Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/S0074-02762012000200015 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15540 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. |
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Antunes, Sérgio Luiz GomesChimelli, LeilaJardim, Márcia RodriguesVital, Robson TeixeiraNery, José Augusto da CostaCorte-Real, SuzanaHacker, Mariana Andréa Vilas BoasSarno, Euzenir Nunes2016-08-30T15:54:39Z2016-08-30T15:54:39Z2012ANTUNES, Sérgio Luiz Gomes; et al. Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. Mem Inst Oswaldo Cruz, v.107, n.2, p. 246-253, Mar. 2012.1678-8060https://www.arca.fiocruz.br/handle/icict/1554010.1590/S0074-02762012000200015engFundação Oswaldo CruzHanseníaseDiagnósticoForma neural puraLeprosypure neural formDiagnosisHistopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiencyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Nerve biopsy examination is an important auxiliary procedure for diagnosing pure neural leprosy (PNL). When acid-fast bacilli (AFB) are not detected in the nerve sample, the value of other nonspecific histological alterations should be considered along with pertinent clinical, electroneuromyographical and laboratory data (the detection of Mycobacterium leprae DNA with polymerase chain reaction and the detection of serum anti-phenolic glycolipid 1 antibodies) to support a possible or probable PNL diagnosis. Three hundred forty nerve samples [144 from PNL patients and 196 from patients with non-leprosy peripheral neuropathies (NLN)] were examined. Both AFB-negative and AFB-positive PNL samples had more frequent histopathological alterations (epithelioid granulomas, mononuclear infiltrates, fibrosis, perineurial and subperineurial oedema and decreased numbers of myelinated fibres) than the NLN group. Multivariate analysis revealed that independently, mononuclear infiltrate and perineurial fibrosis were more common in the PNL group and were able to correctly classify AFB-negative PNL samples. These results indicate that even in the absence of AFB, these histopathological nerve alterations may justify a PNL diagnosis when observed in conjunction with pertinent clinical, epidemiological and laboratory data.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15540/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALsergio_antunes_etal_IOC_2012.pdfsergio_antunes_etal_IOC_2012.pdfapplication/pdf1562744https://www.arca.fiocruz.br/bitstream/icict/15540/2/sergio_antunes_etal_IOC_2012.pdf2d89751f7c4d3d742a42b41930e54b98MD52TEXTsergio_antunes_etal_IOC_2012.pdf.txtsergio_antunes_etal_IOC_2012.pdf.txtExtracted texttext/plain39673https://www.arca.fiocruz.br/bitstream/icict/15540/3/sergio_antunes_etal_IOC_2012.pdf.txt30072afd29c90377a7563d91d07d3be4MD53icict/155402022-06-24 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| dc.title.pt_BR.fl_str_mv |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| title |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| spellingShingle |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency Antunes, Sérgio Luiz Gomes Hanseníase Diagnóstico Forma neural pura Leprosy pure neural form Diagnosis |
| title_short |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| title_full |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| title_fullStr |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| title_full_unstemmed |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| title_sort |
Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency |
| author |
Antunes, Sérgio Luiz Gomes |
| author_facet |
Antunes, Sérgio Luiz Gomes Chimelli, Leila Jardim, Márcia Rodrigues Vital, Robson Teixeira Nery, José Augusto da Costa Corte-Real, Suzana Hacker, Mariana Andréa Vilas Boas Sarno, Euzenir Nunes |
| author_role |
author |
| author2 |
Chimelli, Leila Jardim, Márcia Rodrigues Vital, Robson Teixeira Nery, José Augusto da Costa Corte-Real, Suzana Hacker, Mariana Andréa Vilas Boas Sarno, Euzenir Nunes |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Antunes, Sérgio Luiz Gomes Chimelli, Leila Jardim, Márcia Rodrigues Vital, Robson Teixeira Nery, José Augusto da Costa Corte-Real, Suzana Hacker, Mariana Andréa Vilas Boas Sarno, Euzenir Nunes |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Diagnóstico Forma neural pura |
| topic |
Hanseníase Diagnóstico Forma neural pura Leprosy pure neural form Diagnosis |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy pure neural form Diagnosis |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
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2016-08-30T15:54:39Z |
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2016-08-30T15:54:39Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ANTUNES, Sérgio Luiz Gomes; et al. Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. Mem Inst Oswaldo Cruz, v.107, n.2, p. 246-253, Mar. 2012. |
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https://www.arca.fiocruz.br/handle/icict/15540 |
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1678-8060 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762012000200015 |
| identifier_str_mv |
ANTUNES, Sérgio Luiz Gomes; et al. Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. Mem Inst Oswaldo Cruz, v.107, n.2, p. 246-253, Mar. 2012. 1678-8060 10.1590/S0074-02762012000200015 |
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Fundação Oswaldo Cruz |
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Fundação Oswaldo Cruz |
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