Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis

Detalhes bibliográficos
Autor(a) principal: Massana, Arnau Casanovas
Data de Publicação: 2021
Outros Autores: Oliveira, Daiana de, Schneider, Andrew G., Begon, Mike, Childs, James E., Costa, Federico, Reis, Mitermayer Galvão dos, Ko, Albert Icksang, Wunder Junior, Elsio Augusto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50066
Resumo: National Institutes of Health (grant numbers R01 AI052473, U01 AI088752, R25 TW009338, R01 TW009504, and R01 AI121207); and the Wellcome Trust (grant number 102330/Z/13/Z).
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spelling Massana, Arnau CasanovasOliveira, Daiana deSchneider, Andrew G.Begon, MikeChilds, James E.Costa, FedericoReis, Mitermayer Galvão dosKo, Albert IcksangWunder Junior, Elsio Augusto2021-11-25T18:04:02Z2021-11-25T18:04:02Z2021MASSANA, Arnau Casanovas et al. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal of Infectious Diseases, 2021.0022-1899https://www.arca.fiocruz.br/handle/icict/5006610.1093/infdis/jiab323National Institutes of Health (grant numbers R01 AI052473, U01 AI088752, R25 TW009338, R01 TW009504, and R01 AI121207); and the Wellcome Trust (grant number 102330/Z/13/Z).Yale School of Public Health. New Haven, Connecticut, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Yale School of Public Health. New Haven, Connecticut, USA.Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom,Yale School of Public Health. New Haven, Connecticut, USA.Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / 4Universidade Federal da Bahia, Salvador, Bahia, Brazil.Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Yale School of Public Health. New Haven, Connecticut, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.In this study, we genotyped samples from environmental reservoirs (surface water and soil), colonized rat specimens, and cases of human severe leptospirosis from an endemic urban slum in Brazil, to determine the molecular epidemiology of pathogenic Leptospira and identify pathways of leptospirosis infection. We identified a well-established population of Leptospira interrogans serovar Copenhageni common to human leptospirosis cases, and animal and environmental reservoirs. This finding provides genetic evidence for a potential environmental spillover pathway for rat-borne leptospirosis through the environment in this urban community and highlights the importance of environmental and social interventions to reduce spillover infections.engOxford University PressReservatório ambientalLeptospira interrogansLeptospiroseLeptospiraRattus norvegicusGenotipagemSoloAguaEnvironmental reservoirLeptospira interrogansLeptospirosisPathogenic LeptospiraRattus norvegicusGenotypingSoilWater.Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50066/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALMassana, Arnau Casanovas Genetic....pdfMassana, Arnau Casanovas Genetic....pdfapplication/pdf227160https://www.arca.fiocruz.br/bitstream/icict/50066/2/Massana%2c%20Arnau%20Casanovas%20Genetic....pdfac19fe92f2915e040429daf556f49eacMD52icict/500662023-03-15 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dc.title.pt_BR.fl_str_mv Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
title Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
spellingShingle Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
Massana, Arnau Casanovas
Reservatório ambiental
Leptospira interrogans
Leptospirose
Leptospira
Rattus norvegicus
Genotipagem
Solo
Agua
Environmental reservoir
Leptospira interrogans
Leptospirosis
Pathogenic Leptospira
Rattus norvegicus
Genotyping
Soil
Water.
title_short Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
title_full Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
title_fullStr Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
title_full_unstemmed Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
title_sort Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis
author Massana, Arnau Casanovas
author_facet Massana, Arnau Casanovas
Oliveira, Daiana de
Schneider, Andrew G.
Begon, Mike
Childs, James E.
Costa, Federico
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Wunder Junior, Elsio Augusto
author_role author
author2 Oliveira, Daiana de
Schneider, Andrew G.
Begon, Mike
Childs, James E.
Costa, Federico
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Wunder Junior, Elsio Augusto
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Massana, Arnau Casanovas
Oliveira, Daiana de
Schneider, Andrew G.
Begon, Mike
Childs, James E.
Costa, Federico
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Wunder Junior, Elsio Augusto
dc.subject.other.pt_BR.fl_str_mv Reservatório ambiental
Leptospira interrogans
Leptospirose
Leptospira
Rattus norvegicus
Genotipagem
Solo
Agua
topic Reservatório ambiental
Leptospira interrogans
Leptospirose
Leptospira
Rattus norvegicus
Genotipagem
Solo
Agua
Environmental reservoir
Leptospira interrogans
Leptospirosis
Pathogenic Leptospira
Rattus norvegicus
Genotyping
Soil
Water.
dc.subject.en.pt_BR.fl_str_mv Environmental reservoir
Leptospira interrogans
Leptospirosis
Pathogenic Leptospira
Rattus norvegicus
Genotyping
Soil
Water.
description National Institutes of Health (grant numbers R01 AI052473, U01 AI088752, R25 TW009338, R01 TW009504, and R01 AI121207); and the Wellcome Trust (grant number 102330/Z/13/Z).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-25T18:04:02Z
dc.date.available.fl_str_mv 2021-11-25T18:04:02Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MASSANA, Arnau Casanovas et al. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal of Infectious Diseases, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50066
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jiab323
identifier_str_mv MASSANA, Arnau Casanovas et al. Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis. The Journal of Infectious Diseases, 2021.
0022-1899
10.1093/infdis/jiab323
url https://www.arca.fiocruz.br/handle/icict/50066
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50066/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50066/2/Massana%2c%20Arnau%20Casanovas%20Genetic....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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