Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42541 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) and Research Program of Gonçalo Moniz Institut of Fiocruz-BA. (VMB). |
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Santos, Hayna MaltaCosta, Jaqueline FrançaMacedo, AmandaQueiroz, Artur Trancoso Lopo deFukutani, Kiyoshi FerreiraMuxel, Sandra MarciaCunha, Antonio Ricardo KhouriVan Weyenbergh, JohanBoaventura, VivianeBarral, Aldina Maria PradoCosta, Jackson MFloh, Eny Iochevet SegalAndrade, Bruno de BezerrilWinter, Lucile M FloeterBorges, Valéria Matos2020-08-05T11:57:29Z2020-08-05T11:57:29Z2020SANTOS, Hayna Malta et al. Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis. Scientific Reports, v. 10, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4254110.1038/s41598-020-67432-5Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) and Research Program of Gonçalo Moniz Institut of Fiocruz-BA. (VMB).Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédica. Departamento de Botânica. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil.Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, SP, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / University of Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Leuven, Belgium.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Maranhão. São Luis, MA, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Botânica. São Paulo, SP, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil.Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, SP, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Tegumentary leishmaniasis (TL) is a parasitic disease that can result in wide spectrum clinical manifestations. It is necessary to understand host and parasite determinants of clinical outcomes to identify novel therapeutic targets. Previous studies have indicated that the polyamine biosynthetic pathway is critical for Leishmania growth and survival. Despite its importance, expression of the such pathway has not been previously investigated in TL patients. We performed an exploratory analysis employing Systems Biology tools to compare circulating polyamines and amino acid concentration as well as polyamine pathway gene expression in cutaneous lesions patients presenting with distinct TL disease presentations. Diffuse cutaneous leishmaniasis (DCL) was associated with higher concentrations of amino acids, polyamines and its substrate transporters than mucosal cutaneous leishmaniasis or localized cutaneous leishmaniasis. In addition, the RNA expression of polyamine-related genes of patients lesions from two separate cohorts demonstrated that differential activation of this pathway is associated with parasite loads and able to discriminate the clinical spectrum of TL. Taken together, our findings highlight a new aspect of DCL immunopathogenesis indicating that the polyamine pathway may be explored as a novel therapeutic target to control disease burden.engNature ResearchLeishmaniose cutâneaLeishmaniose tegumentarPoliaminaAminoacidosLeishmaniasis CutaneousLeishmaniasis diffusePolyaminesAmino AcidsDifferential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42541/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos, Hayana Malta Differential....pdfSantos, Hayana Malta Differential....pdfapplication/pdf2576813https://www.arca.fiocruz.br/bitstream/icict/42541/2/Santos%2c%20Hayana%20Malta%20Differential....pdf477f4049490512016ce505fc24713febMD52TEXTSantos, Hayana Malta Differential....pdf.txtSantos, Hayana Malta Differential....pdf.txtExtracted texttext/plain57230https://www.arca.fiocruz.br/bitstream/icict/42541/3/Santos%2c%20Hayana%20Malta%20Differential....pdf.txt2c295a006d18632c5b107004411691bbMD53icict/425412023-03-15 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| dc.title.pt_BR.fl_str_mv |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| title |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| spellingShingle |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis Santos, Hayna Malta Leishmaniose cutânea Leishmaniose tegumentar Poliamina Aminoacidos Leishmaniasis Cutaneous Leishmaniasis diffuse Polyamines Amino Acids |
| title_short |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| title_full |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| title_fullStr |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| title_full_unstemmed |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| title_sort |
Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis |
| author |
Santos, Hayna Malta |
| author_facet |
Santos, Hayna Malta Costa, Jaqueline França Macedo, Amanda Queiroz, Artur Trancoso Lopo de Fukutani, Kiyoshi Ferreira Muxel, Sandra Marcia Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Boaventura, Viviane Barral, Aldina Maria Prado Costa, Jackson M Floh, Eny Iochevet Segal Andrade, Bruno de Bezerril Winter, Lucile M Floeter Borges, Valéria Matos |
| author_role |
author |
| author2 |
Costa, Jaqueline França Macedo, Amanda Queiroz, Artur Trancoso Lopo de Fukutani, Kiyoshi Ferreira Muxel, Sandra Marcia Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Boaventura, Viviane Barral, Aldina Maria Prado Costa, Jackson M Floh, Eny Iochevet Segal Andrade, Bruno de Bezerril Winter, Lucile M Floeter Borges, Valéria Matos |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Hayna Malta Costa, Jaqueline França Macedo, Amanda Queiroz, Artur Trancoso Lopo de Fukutani, Kiyoshi Ferreira Muxel, Sandra Marcia Cunha, Antonio Ricardo Khouri Van Weyenbergh, Johan Boaventura, Viviane Barral, Aldina Maria Prado Costa, Jackson M Floh, Eny Iochevet Segal Andrade, Bruno de Bezerril Winter, Lucile M Floeter Borges, Valéria Matos |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea Leishmaniose tegumentar Poliamina Aminoacidos |
| topic |
Leishmaniose cutânea Leishmaniose tegumentar Poliamina Aminoacidos Leishmaniasis Cutaneous Leishmaniasis diffuse Polyamines Amino Acids |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Cutaneous Leishmaniasis diffuse Polyamines Amino Acids |
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Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) and Research Program of Gonçalo Moniz Institut of Fiocruz-BA. (VMB). |
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2020 |
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2020-08-05T11:57:29Z |
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2020-08-05T11:57:29Z |
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2020 |
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info:eu-repo/semantics/article |
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SANTOS, Hayna Malta et al. Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis. Scientific Reports, v. 10, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42541 |
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2045-2322 |
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10.1038/s41598-020-67432-5 |
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SANTOS, Hayna Malta et al. Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis. Scientific Reports, v. 10, 2020. 2045-2322 10.1038/s41598-020-67432-5 |
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Nature Research |
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