Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/53973 |
Resumo: | Universidade Federal de Sergipe. Programa de Pós-Graduação em Biotecnologia – Rede Nordeste de Biotecnologia (RENORBIO). São Cristóvão, SE, Brasil. |
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Cruz, Filipe Jonas Federico daSouza, Daniel Ferreira Almeida deAnjos, Samila Fernandes dos SantosBarbosa, Ana Paula FernandesMarques, Juliana Pedrosa de HolandaSantana, Antônio Euzébio GoulartMoreira, Magna Suzana AlexandreJucá, Mario JorgeBarros, Svetlana Maria Wanderley de2022-07-26T12:56:44Z2022-07-26T12:56:44Z2022CRUZ, Filipe Jonas Federico da et al. Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats. Revista Fitos, v. 16, n. 2, p. 169-180, June. 2022.1808-9569https://www.arca.fiocruz.br/handle/icict/5397310.32712/2446-4775.2022.10852446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdeComparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Sergipe. Programa de Pós-Graduação em Biotecnologia – Rede Nordeste de Biotecnologia (RENORBIO). São Cristóvão, SE, Brasil.Hospital de Urgências Governador João Alves Filho. Aracaju, SE, Brasil.Hospital da Mulher. Maceió, AL, Brasil.Universidade Federal de Alagoas. Faculdade de Medicina. Maceió, AL, Brasil.Universidade Federal de Alagoas. Faculdade de Medicina. Maceió, AL, Brasil.Universidade Federal de Alagoas. Faculdade de Medicina. Maceió, AL, Brasil.Universidade Federal de Alagoas. Faculdade de Medicina. Maceió, AL, Brasil.Universidade Federal de Alagoas. Faculdade de Medicina. Maceió, AL, Brasil.Universidade Estadual de Ciências da Saúde de Alagoas. Maceió, AL, Brasil.Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinogenesis induced by 1,2- dimethylhydrazine (1,2-DMH). The extract reduced the frequency of aberrant crypts regarding to the positive control, but there was no significant difference among the positive control animals, those who received the extract and those receiving standard anticancer drug. Thus, the aqueous extract of Sida cordifolia L. 800 mg/kg showed no statistical impact on carcinogenesis in animal models, but showed a significant antiinflammatory effect on the colon mucosa.Colorectal cancerChemopreventionSida cordifolia L.Aberrant crypt1,2-dymethylhydrazineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/53973/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALf_j_f_et_all.pdfapplication/pdf1563290https://www.arca.fiocruz.br/bitstream/icict/53973/2/f_j_f_et_all.pdf36b62e78ad0c24fecd16b434cc758872MD52icict/539732022-12-12 10:58:21.84oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-12T13:58:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| title |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| spellingShingle |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats Cruz, Filipe Jonas Federico da Colorectal cancer Chemoprevention Sida cordifolia L. Aberrant crypt 1,2-dymethylhydrazine |
| title_short |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| title_full |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| title_fullStr |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| title_full_unstemmed |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| title_sort |
Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats |
| author |
Cruz, Filipe Jonas Federico da |
| author_facet |
Cruz, Filipe Jonas Federico da Souza, Daniel Ferreira Almeida de Anjos, Samila Fernandes dos Santos Barbosa, Ana Paula Fernandes Marques, Juliana Pedrosa de Holanda Santana, Antônio Euzébio Goulart Moreira, Magna Suzana Alexandre Jucá, Mario Jorge Barros, Svetlana Maria Wanderley de |
| author_role |
author |
| author2 |
Souza, Daniel Ferreira Almeida de Anjos, Samila Fernandes dos Santos Barbosa, Ana Paula Fernandes Marques, Juliana Pedrosa de Holanda Santana, Antônio Euzébio Goulart Moreira, Magna Suzana Alexandre Jucá, Mario Jorge Barros, Svetlana Maria Wanderley de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cruz, Filipe Jonas Federico da Souza, Daniel Ferreira Almeida de Anjos, Samila Fernandes dos Santos Barbosa, Ana Paula Fernandes Marques, Juliana Pedrosa de Holanda Santana, Antônio Euzébio Goulart Moreira, Magna Suzana Alexandre Jucá, Mario Jorge Barros, Svetlana Maria Wanderley de |
| dc.subject.en.en_US.fl_str_mv |
Colorectal cancer Chemoprevention Sida cordifolia L. Aberrant crypt 1,2-dymethylhydrazine |
| topic |
Colorectal cancer Chemoprevention Sida cordifolia L. Aberrant crypt 1,2-dymethylhydrazine |
| description |
Universidade Federal de Sergipe. Programa de Pós-Graduação em Biotecnologia – Rede Nordeste de Biotecnologia (RENORBIO). São Cristóvão, SE, Brasil. |
| publishDate |
2022 |
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2022-07-26T12:56:44Z |
| dc.date.available.fl_str_mv |
2022-07-26T12:56:44Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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CRUZ, Filipe Jonas Federico da et al. Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats. Revista Fitos, v. 16, n. 2, p. 169-180, June. 2022. |
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https://www.arca.fiocruz.br/handle/icict/53973 |
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1808-9569 |
| dc.identifier.doi.none.fl_str_mv |
10.32712/2446-4775.2022.1085 |
| dc.identifier.eissn.none.fl_str_mv |
2446-4775 |
| identifier_str_mv |
CRUZ, Filipe Jonas Federico da et al. Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats. Revista Fitos, v. 16, n. 2, p. 169-180, June. 2022. 1808-9569 10.32712/2446-4775.2022.1085 2446-4775 |
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Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde |
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Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde |
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