Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Detalhes bibliográficos
Autor(a) principal: Macedo,Priscila Marques de
Data de Publicação: 2018
Outros Autores: Almeida-Paes,Rodrigo, Almeida,Marcos de Abreu, Coelho,Rowena Alves, Oliveira Filho,Marcio Amaral de, Medeiros,Denise Machado, Gomes-Silva,Adriano, Lima,Jéssica Ribeiro de, Da-Cruz,Alda Maria, Zancopé-Oliveira,Rosely Maria, Valle,Antonio Carlos Francesconi do
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000100111
Resumo: Abstract The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.
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spelling Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case reportParacoccidioides brasiliensis S1Septic shockHost-parasite interactionAbstract The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.Sociedade Brasileira de Medicina Tropical - SBMT2018-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000100111Revista da Sociedade Brasileira de Medicina Tropical v.51 n.1 2018reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0318-2017info:eu-repo/semantics/openAccessMacedo,Priscila Marques deAlmeida-Paes,RodrigoAlmeida,Marcos de AbreuCoelho,Rowena AlvesOliveira Filho,Marcio Amaral deMedeiros,Denise MachadoGomes-Silva,AdrianoLima,Jéssica Ribeiro deDa-Cruz,Alda MariaZancopé-Oliveira,Rosely MariaValle,Antonio Carlos Francesconi doeng2018-06-05T00:00:00Zoai:scielo:S0037-86822018000100111Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2018-06-05T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
spellingShingle Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
Macedo,Priscila Marques de
Paracoccidioides brasiliensis S1
Septic shock
Host-parasite interaction
title_short Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_full Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_fullStr Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_full_unstemmed Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
title_sort Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report
author Macedo,Priscila Marques de
author_facet Macedo,Priscila Marques de
Almeida-Paes,Rodrigo
Almeida,Marcos de Abreu
Coelho,Rowena Alves
Oliveira Filho,Marcio Amaral de
Medeiros,Denise Machado
Gomes-Silva,Adriano
Lima,Jéssica Ribeiro de
Da-Cruz,Alda Maria
Zancopé-Oliveira,Rosely Maria
Valle,Antonio Carlos Francesconi do
author_role author
author2 Almeida-Paes,Rodrigo
Almeida,Marcos de Abreu
Coelho,Rowena Alves
Oliveira Filho,Marcio Amaral de
Medeiros,Denise Machado
Gomes-Silva,Adriano
Lima,Jéssica Ribeiro de
Da-Cruz,Alda Maria
Zancopé-Oliveira,Rosely Maria
Valle,Antonio Carlos Francesconi do
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo,Priscila Marques de
Almeida-Paes,Rodrigo
Almeida,Marcos de Abreu
Coelho,Rowena Alves
Oliveira Filho,Marcio Amaral de
Medeiros,Denise Machado
Gomes-Silva,Adriano
Lima,Jéssica Ribeiro de
Da-Cruz,Alda Maria
Zancopé-Oliveira,Rosely Maria
Valle,Antonio Carlos Francesconi do
dc.subject.por.fl_str_mv Paracoccidioides brasiliensis S1
Septic shock
Host-parasite interaction
topic Paracoccidioides brasiliensis S1
Septic shock
Host-parasite interaction
description Abstract The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000100111
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000100111
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-0318-2017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.51 n.1 2018
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
institution SBMT
reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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