Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes

Detalhes bibliográficos
Autor(a) principal: Monteiro, Joana Paixão
Data de Publicação: 2009
Outros Autores: Alcântara, Luiz Carlos Júnior, Oliveira, Tulio de, Oliveira, Antonio Marcos, Melo, Marco Antônio Gomes, Brites, Carlos, Castro, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13707
Resumo: Texto completo: acesso restrito. p. 391–399
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spelling Monteiro, Joana PaixãoAlcântara, Luiz Carlos JúniorOliveira, Tulio deOliveira, Antonio MarcosMelo, Marco Antônio GomesBrites, CarlosCastro, Bernardo GalvãoMonteiro, Joana PaixãoAlcântara, Luiz Carlos JúniorOliveira, Tulio deOliveira, Antonio MarcosMelo, Marco Antônio GomesBrites, CarlosCastro, Bernardo Galvão2013-11-18T20:52:34Z20090146-6615http://repositorio.ufba.br/ri/handle/ri/13707v. 81, n. 3Texto completo: acesso restrito. p. 391–399The HIV-1 genetic variability in Bahia state, Brazil, was investigated. DNA samples from 229 and 213 HIV-1-infected individuals were analyzed using the heteroduplex mobility assay (HMA) in gag and env fragments, respectively. One hundred seventy-five samples were characterized in both genes. Thirty-two subtype F and BF recombinant viruses were sequenced and analyzed by phylogenetic methods. The combination of HMA and sequencing results showed that seven different HIV-1 genotypes comprised this sample: 147 (84%) B/B, 4 (2.3%) F/F, 3 (1.7%) B/F, 1 (0.6%) F/B, 1 (0.6%) F/D, 1 (0.6%) BF/F, and 18 (10.3%) BF/B. A significant divergence was observed between these two techniques results (84.4%). This is explained by the low accuracy of the HMA for detecting recombinant viruses. These recombinants were unrelated to CRF12, while two sequences were related to CRF28 and CRF29. Nineteen BF mosaics shared the same gag breakpoint. In conclusion, the use of HMA may be inappropriate in regions where different subtypes are co-circulating. Subtype B is the most common genotype, however, an increased prevalence (13.1%) of different BF variants and a potentially new CRF suggest that recombination is occurring frequently in Bahia. These viruses were associated with women infected heterosexually. Finally, this study identified the presence of an F/D recombinant HIV-1 in Brazil.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-29T16:08:18Z No. of bitstreams: 1 21414_ftp.pdf: 269246 bytes, checksum: 37ce18cd263f9f02f477c37f23d310ec (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-18T20:52:34Z (GMT) No. of bitstreams: 1 21414_ftp.pdf: 269246 bytes, checksum: 37ce18cd263f9f02f477c37f23d310ec (MD5)Made available in DSpace on 2013-11-18T20:52:34Z (GMT). No. of bitstreams: 1 21414_ftp.pdf: 269246 bytes, checksum: 37ce18cd263f9f02f477c37f23d310ec (MD5) Previous issue date: 2009http://dx.doi.org/10.1002/jmv.21414reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIV-1EpidemiologyPhylogenyBrazilBahiaGenetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypesJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL21414_ftp.pdf21414_ftp.pdfapplication/pdf269246https://repositorio.ufba.br/bitstream/ri/13707/1/21414_ftp.pdf37ce18cd263f9f02f477c37f23d310ecMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13707/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT21414_ftp.pdf.txt21414_ftp.pdf.txtExtracted texttext/plain39310https://repositorio.ufba.br/bitstream/ri/13707/3/21414_ftp.pdf.txtef28d994dde7b4abc78e78e0f09cd8b3MD53ri/137072022-07-05 14:04:17.874oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
dc.title.alternative.pt_BR.fl_str_mv Journal of Medical Virology
title Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
spellingShingle Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
Monteiro, Joana Paixão
HIV-1
Epidemiology
Phylogeny
Brazil
Bahia
title_short Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
title_full Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
title_fullStr Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
title_full_unstemmed Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
title_sort Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
author Monteiro, Joana Paixão
author_facet Monteiro, Joana Paixão
Alcântara, Luiz Carlos Júnior
Oliveira, Tulio de
Oliveira, Antonio Marcos
Melo, Marco Antônio Gomes
Brites, Carlos
Castro, Bernardo Galvão
author_role author
author2 Alcântara, Luiz Carlos Júnior
Oliveira, Tulio de
Oliveira, Antonio Marcos
Melo, Marco Antônio Gomes
Brites, Carlos
Castro, Bernardo Galvão
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro, Joana Paixão
Alcântara, Luiz Carlos Júnior
Oliveira, Tulio de
Oliveira, Antonio Marcos
Melo, Marco Antônio Gomes
Brites, Carlos
Castro, Bernardo Galvão
Monteiro, Joana Paixão
Alcântara, Luiz Carlos Júnior
Oliveira, Tulio de
Oliveira, Antonio Marcos
Melo, Marco Antônio Gomes
Brites, Carlos
Castro, Bernardo Galvão
dc.subject.por.fl_str_mv HIV-1
Epidemiology
Phylogeny
Brazil
Bahia
topic HIV-1
Epidemiology
Phylogeny
Brazil
Bahia
description Texto completo: acesso restrito. p. 391–399
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-11-18T20:52:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13707
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v. 81, n. 3
identifier_str_mv 0146-6615
v. 81, n. 3
url http://repositorio.ufba.br/ri/handle/ri/13707
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1002/jmv.21414
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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