Zika virus damages the human placental barrier and presents marked fetal neurotropism

Detalhes bibliográficos
Autor(a) principal: Noronha, Lucia de
Data de Publicação: 2016
Outros Autores: Zanluca, Camila, Azevedo, Marina Luize Viola, Luz, Kleber Giovanni, Santos, Claudia Nunes Duarte dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: https://doi.org/10.1590/0074-02760160085
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14145
https://doi.org/10.1590/0074-02760160085
Resumo: Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.
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spelling Noronha, Lucia deZanluca, CamilaAzevedo, Marina Luize ViolaLuz, Kleber GiovanniSantos, Claudia Nunes Duarte dos2016-05-10T13:47:39Z2016-05-10T13:47:39Z2016NORONHA, Lucia de; ZANLUCA, Camila; AZEVEDO, Marina Luize Viola; LUZ, Kleber Giovanni; SANTOS, Claudia Nunes Duarte dos. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 5, p. 1-7, May 2016.1678-8060https://www.arca.fiocruz.br/handle/icict/14145https://doi.org/10.1590/0074-02760160085engFundação Oswaldo CruzVírus ZikaMicrocefaliaBrasilEpidemiaZika VirusTransplacental transmissionHofbauer cellsMarked fetal neurotropismMicrocephalyEpidemicZika virus damages the human placental barrier and presents marked fetal neurotropisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical. Natal, RN, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.An unusually high incidence of microcephaly in newborns has recently been observed in Brazil. There is a temporal association between the increase in cases of microcephaly and the Zika virus (ZIKV) epidemic. Viral RNA has been detected in amniotic fluid samples, placental tissues and newborn and fetal brain tissues. However, much remains to be determined concerning the association between ZIKV infection and fetal malformations. In this study, we provide evidence of the transplacental transmission of ZIKV through the detection of viral proteins and viral RNA in placental tissue samples from expectant mothers infected at different stages of gestation. We observed chronic placentitis (TORCH type) with viral protein detection by immunohistochemistry in Hofbauer cells and some histiocytes in the intervillous spaces. We also demonstrated the neurotropism of the virus via the detection of viral proteins in glial cells and in some endothelial cells and the observation of scattered foci of microcalcifications in the brain tissues. Lesions were mainly located in the white matter. ZIKV RNA was also detected in these tissues by real-time-polymerase chain reaction. We believe that these findings will contribute to the body of knowledge of the mechanisms of ZIKV transmission, interactions between the virus and host cells and viral tropism.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14145/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALZika virus damages the human placental barrier and presents marked fetal neurotropism.pdfZika virus damages the human placental barrier and presents marked fetal neurotropism.pdfapplication/pdf1105746https://www.arca.fiocruz.br/bitstream/icict/14145/2/Zika%20virus%20damages%20the%20human%20placental%20barrier%20and%20presents%20marked%20fetal%20neurotropism.pdfb1d12ab552d6ba6aa4d3f65652e5dd73MD52TEXTZika virus damages the human placental barrier and presents marked fetal neurotropism.pdf.txtZika virus damages the human placental barrier and presents marked fetal neurotropism.pdf.txtExtracted texttext/plain36970https://www.arca.fiocruz.br/bitstream/icict/14145/3/Zika%20virus%20damages%20the%20human%20placental%20barrier%20and%20presents%20marked%20fetal%20neurotropism.pdf.txt38124b99d76e3715dfeb17ec7b7726d4MD53icict/141452018-04-02 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dc.title.pt_BR.fl_str_mv Zika virus damages the human placental barrier and presents marked fetal neurotropism
title Zika virus damages the human placental barrier and presents marked fetal neurotropism
spellingShingle Zika virus damages the human placental barrier and presents marked fetal neurotropism
Noronha, Lucia de
Vírus Zika
Microcefalia
Brasil
Epidemia
Zika Virus
Transplacental transmission
Hofbauer cells
Marked fetal neurotropism
Microcephaly
Epidemic
title_short Zika virus damages the human placental barrier and presents marked fetal neurotropism
title_full Zika virus damages the human placental barrier and presents marked fetal neurotropism
title_fullStr Zika virus damages the human placental barrier and presents marked fetal neurotropism
title_full_unstemmed Zika virus damages the human placental barrier and presents marked fetal neurotropism
title_sort Zika virus damages the human placental barrier and presents marked fetal neurotropism
author Noronha, Lucia de
author_facet Noronha, Lucia de
Zanluca, Camila
Azevedo, Marina Luize Viola
Luz, Kleber Giovanni
Santos, Claudia Nunes Duarte dos
author_role author
author2 Zanluca, Camila
Azevedo, Marina Luize Viola
Luz, Kleber Giovanni
Santos, Claudia Nunes Duarte dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Noronha, Lucia de
Zanluca, Camila
Azevedo, Marina Luize Viola
Luz, Kleber Giovanni
Santos, Claudia Nunes Duarte dos
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Microcefalia
Brasil
Epidemia
topic Vírus Zika
Microcefalia
Brasil
Epidemia
Zika Virus
Transplacental transmission
Hofbauer cells
Marked fetal neurotropism
Microcephaly
Epidemic
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Transplacental transmission
Hofbauer cells
Marked fetal neurotropism
Microcephaly
Epidemic
description Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-05-10T13:47:39Z
dc.date.available.fl_str_mv 2016-05-10T13:47:39Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NORONHA, Lucia de; ZANLUCA, Camila; AZEVEDO, Marina Luize Viola; LUZ, Kleber Giovanni; SANTOS, Claudia Nunes Duarte dos. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 5, p. 1-7, May 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14145
dc.identifier.issn.none.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1590/0074-02760160085
identifier_str_mv NORONHA, Lucia de; ZANLUCA, Camila; AZEVEDO, Marina Luize Viola; LUZ, Kleber Giovanni; SANTOS, Claudia Nunes Duarte dos. Zika virus damages the human placental barrier and presents marked fetal neurotropism. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 111, n. 5, p. 1-7, May 2016.
1678-8060
url https://www.arca.fiocruz.br/handle/icict/14145
https://doi.org/10.1590/0074-02760160085
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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