Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58030 |
Resumo: | Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Recife, PE, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Centro de Ciências da Saúde, Recife, PE Brasil. Hospital Universitário Oswaldo Cruz, Unidade de Endocrinologia, Recife, PE, Brasil. Universidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brasil. Hospital Universitário Oswaldo Cruz, Departamento de Infectologia Pediátrica, Recife, PE, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Social, Recife, PE, Brasil. Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento Materno-Infantil, Recife, PE, Brasil. Fundação Altino Ventura, Departamento de Oftalmologia, Recife, PE, Brasil. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. Universidade de Pernambuco, Departamento de Medicina Interna, Recife, PE, Brasil. |
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Veras Gonçalves, AndréiaMiranda-Filho, Demócrito de B.Rocha Vilela, Líbia CristinaRamos, Regina Coeli Ferreirade Araújo, Thalia V. B.de Vasconcelos, Rômulo A. L.Wanderley Rocha, Maria AngelaEickmann, Sophie HelenaCordeiro, Marli TenórioVentura, Liana O.Montarroyos, Ulisses RamosMertens Brainer, AlessandraCosta Gomes, Maria Durceda Silva, Paula Fabiana SobralMartelli, Celina M. T.Brickley, Elizabeth B.Ximenes, Ricardo A. A.2023-04-27T13:43:56Z2023-04-27T13:43:56Z2020-12-22GONÇALVES, Andréia Veras; MIRANDA-FILHO, Demócrito de B.; VILELA, Líbia Cristina Rocha; RAMOS, Regina Coeli Ferreira; ARAðJO, Thalia V. B. de; VASCONCELOS, Rômulo A. L. de; ROCHA, Maria Angela Wanderley; EICKMANN, Sophie Helena; CORDEIRO, Marli Tenório; VENTURA, Liana O. et al. Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil. Viruses, [S.L.], v. 13, n. 1, p. 1-13, 22 dez. 2020. MDPI AG. http://dx.doi.org/10.3390/v13010001.1999-4915https://www.arca.fiocruz.br/handle/icict/58030porEndocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Instituto Aggeu Magalhães, Recife, PE, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Centro de Ciências da Saúde, Recife, PE Brasil. Hospital Universitário Oswaldo Cruz, Unidade de Endocrinologia, Recife, PE, Brasil. Universidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brasil. Hospital Universitário Oswaldo Cruz, Departamento de Infectologia Pediátrica, Recife, PE, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Social, Recife, PE, Brasil. Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento Materno-Infantil, Recife, PE, Brasil. Fundação Altino Ventura, Departamento de Oftalmologia, Recife, PE, Brasil. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. Universidade de Pernambuco, Departamento de Medicina Interna, Recife, PE, Brasil.Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary.microcephalZikaobesithypothyroidismpubertyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83088https://www.arca.fiocruz.br/bitstream/icict/58030/1/license.txt7b043faf2a6ad46e5344ca8d54801d8cMD51ORIGINALEndocrine Dysfunction in Children with Zika-Related.pdfEndocrine Dysfunction in Children with Zika-Related.pdfapplication/pdf309545https://www.arca.fiocruz.br/bitstream/icict/58030/3/Endocrine%20Dysfunction%20in%20Children%20with%20Zika-Related.pdfa799d6de4ebe90704d8d46f5d1e0e82fMD53icict/580302023-05-30 12:55:21.975oai:www.arca.fiocruz.br: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Repositório 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| dc.title.en_US.fl_str_mv |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| spellingShingle |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil Veras Gonçalves, Andréia microcephal Zika obesit hypothyroidism puberty |
| title_short |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_full |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_fullStr |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_full_unstemmed |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_sort |
Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| author |
Veras Gonçalves, Andréia |
| author_facet |
Veras Gonçalves, Andréia Miranda-Filho, Demócrito de B. Rocha Vilela, Líbia Cristina Ramos, Regina Coeli Ferreira de Araújo, Thalia V. B. de Vasconcelos, Rômulo A. L. Wanderley Rocha, Maria Angela Eickmann, Sophie Helena Cordeiro, Marli Tenório Ventura, Liana O. Montarroyos, Ulisses Ramos Mertens Brainer, Alessandra Costa Gomes, Maria Durce da Silva, Paula Fabiana Sobral Martelli, Celina M. T. Brickley, Elizabeth B. Ximenes, Ricardo A. A. |
| author_role |
author |
| author2 |
Miranda-Filho, Demócrito de B. Rocha Vilela, Líbia Cristina Ramos, Regina Coeli Ferreira de Araújo, Thalia V. B. de Vasconcelos, Rômulo A. L. Wanderley Rocha, Maria Angela Eickmann, Sophie Helena Cordeiro, Marli Tenório Ventura, Liana O. Montarroyos, Ulisses Ramos Mertens Brainer, Alessandra Costa Gomes, Maria Durce da Silva, Paula Fabiana Sobral Martelli, Celina M. T. Brickley, Elizabeth B. Ximenes, Ricardo A. A. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Veras Gonçalves, Andréia Miranda-Filho, Demócrito de B. Rocha Vilela, Líbia Cristina Ramos, Regina Coeli Ferreira de Araújo, Thalia V. B. de Vasconcelos, Rômulo A. L. Wanderley Rocha, Maria Angela Eickmann, Sophie Helena Cordeiro, Marli Tenório Ventura, Liana O. Montarroyos, Ulisses Ramos Mertens Brainer, Alessandra Costa Gomes, Maria Durce da Silva, Paula Fabiana Sobral Martelli, Celina M. T. Brickley, Elizabeth B. Ximenes, Ricardo A. A. |
| dc.subject.en.en_US.fl_str_mv |
microcephal Zika obesit hypothyroidism puberty |
| topic |
microcephal Zika obesit hypothyroidism puberty |
| description |
Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Recife, PE, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Centro de Ciências da Saúde, Recife, PE Brasil. Hospital Universitário Oswaldo Cruz, Unidade de Endocrinologia, Recife, PE, Brasil. Universidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brasil. Hospital Universitário Oswaldo Cruz, Departamento de Infectologia Pediátrica, Recife, PE, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Social, Recife, PE, Brasil. Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento Materno-Infantil, Recife, PE, Brasil. Fundação Altino Ventura, Departamento de Oftalmologia, Recife, PE, Brasil. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. Universidade de Pernambuco, Departamento de Medicina Interna, Recife, PE, Brasil. |
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2020 |
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2020-12-22 |
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2023-04-27T13:43:56Z |
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2023-04-27T13:43:56Z |
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GONÇALVES, Andréia Veras; MIRANDA-FILHO, Demócrito de B.; VILELA, Líbia Cristina Rocha; RAMOS, Regina Coeli Ferreira; ARAðJO, Thalia V. B. de; VASCONCELOS, Rômulo A. L. de; ROCHA, Maria Angela Wanderley; EICKMANN, Sophie Helena; CORDEIRO, Marli Tenório; VENTURA, Liana O. et al. Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil. Viruses, [S.L.], v. 13, n. 1, p. 1-13, 22 dez. 2020. MDPI AG. http://dx.doi.org/10.3390/v13010001. |
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1999-4915 |
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GONÇALVES, Andréia Veras; MIRANDA-FILHO, Demócrito de B.; VILELA, Líbia Cristina Rocha; RAMOS, Regina Coeli Ferreira; ARAðJO, Thalia V. B. de; VASCONCELOS, Rômulo A. L. de; ROCHA, Maria Angela Wanderley; EICKMANN, Sophie Helena; CORDEIRO, Marli Tenório; VENTURA, Liana O. et al. Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil. Viruses, [S.L.], v. 13, n. 1, p. 1-13, 22 dez. 2020. MDPI AG. http://dx.doi.org/10.3390/v13010001. 1999-4915 |
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