Genetic and antigenic variability of HIV type 1 in Brazil

Detalhes bibliográficos
Autor(a) principal: Fernandez, José C. Couto
Data de Publicação: 1994
Outros Autores: Janssens, Wouter, Heyndrickx, Leo, Motte, Jan, Fransen, Katrien, Peeters, Martine, Delaporte, Eric, Castro Filho, Bernardo Galvão, Piot, Peter, van der Groen, Guido
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14933
Resumo: Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
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spelling Fernandez, José C. CoutoJanssens, WouterHeyndrickx, LeoMotte, JanFransen, KatrienPeeters, MartineDelaporte, EricCastro Filho, Bernardo GalvãoPiot, Petervan der Groen, Guido2016-07-15T16:53:26Z2016-07-15T16:53:26Z1994FERNANDEZ, J. C. C. et al. Genetic and antigenic variability of HIV type 1 in Brazil. AIDS Research and Human Retroviruses, v. 10, n. 9, p. 1157-1163, 1994.0889-2229https://www.arca.fiocruz.br/handle/icict/1493310.1089/aid.1994.10.1157engMary Ann LiebertGenetic and antigenic variability of HIV type 1 in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumINSERM U13. IMEA-Hôpital Bichat-Claude Bernard. Paris, FranceFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumInstitute of Tropical Medicine. Division of Microbiology. Department of Infection and Immunity. Antwerp, BelgiumSix Brazilian strains of human immunodeficiency virus type 1 (HIV-1) were isolated from infected individuals residing in different regions of Brazil between 1987 and 1989. Phylogenetic analysis based on an 860-base pair env fragment, including V3, V4, V5, and the beginning of gp41, classified the Brazilian strains significantly in genotype B, with interhost distances between 5.9 and 13.1% (mean value, 10%). Amino acid sequence analysis of the V3 loop revealed that three strains contained the North American/European GPGR motif as the tip of the loop whereas in the other three strains proline (P) was substituted by tryptophan (W), methionine (M), or phenylalanine (F). A consensus peptide, Bra-cons, was designed containing GWGR as the tip of the loop. Serological reactivity to the Bra-cons peptide and other V3 peptides (MN, SF2, HBX2, RF, MAL, ELI, Z6, and a Côte d'Ivoire peptide, CI-cons) was compared for 114 HIV-1-positive sera from Rio de Janeiro. Sixty-nine sera (60.5%) reacted with peptides belonging to genotype B, of which 10 sera also reacted with peptides belonging to genotype A (n = 7) and D (n = 3). Eighteen sera (15.8%) had binding antibodies to the Bra-cons peptide. A high number of sera (n = 43; 37.7%) had no antibodies to any of the V3 peptides tested. This result suggests that HIV-1 variants with aberrant V3 loops may circulate in Rio de Janeiro.HIV-1Antigenic VariationPhylogenyHIV AntibodiesGenotypeHIV InfectionsBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14933/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandez JCC Genetic and antigenic....pdfFernandez JCC Genetic and antigenic....pdfapplication/pdf1132381https://www.arca.fiocruz.br/bitstream/icict/14933/2/Fernandez%20JCC%20Genetic%20and%20antigenic....pdf6370b2247fbe22dfd514a5b84c9a620fMD52TEXTFernandez JCC Genetic and antigenic....pdf.txtFernandez JCC Genetic and antigenic....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Genetic and antigenic variability of HIV type 1 in Brazil
title Genetic and antigenic variability of HIV type 1 in Brazil
spellingShingle Genetic and antigenic variability of HIV type 1 in Brazil
Fernandez, José C. Couto
HIV-1
Antigenic Variation
Phylogeny
HIV Antibodies
Genotype
HIV Infections
Brazil
title_short Genetic and antigenic variability of HIV type 1 in Brazil
title_full Genetic and antigenic variability of HIV type 1 in Brazil
title_fullStr Genetic and antigenic variability of HIV type 1 in Brazil
title_full_unstemmed Genetic and antigenic variability of HIV type 1 in Brazil
title_sort Genetic and antigenic variability of HIV type 1 in Brazil
author Fernandez, José C. Couto
author_facet Fernandez, José C. Couto
Janssens, Wouter
Heyndrickx, Leo
Motte, Jan
Fransen, Katrien
Peeters, Martine
Delaporte, Eric
Castro Filho, Bernardo Galvão
Piot, Peter
van der Groen, Guido
author_role author
author2 Janssens, Wouter
Heyndrickx, Leo
Motte, Jan
Fransen, Katrien
Peeters, Martine
Delaporte, Eric
Castro Filho, Bernardo Galvão
Piot, Peter
van der Groen, Guido
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandez, José C. Couto
Janssens, Wouter
Heyndrickx, Leo
Motte, Jan
Fransen, Katrien
Peeters, Martine
Delaporte, Eric
Castro Filho, Bernardo Galvão
Piot, Peter
van der Groen, Guido
dc.subject.en.pt_BR.fl_str_mv HIV-1
Antigenic Variation
Phylogeny
HIV Antibodies
Genotype
HIV Infections
Brazil
topic HIV-1
Antigenic Variation
Phylogeny
HIV Antibodies
Genotype
HIV Infections
Brazil
description Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2016-07-15T16:53:26Z
dc.date.available.fl_str_mv 2016-07-15T16:53:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDEZ, J. C. C. et al. Genetic and antigenic variability of HIV type 1 in Brazil. AIDS Research and Human Retroviruses, v. 10, n. 9, p. 1157-1163, 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14933
dc.identifier.issn.pt_BR.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/aid.1994.10.1157
identifier_str_mv FERNANDEZ, J. C. C. et al. Genetic and antigenic variability of HIV type 1 in Brazil. AIDS Research and Human Retroviruses, v. 10, n. 9, p. 1157-1163, 1994.
0889-2229
10.1089/aid.1994.10.1157
url https://www.arca.fiocruz.br/handle/icict/14933
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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