream/icict/31363/3/jessicaR_lima_etal_IOC_2018.pdf.txt227f8311606874ded8b1d4d3e2e0e327MD53icict/313632023-10-25 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dc.title.pt_BR.fl_str_mv Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
spellingShingle Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
Macedo, Priscila Marques de
Paracoccidioides brasiliensis S1
Choque séptico
Interação parasita-hospedeiro
Paracoccidioides brasiliensis S1
Septic shock
Host-parasite interaction
title_short Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_full Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_fullStr Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_full_unstemmed Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_sort Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
author Macedo, Priscila Marques de
author_facet Macedo, Priscila Marques de
Paes, Rodrigo Almeida
Almeida, Marcos de Abreu
Coelho, Rowena Alves
Oliveira Filho, Marcio Amaral de
Medeiros, Denise Machado
Silva, Adriano Gomes
Lima, Jéssica Ribeiro de
Cruz, Alda Maria da
Zancopé-Oliveira, Rosely Maria
Valle, Antonio Carlos Francesconi do
author_role author
author2 Paes, Rodrigo Almeida
Almeida, Marcos de Abreu
Coelho, Rowena Alves
Oliveira Filho, Marcio Amaral de
Medeiros, Denise Machado
Silva, Adriano Gomes
Lima, Jéssica Ribeiro de
Cruz, Alda Maria da
Zancopé-Oliveira, Rosely Maria
Valle, Antonio Carlos Francesconi do
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo, Priscila Marques de
Paes, Rodrigo Almeida
Almeida, Marcos de Abreu
Coelho, Rowena Alves
Oliveira Filho, Marcio Amaral de
Medeiros, Denise Machado
Silva, Adriano Gomes
Lima, Jéssica Ribeiro de
Cruz, Alda Maria da
Zancopé-Oliveira, Rosely Maria
Valle, Antonio Carlos Francesconi do
dc.subject.other.pt_BR.fl_str_mv Paracoccidioides brasiliensis S1
Choque séptico
Interação parasita-hospedeiro
topic Paracoccidioides brasiliensis S1
Choque séptico
Interação parasita-hospedeiro
Paracoccidioides brasiliensis S1
Septic shock
Host-parasite interaction
dc.subject.en.pt_BR.fl_str_mv Paracoccidioides brasiliensis S1
Septic shock
Host-parasite interaction
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-31T15:38:43Z
dc.date.available.fl_str_mv 2019-01-31T15:38:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO, Priscila Marques de et al. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 111-114, Jan./Feb. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31363
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0318-2017
dc.identifier.eissn.none.fl_str_mv 1678-9849
identifier_str_mv MACEDO, Priscila Marques de et al. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 111-114, Jan./Feb. 2018.
0037-8682
10.1590/0037-8682-0318-2017
1678-9849
url https://www.arca.fiocruz.br/handle/icict/31363
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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